• Cluster Headache


    Cluster headache is a type of severe, recurring pain that is located on one side of the head. It received its name from the clustering, or pattern, of frequent headaches that usually occur.
    There are 2 main types of cluster headaches:
    • Episodic—These occur one or more times daily for multiple weeks. The headaches then go away and come back months or years later.
    • Chronic—These occur almost daily with headache-free periods lasting less than a month.
    Either type of headache may switch to the other type.


    The cause of cluster headaches is not known. It is thought that there is abnormal activation of the area of the brain that is responsible for regulating temperature, blood pressure, hormone release, and sleep. The pain is thought to be caused by a combination of widening of the blood vessels and inflammation of the nerves of the face.
    Other possible causes include:

    Risk Factors

    Men aged 20-50 years are more likely to get cluster headaches. Other factors that may increase your chance of cluster headaches include:
    • Prior head surgery or head injury
    • Family history of cluster headaches


    Cluster headaches may cause:
      Stabbing, penetrating, burning, or explosive head pain that:
      • Begins suddenly
      • Is on one side of the head, but not both
      • Often starts around the eye and spreads to the same side of the head
      • Causes facial flushing
      • Can occur daily or almost every day for multiple weeks
      • Can occur 1-8 times per day
      • Lasts 15 minutes to 3 hours
      • Often occurs at about the same time each day
      • May increase in intensity over time
      • May start within 2 hours of going to sleep
      • Can awaken you from sleep
      • Causes an aura—This can include visual disturbance, visual spots, or the inability to move one side of the body.
    • Restlessness and agitation
    • Nausea
    During the headache, other symptoms may occur on the affected side, including:
    • Stuffy or runny nose
    • Redness or watering of the eye on one side
    • Droopy eyelid
    • Constriction of the pupil of the eye
    • Facial swelling and flushing, sweating
    • Sensitivity to light and noise
    Symptoms of a Cluster Headache
    Copyright © Nucleus Medical Media, Inc.


    The doctor will ask about your symptoms and medical history. A physical and neurological exam will be done. A neurological exam may include examining:
    • Mental status
    • Cranial nerve functioning
    • Motor and sensory functioning
    • Reflexes
    • Coordination
    • Walking
    The doctor will ask about the frequency and pattern of your headaches. To help provide answers, you may consider keeping a diary of:
    • When your headaches started and ended
    • What you were doing at the time
    • What you tried to relieve the pain
    Imaging tests to evaluate the brain include:


    Treatment aims to reduce the frequency of headaches and relieving pain.

    Lifestyle Changes and Self-care

    • Maintain the same sleep routine. Avoid afternoon naps or sleeping in, which may bring on more headaches.
    • Do not drink alcoholic beverages. Even a small amount of alcohol can trigger a headache during a cluster period.
    • Learn stress management techniques. Stress can bring on a headache.
    • Do not smoke. Tobacco may interfere with medications.
    • Find out what your headache triggers are and take steps to avoid them.


    Medications used to treat migraines often relieve sudden attacks of cluster headaches. These drugs must be taken at the first sign of a headache. Other medications may also be prescribed.
    In some cases, the headache does not last long enough for medications to be helpful. Sometimes, the medications just delay an attack, rather than stop an attack.
    Painkillers, especially opioids, may not be effective during an acute attack.
    Other medications may be given to prevent or reduce the frequency of headaches.

    Oxygen Therapy

    Breathing 100% oxygen for 10-15 minutes often relieves cluster headache pain. This is often viewed as the first-line therapy for cluster headache. The oxygen appears to decrease blood flow to the affected area of the brain. People under age 50 who have episodic cluster headaches seem to benefit most from oxygen therapy.
    Oxygen therapy can be expensive. There are also risks with this therapy.


    As a last resort, some doctors may recommend cutting or destroying a facial nerve to eliminate pain.


    To help reduce your chance of cluster headaches:


    American Headache Society http://www.achenet.org

    National Headache Foundation http://www.headaches.org


    Health Canada https://www.canada.ca

    Help for Headaches http://www.headache-help.org


    Beck E, Sieber WJ, Trejo R. Management of cluster headache. Am Fam Physician. 2005;71(4):717-724.

    Cittadini E, May A, Straube A, et al. Effectiveness of intranasal zolmitriptan in acute cluster headache. Arch Neurol. 2006;63(11):1537-1542.

    Cluster headache. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116292/Cluster-headache. Updated February 16, 2016. Accessed November 10, 2017.

    Finocchi C, Del Sette M, Angeli S, Rizzi D, Gandolfo C. Cluster headache and right-to-left shunt on contrast transcranial Doppler: a case-control study. Neurology. 2004;63(7):1309-1310.

    Leone M, Bussone G. Pathophysiology of autonomic trigeminal neuralgias. Lancet Neurol. 2009;8(8):755-764.

    Leroux E, Valade D, Taifas I, et al. Suboccipital steroid injections for transitional treatment of patients with more than two cluster headache attacks per day: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2011;10(10):891-897.

    May A, Leone M, Afra J, et al. EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalgias. Eur J Neurol. 2006;13(10):1066-1077.

    NINDS headache information page. National Institute of Neurological Disorders and Stroke website. Available at: https://www.ninds.nih.gov/Disorders/All-Disorders/Headache-Information-Page. Accessed November 10, 2017.

    Obermann M, Holle D, Naegel S, et al. Pharmacotherapy options for cluster headache. Expert Opin Pharmacother. 2015;16(8):1177-1184.

    Russell MB, Anderson PG, Thomsen LL. Familial occurrence of cluster headache. J Neurol Neurosurg Psychiatry. 1995;58(3):341-343.

    Van Vliet JA, Bahra A, Martin V, et al. Intranasal sumatriptan in cluster headache: randomized placebo-controlled double-blind study. Neurology. 2003;60(4):630-633.

    10/25/2010 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T116292/Cluster-headache: Francis GJ, Becker WJ, Pringsheim TM. Acute and preventive pharmacologic treatment of cluster headache. Neurology. 2010;75(5):463-473.

    Revision Information

    • Reviewer: EBSCO Medical Review Board Rimas Lukas, MD
    • Review Date: 11/2017
    • Update Date: 11/16/2015
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