12050 Health Library | Health and Wellness | Wellmont Health System
  • Ankylosing Spondylitis

    (Marie-Strumpell Disease)

    Definition

    Ankylosing spondylitis is a chronic inflammatory disease. It causes arthritis of the joints, mainly the spine and hips. Ankylosing spondylitis can also cause inflammation of the eyes, lungs, or heart valves.
    In severe cases, new bone may develop between the spinal bones. This can cause some areas of the spine to fuse. This fusion will decrease the flexibility and movement of the spine.
    Ankylosing Spondylitis
    Nucleus factsheet image
    Copyright © Nucleus Medical Media, Inc.

    Causes

    The cause of ankylosing spondylitis is not known. Some cases may be associated with a problem in a specific gene.

    Risk Factors

    Factors that increase your chance of ankylosing spondylitis include:

    Symptoms

    The severity of symptoms can vary from mild to very severe.
    Common symptoms may include:
      Stiffening and pain (arthritis) of the:
      • Lower back
      • Sacroiliac joint, where the back and hip meet, possibly radiating down the legs
    • Pain that is often worse at night
    • Stiffness that is worse in the morning
    • Symptom improvement with exercise or activity
    • Occasionally, pain and stiffness in other joints:
      • Knee
      • Upper back
      • Rib cage
      • Neck
      • Shoulders
      • Feet
    • Chest pain, which may suggest heart, heart valve, or lung problems
    • Eye pain, visual changes, increased tearing
    Less common symptoms may include:
    • Fatigue
    • Loss of appetite or weight loss
    • Fever
    • Numbness (if arthritic spurs compress the spinal nerves)

    Diagnosis

    The doctor will ask about your symptoms and medical history. A physical exam will be done. Diagnosis is based on common symptoms of ankylosing spondylitis, such as:
    • Dramatic loss of motion of the lower back and spine
    • Pain in the lower back
    • Limited chest expansion when taking deep breaths
    Blood tests may be done to check for:
    • HLA-B27 gene marker
    • Abnormalities in the blood
    • Signs of autoimmune disease
    Images of involved joints may be taken with:

    Treatment

    There is no cure for ankylosing spondylitis. Treatment is aimed at providing education and relieving the symptoms.
    Treatments may include:

    Medications

    Medication may help to control pain and inflammation. They may include:
    • Over-the-counter medication such as Nonsteroidal anti-inflammatory drugs (NSAIDs)
    • Prescription medication that suppresses the inflammation such as:
      • Corticosteroids
      • Disease-modifying antirheumatic drugs (DMARDS)
      • TNF-inhibitors

    Physical Therapy

    Physical therapy may help prevent progression and worsening of symptoms. Treatment may include:
    • Learning proper posture and the best positions for sleeping
    • Exercise program that includes:
      • Abdominal and back exercises (to decrease back stiffness and maintain good posture)
      • Stretching exercises
      • Water exercises
      • Breathing exercises (in cases where the rib cage is affected)

    Surgery

    In severe cases, hip or joint replacement surgery may be needed. It will be done to relieve pain and help you move around easier. In some instances, spinal surgery is needed to allow an upright posture.

    Prevention

    There are no guidelines for preventing ankylosing spondylitis because the cause is unknown.

    RESOURCES

    Arthritis Foundation http://www.arthritis.org/

    Spondylitis Association of America http://www.spondylitis.org/

    CANADIAN RESOURCES

    The Arthritis Society http://www.arthritis.ca/

    Canadian Spondyloarthritis Association http://www.spondylitis.ca/

    References

    Ankylosing spondylitis. Spondylitis Association of America website. Available at: http://www.spondylitis.org/about/as.aspx . Accessed January 3, 2012.

    Ankylosing spondylitis. University of Washington Orthopedics & Sports Medicine Department website. Available at: http://www.orthop.washington.edu/?q=patient-care/articles/arthritis/ankylosing-spondylitis.html . Updated February 11, 2005. Accessed July 8, 2009.

    Firestein ED et al. Kelley’s Textbook of Rheumatology . 8th ed. Philadelphia: Saunders, 2008.

    10/2/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : FDA approves new drug to treat psoriasis. US Food and Drug Administration website. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm183851.htm . Published September 25, 2009. Accessed October 2, 2009.

    Revision Information

  • Join WellZones today.

    Make a Change For LifeLearn more

    Wellmont LiveWell is creating a new tradition of wellness in the mountains by providing individuals with tools and encouragement to live healthier lifestyles.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease early and prevent heart attacks with HeartSHAPE® - a painless, non-invasive test that takes pictures of your heart to scan for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.


  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.