• Urethral Syndrome

    (Urethral Irritation)


    Urethral syndrome is a set of symptoms from inflammation or irritation of the urethra that are not related to a bacterial or viral infection. The urethra is the tube that carries urine out of the body from the bladder.
    Female Urethra
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    Because there is no evidence of infection, the cause of urethral syndrome is often difficult to determine. Possible causes include:
    • Undetected bacterial or viral infection of the urethra
    • Irritation of the urethra, caused by:
      • Radiation therapy or exposure
      • Chemotherapy
      • Spermicidal jellies used during sex
      • Bubble baths
      • Irritating soaps
      • Scents or perfumes
      • Injury to the urethra caused by a blow to the pelvic area
      • Sexual intercourse (especially in women)
      • Urinary irritants, such as caffeine and certain foods
      In women, irritation of the urethra may be caused by:
      • Feminine hygiene sprays or douches
      • Sanitary napkins
      • Contraceptive gels
      • Condoms

    Risk Factors

    Urethral syndrome is most common in women. Factors that may lead to an undetected infection:
    • Unprotected sex (without use of a condom)
    • History of sexually transmitted diseases
    • Bacterial infection of other parts of the urinary tract, such as the bladder or kidney
    • Medications that reduce your ability to fight infections
    • Structural problems, such as narrowing of the urethra


    Urethral syndrome may cause:
    • Pain and/or burning while urinating
    • Difficulty urinating (especially after intercourse)
    • Increase in urinary:
      • Frequency
      • Urgency
      • Blood in the urine
    • Swelling and/or tenderness in the groin
    • Pain during intercourse
    In men, urethral syndrome may specifically cause:
    • Discharge from the penis
    • Blood in semen
    • Pain during ejaculation
    • Swollen and/or tender testicles


    You will be asked about your symptoms and medical history. A physical exam will be done. It will include a pelvic exam. Urethral syndrome is usually diagnosed when symptoms of urethritis are present without evidence of an infection.
    Tests may include:
    • Urine tests or urethral swab tests for lab study
    • Tests for sexually transmitted diseases
    • Cystoscopy and/or urethroscopy
    • Pelvic ultrasound


    Treatment may include:


    • Antibiotics for a possible undetected infection
    • Anesthetics
    • Antispasmodics to reduce bladder spasms
    • Antidepressants
    • Alpha-blocking drugs to relax muscle tone

    Avoidance of Irritants

    Avoid irritants that may cause urethral syndrome. Then, wait and see if your condition improves.


    Surgery may be done in cases where narrowing of the urethra is thought to be causing the urethral syndrome.


    To reduce your chance of urethral syndrome:
      Avoid the use of:
      • Spermicidal jellies
      • Bubble baths
      • Irritating soaps
      • Scents or perfumes
      • Feminine hygiene sprays and douches
      • Urinary irritant foods and beverages
    • Practice safe sex, including using condoms.
    • Urinate immediately after sexual intercourse.
    • Make sure sexually transmitted diseases are treated quickly and completely for you and your partner(s).
    • Drink plenty of fluids.


    Centers for Disease Control and Prevention https://www.cdc.gov

    National Institute of Diabetes and Digestive and Kidney Diseases https://www.niddk.nih.gov


    HealthLink BC https://www.healthlinkbc.ca

    The Kidney Foundation of Canada https://www.kidney.ca


    Costantine E, Zucchi A, et al. Treatment of urethral syndrome: a prospective randomized study with Nd: YAG laser. Urol Int. 2006;76:134-138.

    Gittes RF, Nakamura RM. Female urethral syndrome. A female prostatitis? West J Med. 1996;164(5):435-438.

    Nongonococcal urethritis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116488/Nongonococcal-urethritis. Updated May 31, 2017. Accessed September 7, 2017.

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