11530 Health Library | Health and Wellness | Wellmont Health System
  • Stroke

    (Cerebrovascular Accident; CVA; Cerebral Infarct; Brain Attack)

    Definition

    Stroke is a brain injury. It occurs when the blood supply to the brain is interrupted. Without oxygen and nutrients from blood, brain tissue dies in less than 10 minutes. The tissue death causes a sudden loss in function.

    Causes

    A stroke occurs when there is a loss of blood flow. It may happen because of a blockage in blood flow, called ischemic stroke, or because of bleeding in the brain, called hemorrhagic stroke.
    A sudden decrease in the flow of blood may be caused by:
      A clot that breaks off from another part of the body (such as the heart or neck) and lodges in blood vessel of neck or brain—there are certain conditions which predispose people to form blood clots, such as:
    • A blood clot that forms in neck or brain
    • Atherosclerosis —a build-up of fatty substances along the inner lining of the artery that gradually decrease the area the blood can flow through
    • Inflammatory conditions in the blood vessels (vasculitis)
    Hemorrhagic stroke occur when blood vessels break and bleed into or around the brain. This can happen after an injury.
    Hemorrhagic vs. Ischemic Stroke
    factsheet image
    Copyright © Nucleus Medical Media, Inc.

    Risk Factors

    The following factors can increase your risk of stroke but the risk can be modified with lifestyle changes and proper medical care:
    Other factors that can increase your risk of stroke but can not be modified include:
    • Prior stroke or pre-existing cardiovascular disease, such as heart attack
    • Prior transient ischemic attack (TIA) —some people have this a "warning stroke" with symptoms that resolve in short period of time
    • Age: 60 or older
    • Family members who have had a stroke
    • Gender: males are at greater risk
    • Race: Black, Asian, Hispanic
    • Blood disorders which increase clotting in sickle cell disease and polycythemia
    • Valvular heart disease, such as mitral stenosis

    Symptoms

    Symptoms occur suddenly. They differ depending on the part of the brain affected. Also, multiple symptoms can happen at the same time. If you notice any of the symptoms below, call emergency help right away. Getting help immediately is important, because brain tissue dies quickly when deprived of oxygen.
    • Sudden weakness or numbness of face, arm, or leg, especially on one side of the body
    • Sudden confusion
    • Sudden trouble speaking or understanding
    • Sudden trouble seeing in one or both eyes
    • Sudden dizziness, trouble walking, loss of balance, or coordination
    • Sudden severe headache with no known cause

    Diagnosis

    Having a stroke is an emergency. Tests may include:
    • Neurological exams
    • Electrocardiogram (ECG, EKG) —a test that records the heart's activity by measuring electrical currents through the heart muscle
    • Brain and blood vessel imaging by:
      • Computed tomography (CT) scan —a type of x-ray that uses a computer to make pictures of the brain, helps doctors identify hemorrhagic versus ischemic stroke
      • Magnetic resonance imaging (MRI) scan —a test that uses magnetic waves to make pictures of the brain
      • Ultrasonography—a test that uses sound waves to examine the blood vessels feeding the brain
    • Blood tests, including cholesterol, homocysteine, prothrombin time , and other coagulation tests
    Other tests may include:
    • Arteriography (angiography)—a catheter is placed in a blood vessel in the groin and threaded up to the brain, shows arteries in the brain
    • Magnetic resonance angiography (MRA) —shows brain blood vessels by mapping blood flow
    • CT angiogram (CTA)—this test uses a CT scanner, gives images of the blood vessels inside the brain after a dye is injected into the veins
    • Functional MRI—shows brain activity by picking up signals from oxygenated blood
    • Doppler ultrasound —shows narrowing of the arteries (carotid and vertebral) supplying the brain, evaluates flow of blood in brain
    • Echocardiography —a test that uses high-frequency sound waves (ultrasound) to examine the size, shape, and motion of the heart, shows if the clot comes from one of the heart's chambers

    Treatment

    Immediate treatment is needed to :
    • Dissolve a clot causing an ischemic stroke
    • Stop the bleeding during a hemorrhagic stroke
    Treatment after immediate care will aim to:
    • Reduce the chance of later strokes
    • Improve functioning
    • Overcome disabilities
    Supportive care may also include:

    Medications

    Medications may include:
      Clot-dissolving drugs—if a clot is causing the problem
      • Given shortly after the start of symptoms—typically given within 4½ hours by IV, or intra-arterially (IA) within six hours
      • Used in carefully selected patients
      Antiplatelet drugs—decreases the body's ability to make clots
      • Aspirin
      • Clopidogrel (Plavix) and dipyridamole/aspirin (Aggrenox)
      Blood-thinning drugs (anticoagulants)
      • Heparin , given by vein
      • Oral medicine (eg, warfarin ), given if long-term treatment with blood-thinner is expected
      • Lovenox or other related medicines, given subcutaneously (under skin)
    Other drugs may be given to help:
    • Control blood pressure ( labetalol , the first-line drug, or sodium nitroprusside)—although blood pressure is allowed to run high initially (called permissive hypertension)
    • Reduce chance of additional clot formation (aspirin or similar medicines)
    • Reduce brain swelling
    • Correct irregular heart rhythm (eg, atrial fibrillation )

    Surgery

    A surgery may be done to prevent damage or allow blood flow back into the affected area. Surgical options after a stroke include:
    • Extracranial/intracranial bypass—blood supply is rerouted around a blocked artery using a healthy scalp artery
    • Craniotomy—done to relieve pressure build-up in the brain caused by swelling
    • Embolectomy—a catheter is threaded through blood vessels to the clot; a special device will either mechanically remove the clot or deliver clot-dissolving medicine directly to the area
    Other surgeries may be performed following a stroke or TIA to prevent a recurrence. These surgical options include:
    • Carotid endarterectomy (CEA) —fatty deposits are removed from a carotid artery (major arteries in the neck that lead to the brain)
    • Carotid angioplasty and stenting —less invasive procedure, carotid artery is widened and a mesh tube is placed into the artery to keep it open
    Even though endarterectomy is more invasive, it may be preferred over angioplasty for some patients. Angioplasty may be an option for patients who are have a high risk of complications from CEA.

    Rehabilitation

    Rehabilitation can be an important part of your recovery. Rehabilitation may include:
    • Physical therapy—to regain as much movement as possible
    • Occupational therapy—to assist in everyday tasks and self care
    • Speech therapy—to improve swallowing and speech challenges
    • Psychological therapy—to improve mood and decrease depression

    Prevention

    Lifestyle changes that can help reduce your chance of getting a stroke include:
    • Exercise regularly.
    • Eat more fruits, vegetables , and whole grains . Limit dietary salt and fat .
    • Stop smoking .
    • Increase your consumption of fish.
    • Drink alcohol only in moderation (1-2 drinks per day).
    • Maintain a healthy weight.
    • Check blood pressure frequently . Follow your doctor's recommendations for keeping it in a safe range.
    • Take a low dose of aspirin (50-325 milligrams per day) if your doctor says it is safe.
    • Keep chronic medical conditions under control. This includes high cholesterol and diabetes.
    • Talk to your doctor about the use of a statins. These types of drugs may help prevent certain kinds of strokes in some people.
    • Seek medical care if you have symptoms of a stroke, even if symptoms stop.
    • Stop the use of recreational drugs (eg, cocaine, heroin, marijuana, amphetamines).

    RESOURCES

    American Heart Association http://www.heart.org/HEARTORG/

    National Stroke Association http://www.stroke.org/

    CANADIAN RESOURCES

    Heart and Stroke Foundation of Canada http://ww2.heartandstroke.ca/

    Public Health Agency of Canada http://www.publichealth.gc.ca/

    References

    Adams H, Adams R, Del Zoppo G, Goldstein LB. Guidelines for the early management of patients with ischemic stroke: 2005 guidelines update: a scientific statement from the Stroke Council of the American Heart Association/American Stroke Association. Stroke . 2005;36:916-923.

    Carpenter C, Keim S, Milne W, Meurer W, Barsan W. Thrombolytic therapy for acute ischemic stroke beyond three hours. J Emerg Med . 2010; June 23rd [Epub ahead of print].

    Duncan PW, Zorowitz R, Bates B, et al. Stroke Council of the American Heart Association/American Stroke Association. Management of adult stroke rehabilitation care: a clinical practice guideline. Stroke . 2005;36:100-143.

    FDA approves Pradaxa to prevent stroke in people with atrial fibrillation. United States Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm230241.htm . Published October 19, 2010. Accessed September 4, 2012.

    Furie KL, Kasner SE, Adams RJ, et al. Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke . 2010 October 21. Available at: http://stroke.ahajournals.org/cgi/reprint/STR.0b013e3181f7d043v1 . Updated October 21, 2010. Accessed September 4, 2012.

    Grau AJ, Barth C, Geletneky B, et al. Association between recent sports activity, sports activity in young adulthood, and stroke. Stroke . 2009;40:426-431. Epub 2008 Dec 24.

    He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, Goldbourt U, Greenland P. Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke . 2004; 35(7):1538-1542.

    Know stroke. Stroke National Institute of Neurological Disorders and Stroke website. Available at: http://stroke.nih.gov . Accessed September 4, 2012.

    Rowland LP, Merritt HH. Merritt's Neurology . 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005.

    Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the AHA/ASA Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention. Stroke . 2006;37:577-617.

    Signs and symptoms. National Stroke Association website. Available at: http://www.stroke.org/site/PageServer?pagename=SYMP . A Accessed September 4, 2012.

    Stroke (acute management). EBSCO Publishing DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated August 30, 2012. Accessed September 4, 2012.

    Warning signs. National Stroke Association website. Available at: http://www.strokeassociation.org/STROKEORG/WarningSigns/Stroke-Warning-Signs%5FUCM%5F308528%5FSubHomePage.jsp . Accessed September 4, 2012.

    11/20/06 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Mas JL, Chatellier G, Beyssen B, et al. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med . 2006;355:1726-1729.

    12/16/2008 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Farquhar C, Marjoribanks J, Lethaby A, Suckling J, Lamberts Q. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev . 2008;CD004143.

    10/9/2009 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Mitchell PH, Veith RC, Becker KJ, et al. Brief psychosocial-behavioral intervention with antidepressant reduces poststroke depression significantly more than usual care with antidepressant: living well with stroke: randomized, controlled trial. Stroke . 2009;40:3073-3078.

    3/28/2011 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Park Y, Subar AF, Hollenbeck A, Schatzkin A. Dietary Fiber Intake and Mortality in the NIH-AARP Diet and Health Study. Arch Intern Med . 2011 Feb 14. [Epub ahead of print]

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