• Morton Neuroma

    (Interdigital Neuroma; Intermetatarsal Neuroma)


    Morton neuroma is painful thickening of the tissue around one of the nerves in the foot. It can affect any of the toes in the foot. However, it most often affects the nerves that run between the third and fourth, or second and third toes.
    Nerves of the Foot
    Foot Anatomy Nerve and muscle
    Copyright © Nucleus Medical Media, Inc.


    The thickening of the nerve caused by inflammation and the build up of fibrous tissue on the nerve's outer coating. This fibrous build-up is a reaction to the irritation resulting from nearby bones and ligaments rubbing against the nerves.
    Irritation can be caused by:
    • Wearing shoes that are too tight
    • Wearing shoes that place the foot in an awkward position, such as with high heels
    • A foot that is mechanically unstable
    • Repetitive trauma to the foot such as from sports activities like tennis, basketball, and running
    • Trauma to the foot caused by an injury such as a sprain or fracture
    It is unusual for more than one Morton neuroma to occur on one foot at the same time. It is rare for Morton neuroma to occur on both feet at the same time.

    Risk Factors

    Morton neuroma is more common in women. Other factors that may increase your chance of Morton neuroma include:
    • Wearing narrow and/or high-heeled shoes
    • Obesity
    • Injuries to the foot
    • Activities that cause repetitive trauma to the foot such as sports-related activities


    Morton neuroma may cause:
    • Burning, pain, tingling, and numbness often shooting into the toes
    • Discomfort that is worse while walking
    • Feeling of a lump between the toes
    • Symptoms are usually temporarily relieved when:
      • Taking off the shoes
      • Flexing the toes
      • Rubbing the feet


    The doctor will ask about your symptoms and medical history. A physical exam will be done. Initial diagnosis of Morton neuroma is based on your description of the type and location of pain and discomfort in the foot. The diagnosis will be confirmed by:
      Physical exam of the foot, including:
      • Checking for mechanical abnormalities in the foot
      • Squeezing the side of the foot, which will usually cause pain when Morton neuroma is present
      Examination of your shoes to:
      • Check for excess wear in parts of the shoe
      • Check to see whether the shoes are too tight
    Imaging tests evaluate the foot and surrounding structures. This may be done with:
    Injections of local anesthetic can also be used for diagnosis


    Treatments may include:

    Rehabilitation Measures to Reduce Nerve Irritation

    • Switching to low-heeled, wide-toed shoes with good arch support
    • Wearing padding in the shoes and/or between the toes
    • Wearing shoe inserts to correct a mechanical abnormality of the foot
    • Having ultrasound, electrical stimulation, whirlpool, and massage done on the foot

    Injection of Medication

    The foot may be injected with corticosteroids mixed with a local anesthetic in order to reduce pain. Relief may be only temporary however, if the mechanical irritation is not corrected. Injections with other types of medications such as alcohol, phenol, or vitamin B12 are sometimes used.


    Surgery to remove the neuroma may be recommended if more conservative treatment does not solve the problem. While surgery usually relieves or completely removes the symptoms, it often leaves a permanent numb feeling at the site of the neuroma.


    To help reduce your chance of Morton neuroma:
    • Avoid wearing tight and/or high-heeled shoes.
    • Maintain or achieve ideal body weight.
    • If you play sports, wear roomy, properly fitting athletic footwear.


    American Podiatric Medical Association http://www.apma.org

    National Institute of Arthritis and Musculoskeletal and Skin Diseases https://www.niams.nih.gov


    Canadian Orthopaedic Association http://coa-aco.org

    When it Hurts to Move—Canadian Orthopaedic Foundation http://whenithurtstomove.org


    Clinical Practice Guideline Forefoot Disorders Panel, Thomas JL, Blitch EL 4th, Chaney DM, et al. Diagnosis and treatment of forefoot disorders. Section 3. Morton's intermetatarsal neuroma. J Foot Ankle Surg. 2009;48(2):251-256.

    Morton neuroma. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114041/Morton-neuroma. Updated June 8, 2016. Accessed September 5, 2017.

    Morton's neuroma (intermetatatarsal neuroma). Foot Health Facts—American College of Foot and Ankle Surgeons website. Available at: http://www.foothealthfacts.org/footankleinfo/mortons-neuroma.htm?terms=morton%27s%20neuroma. Accessed September 5, 2017.

    Thomson CE, Gibson JN, Martin D. Interventions for the treatment of Morton's neuroma. Cochrane Database of Sys Rev. 2004;(3):CD003118.

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