• Enzyme Potentiated Desensitization

    Alternate Names / Related Terms

    • EPD


    Principal Proposed Uses

    Other Proposed Uses

    • Literally hundreds of conditions.

    Safety Issues

    Whether or not EPD is effective, it does appear to be safe. No serious adverse reactions have been associated with its use. Although in theory allergic reactions could occur in response to EPD injections, the amount of allergen used in EPD is so much lower than the amount used in a normal "allergy shot" that these may not, in fact, occur.
    EPD proponents claim that there can be a temporary aggravation response that is part of the healing process; however, this has not been documented.


    1Radcliffe MJ, Lewith GT, Turner RG et al. Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study. BMJ. 2003;327:251-4.

    2 Enzyme Potentiated Desensitisation. http://www.naltd.co.uk/epdinfo.html . Accessed 8/9/2006.

    3 Galli E, Bassi MS, Mora E, et al. A double-blind randomized placebo-controlled trial with short-term beta-glucuronidase therapy in children with chronic rhinoconjunctivitis and/or asthma due to dust mite allergy. J Investig Allergol Clin Immunol . 2006;16:345-50.

    Revision Information

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