• Acute Interstitial Nephritis

    Definition

    Acute interstitial nephritis is a kidney disorder. The kidneys are unable to filter waste and fluid properly because of inflammation.
    Anatomy of the Kidney
    Glomerulonephritis
    Copyright © Nucleus Medical Media, Inc.

    Causes

    Acute interstitial nephritis can be caused by:

    Risk Factors

    Factors that may increase your chance of acute interstitial nephritis include:
    • Drug or medication use (adults)
    • Infection (children)

    Symptoms

    Acute interstitial nephritis may cause:
    • Decrease in urine output
    • Blood in urine
    • Side or loin pain
    • Swelling of the body
    • Nausea and vomiting
    • Loss of appetite
    • Weakness
    • Aching joints
    • Fever
    • Rash

    Diagnosis

    You will be asked about your symptoms and medical history. A physical exam will be done.
    Your bodily fluids and tissues may be tested. This can be done with:
    • Blood Tests
    • Urine tests
    • Kidney biopsy—may be done before certain medications are prescribed for treatment
    Images may be taken of your kidneys. This can be done with ultrasound.

    Treatment

    Talk with your doctor about the best treatment plan for you. Treatment will depend on the cause. For example, if medications are causing acute interstitial nephritis, your doctor may stop the medication, reduce the dosage, or prescribe a different one.
    Treatment options include the following:

    Medications

    Medications for acute interstitial nephritis may include:
    • Antibiotics for bacterial infection
    • Corticosteroids to reduce inflammation

    Dialysis

    Some people with interstitial nephritis need dialysis. During dialysis, a machine does the work of your kidneys by removing waste from the blood.

    Prevention

    To help reduce your chances of acute interstitial nephritis, your doctor may suggest you avoid certain medications, such as penicillin or NSAIDs.

    RESOURCES

    National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov

    National Kidney Foundation http://www.kidney.org

    CANADIAN RESOURCES

    Health Canada http://www.hc-sc.gc.ca

    Kidney Foundation of Canada http://www.kidney.ca

    References

    Acute interstitial nephritis. DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated December 9, 2014. Accessed June 1, 2016.

    Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician. 2003;67(12):2527-2534.

    Plakoglannis R, Nogid A. Acute interstitial nephritis associated with coadministration of vancomycin and ceftriaxone: Case series and review of the literature. Pharmacotherapy. 2007:27(10):1456-1461.

    Sierra F, Suzrez M, Rey M, Vela MF. Systematic review: Proton pump inhibitor-associated acute interstitial nephritis. Aliment Pharmaco Ther. 2007:26:545-553.

    Revision Information

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