• Plague

    (Pneumonic Plague; Bubonic Plague; Septicemic Plague; Pharyngeal Plague)


    Plague is an infectious disease with an infamous past in human history. Because of its contagious nature, plague is a weapon of bioterrorism. Although it is not as common as it once was, outbreaks of plague do occur today.
    Types of plague include:
    • Pneumonic—in the lungs, from breathing in droplets or as a progression of another type
    • Bubonic—in the lymph nodes, occurring after a flea bite
    • Septicemic—a body system-wide infection, occurring after a flea bite
    Plague is treated with isolation and antibiotics.


    Plague is caused by specific bacteria.
    Bubonic and septicemic plagues are spread by bites from infected fleas. Transmission can also occur when a person comes in contact with infected tissue or bodily fluids from another person or animal.
    Pneumonic plague is spread by droplets in the air when an infected person coughs or sneezes. The disease is transmitted to another person when the droplets are inhaled. Transmission by droplets is the only way pneumonic plague spreads among people.
    Pneumonic Plague Transmission
    Droplets from an infected person are inhaled into the lungs.
    Copyright © Nucleus Medical Media, Inc.

    Risk Factors

    Factors that may increase your chance of plague include:
    • Exposure to the bacteria
    • Contact with fleas or infected rodents
    • Living in the southwestern United States


    Pneumonic plague may cause:
    • Fever
    • Weakness
    • Headache
    • Cough
    • Bloody or watery mucous
    • Difficulty breathing
    • Chest pain
    Bubonic plague may cause:
    • Fever
    • Chills
    • Weakness
    • Headache
    • Swollen, tender lymph nodes
    • Skin that may appear red and tight over affected lymph nodes
    Septicemic plague may cause:
    • Bleeding under the skin
    • Black fingers, toes, or nose
    • Fever
    • Chills
    • Weakness
    Complications of plague include shock , organ failure, and death.


    You will be asked about your symptoms and medical history. A physical exam will be done. Your doctor may ask about the possible source of exposure.
    Your bodily fluids will be tested. This can be done with:
    • Blood tests
    • Cultures of body fluids
    Images may be taken of your lungs. This can be done with a chest x-ray.


    Starting antibiotics early is important. Any delay increases the risk of death. The drugs are injected in a muscle or given through a vein. Later in treatment, some drugs can be given by mouth. A person with lung symptoms will be placed in isolation to protect others. Caregivers and visitors should wear a mask, gloves, goggles, and a gown. Cases are reported to public health officials.

    Supportive Care for Septicemic Plague

    Health professionals will monitor those with septicemic plague for changes in status and take appropriate action. Maintaining adequate heart function, blood pressure, and oxygen supply are important.


    Antibiotics may prevent infection following close contact with someone who has the disease. The drugs should be taken daily while in contact, and for 7 days after the last exposure. In addition, the caregiver and person with plague should wear masks.
    In the event of a terrorism exposure, antibiotics may be given to people in the affected areas who have a fever or cough. A vaccine does not exist for pneumonic plague.
    Measures to prevent naturally occurring plague include:
    • Reduce or control the rodent population near your home, since rodents carry fleas.
    • Wear gloves when handling or skinning animals to protect contact with your skin.
    • Use insect repellent containing DEET when you are outside.
    • Keep fleas off your pets by using flea control products.
    • Keep dogs and cats from sleeping in your bed if they roam in endemic areas.


    Centers for Disease Control and Prevention http://www.cdc.gov

    CEPAR—Johns Hopkins Office of Critical Event Preparedness and Response http://www.hopkins-cepar.org


    Health Canada http://www.hc-sc.gc.ca

    Public Health Agency of Canada http://www.phac-aspc.gc.ca


    Inglesby TV, Dennis DT, Henderson DA, et al. Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA. 2000;283(17):2281-2290.

    Plague. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/plague. Updated March 3, 2015. Accessed June 10, 2015.

    Plague. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116252/Plague. Updated September 8, 2015. Accessed September 14, 2016.

    Revision Information

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