• Paget's Disease

    (Osteitis Deformans)


    Paget's disease results in enlarged and deformed bones. It is a chronic (long-term) condition. Any bone in the body can be affected. However, the most common sites are the spine, skull, pelvis, thighs, and lower legs. The disease does not usually spread to other normal bones.
    Normal Bone Structure
    Bone Matrix
    Copyright © Nucleus Medical Media, Inc.


    Paget's disease is caused by a malfunction in bone formation. Normally, bones are constantly being broken down by cells called osteoclasts. They are then rebuilt by cells called osteoblasts. With Paget's disease, bones are broken down abnormally fast, and new bone replacement is loose and bulky, instead of strong and compact. These poorly formed bones may become weak. They also may bend over time.
    The exact cause of this bone malformation is unknown. It is associated with family history. Some experts believe that Paget's disease may be triggered early in life by a viral infection.

    Risk Factors

    A risk factor is something that increases your chance of getting a disease or condition. Risk factors for Paget's disease include:
    • Family history of Paget's disease, especially in a parent, sibling, or child
    • Race: Anglo-Saxon, European
    • Age: 40 or older
    • In United States, residence in northern states


    In the early stages, most people have no noticeable symptoms. In later stages, symptoms may include:
    • Swelling or deformity of a limb
    • Increased head size
    • Bowing of a limb
    • Curvature of the spine
    • Chronic bone pain, especially legs, hips, or spine
    • Frequent fractures
    • Problems with walking or gait
    • Headaches, facial pain, or hearing loss (when the skull bones are affected)
    • Swollen or painful joints due to damaged joint cartilage
    • Numbness, tingling, pain, or weakness from pressure on nerves
    Depending on the bone site, Paget's disease may result in:


    Your doctor will ask about your symptoms and medical history. He or she will do a physical exam. Tests may include:
    • Blood tests—such as those for alkaline phosphatase or calcium
    • X-ray—a test that uses radiation to take a picture of the bones
    • Bone scan—a series of pictures of bones taken after injection of a small amount of radioactive material


    It is best to begin treatment as soon as possible. Treatment options include:


    Medications may include:
    • Pain medicine—such as acetaminophen (Tylenol) or nonsteroidal anti-inflammatory drugs
    • Bisphosphonates—usually by tablet or by injection
    • Calcitonin—administered by injection or nasal spray


    Surgery may be required if you have one of the following conditions:
    • Bone fracture
    • Severe degenerative arthritis
    • Bone deformity


    Recommendations include:
    • Calcium, usually about 1,000-1,500 mg per day
    • Adequate exposure to sunshine to promote vitamin D production in the skin (but, limit time in the sun to prevent sun burning, wrinkling, and aging)
    • Intake of adequate vitamin D, usually about 400 mg per day (older people may need more)
    • Regular exercise to maintain skeletal health, joint mobility, and normal body weight
    • Avoidance of excess mechanical stress on involved bones
    • A splint for an area at high risk for fracture


    There is no known way to prevent the onset of Paget's disease. People with primary family members who have Paget's disease are encouraged to have a routine alkaline phosphatase blood test every 2-3 years after age 40.


    NIH Osteoporosis and Related Bone Diseases National Resource Center http://www.niams.nih.gov/Health%5FInfo/Bone

    The Paget Foundation http://www.paget.org


    The Arthritis Society http://www.arthritis.ca

    Osteoporosis Canada http://www.osteoporosis.ca


    Albagha OM, Genetic Determinants of Paget's Disease (GDPD) Consortium. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. Nat Genet. 2011;43(7):685-689.

    Michou L, Brown JP. Emerging strategies and therapies for treatment of Paget's disease of bone. Drug Des Devel Ther. 2011;5:225-239.

    National Institutes of Health Osteoporosis and Related Bone Diseases, National Resource Center website. Available at: http://www.niams.nih.gov/Health%5FInfo/Bone. Accessed October 11, 2005.

    Questions and answers about Paget's disease of bone. The Paget Foundation website. Available at: http://www.niams.nih.gov/Health%5FInfo/Bone. Published 2008. Accessed July 24, 2009.

    Schneider D, Hofmann MT, et al. Diagnosis and treatment of paget's disease of bone. Am Fam Physician. 2002;15;65(10).

    Revision Information

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