van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA.
Brassica vegetables and cancer prevention. Epidemiology and mechanisms.
Adv Exp Med Biol
Singh SV, Srivastava SK, Choi S, et al. Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.
J Biol Chem
. 2005;280:19911–24. Epub 2005 Mar 11.
Joseph MA, Moysich KB, Freudenheim JL, et al. Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk.
Johnston N. Sulforaphane halts breast cancer cell growth.
Drug Discov Today
Pham NA, Jacobberger JW, Schimmer AD, et al. The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
Mol Cancer Ther
Tseng E, Scott-Ramsay EA, Morris ME. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.
Exp Biol Med (Maywood)
Myzak MC, Karplus PA, Chung FL, et al. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.
Fahey JW, Haristoy X, Dolan PM, et al. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of
and prevents benzo[a]pyrene-induced stomach tumors.
Proc Natl Acad Sci USA
Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism.
Verhoeven DT, Goldbohm RA, van Poppel G, et al. A review of mechanisms underlying anticarcinogenicity by brassica vegetables.
Chem Biol Interact
Talalay P, Zhang Y. Chemoprotection against cancer by isothiocyanates and glucosinolates.
Biochem Soc Trans
Nestle M. Broccoli sprouts in cancer prevention.
Nestle M. Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: clinical, dietary, and policy implications.
Proc Natl Acad Sci.
Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
Food Chem Toxicol
Gamet-Payrastre L, Li P, Lumeau S, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.
Solowiej E, Kasprzycka-Guttman T, Fiedor P, Rowinski W. Chemoprevention of cancerogenesis—the role of sulforaphane.
Acta Pol Pharm
Frydoonfar HR, McGrath DR, Spigelman AD. The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line.
ANZ J Surg
Chiao JW, Chung FL, Kancherla R, Ahmed T, Mittelman A, Conaway CC. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.
Int J Oncol
Levi MS, Borne RF, Williamson JS. A review of cancer chemopreventive agents [review].
Curr Med Chem
Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.
Cancer Epidemiol Biomarkers Prev
Conaway CC, Getahun SM, Liebes LL, et al. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli.
. 2000;38:168–78. Erratum in:
Steinkellner H, Rabot S, Freywald C, et al. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.
Kelloff GJ, Crowell JA, Steele VE, et al. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents.
. 2000;130(2S Suppl):467S–471S.
Kunz R, Oxman AD. The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials.
Kramer MS. Randomized trials and public health interventions: time to end the scientific double standard.
Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity.
27Tortorella SM, Royce SG, Licciardi PV, Karagiannis TC. Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition. Antioxid Redox Signal. 2015;22(16):1382-1424.
28Lee YJ, Lee SH. Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells.
Mol Med Rep. 2017 June 15 [Epub ahead of print].
29Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P. Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell Longev. 2013 Jul 25 [Epub head of print].
30Kim JK, Park SU. Current potential health benefits of sulforaphane. EXCLI J. 2016;15:571-577.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Copyright © 2012 EBSCO Publishing
All rights reserved.
It's time to stop guessing. If you want to make some changes but just aren't sure how, the free personal health survey from LiveWell is a great place to start.
Fight heart disease and prevent heart attacks. HeartSHAPE® is a painless, non-invasive test that checks pictures of your heart for early-stage coronary disease.
How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.
Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.
This tool considers your height and weight to assess your weight status.
Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.
You clicked on a link that will cause you to leave myWellmont.
For security purposes you will be signed out.