• Vitamin B12 Deficiency

    (Vitamin B12 Deficiency; Macrocytic Achylic Anemia)


    Vitamin B12 helps in red blood cell formation, production of DNA, and function of the nervous system.
    Vitamin B12 deficiency can occur when the body needs more vitamin B12 than it receives from the diet. Alternatively, the condition may occur when the body is unable to use vitamin B12 from the diet. A shortage of vitamin B12 can lead to anemia . Anemia occurs when levels of red blood cells are abnormally low and there is insufficient delivery of oxygen by red blood cells from the lungs to the cells of the body.
    Red Blood Cells
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    There are many causes of vitamin B12 deficiency, such as:
    • Removal of part of the small intestine or stomach
    • Poor absorption of B12 in older adults
    • Long-term use of certain acid-reducing stomach medications:
      • H2 blockers
      • Proton pump inhibitors
      Atrophic gastritis (inflammation of the stomach) due to: Disorders affecting vitamin absorption: Inadequate intake of vitamin B12
      • Long-term veganism or vegetarianism
      • Breastfed infants of vegan or vegetarian mothers
      • Poor nutrition
      • Inadequate nutrition for a pregnant woman
      • Chronic alcohol abuse
    • Chronic intestinal conditions that lead to malabsorption
    • Inflammation of the intestine due to radiation treatment
    • Malnutrition
    • Increased need of vitamin B12: Metabolic disorders:

    Risk Factors

    The following factors increase your chance of developing vitamin B12 deficiency:
    • Alcoholism
    • Use of certain drugs:
      • Biguanides for diabetes
      • Cimetidine
      • Acid-reducing medications
    • Strict vegan or vegetarian diet


    The symptoms of pernicious anemia can vary from person-to-person. Symptoms may change or worsen over time.
    Symptoms can include:
    • Sensation of pins and needles in feet or hands
    • Stinging sensation on the tongue or smooth red tongue
    • Substantial weight loss
    • Tiredness
    • Paleness
    • Altered sense of taste
    • Confusion
    • Depression
    • Impaired sense of balance, especially in the dark
    • Inability to sense vibrations in feet or legs
    • Lightheadedness when changing to standing position
    • Rapid heart rate


    You will be asked about your symptoms and medical history. A physical exam will be done. Tests may include the following:
    • Complete blood count (CBC)—a count of the number of red and white blood cells in a blood sample
    • Vitamin B12 level—a test that measures the amount of vitamin B12 in the blood
    • Methylmalonic acid (MMA) level
    • Homocysteine level
    • Schilling test—a test in which a small amount of radiation is used to assess the absorption of vitamin B12 deficiency
    • Folate level—a measurement of the amount of a B vitamin called folic acid
    • Intrinsic factor antibodies—this test helps to determine pernicious anemia as the cause of symptoms


    Talk with your doctor about the best treatment plan for you. Treatment options include the following:

    Oral Vitamin B12 Supplement

    This treatment consists of high doses of an oral vitamin B12 supplement.

    Vitamin B12 Injections

    The doctor may advise injections of vitamin B12 into a muscle. Injections of vitamin B12 may be given frequently at first. When blood tests show improvement, the injections may be given on a monthly basis.

    Treatment with Antibiotics

    This type of medication may be needed in cases where bacterial overgrowth in the intestines exists. The bacteria compete with the body to absorb the vitamin B12 in the intestines.

    Intranasal Vitamin B12

    The doctor may advise a supplement of vitamin B12 that is placed in the nose.


    To help reduce your chances of developing a deficiency of vitamin B12, take the following steps:
      Eat foods that are a source of vitamin B12, such as:
      • Eggs, milk, cheese, and milk products
      • Meat, fish, shellfish, and poultry
      • Soy-based meat substitutes
      • Some soy and rice beverages
    • Avoid long-term over-consumption of alcohol.
    • As directed by your doctor, take a daily supplement containing vitamin B12.
    • As directed by your doctor, give vitamin B12 to your breastfed baby if you are a vegan or vegetarian.
    • Undergo testing if your doctor suspects you have a bacterial infection.
    • Have your doctor monitor your health closely if you are taking certain medications:
      • Biguanides
      • Cimetidine
      • Acid-reducing medications


    Family Doctor—American Academy of Family Physicians http://familydoctor.org

    National Institutes of Health Office of Dietary Supplements http://ods.od.nih.gov


    College of Family Physicians of Canada http://www.cfpc.ca

    Health Canada https://www.canada.ca


    Food sources of vitamin B12. Dietitians of Canada website. Available at: https://www.dietitians.ca/Your-Health/Nutrition-A-Z/Vitamins/Food-Sources-of-Vitamin-B12.aspx. Accessed November 7, 2017.

    Pernicious anemia. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116294/Pernicious-anemia. Updated May 17, 2017. Accessed November 7, 2017.

    Vitamin B12. American Association of Clinical Chemistry—Lab Tests Online website. Available at: http://www.labtestsonline.org/understanding/analytes/vitamin%5Fb12/glance.html. Updated April 24, 2015. Accessed November 7, 2017.

    Vitamin B12. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T233168/Vitamin-B12. Updated November 6, 2017. Accessed November 7, 2017.

    Vitamin B12 deficiency. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116899. Updated December 4, 2015. Accessed November 7, 2017.

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