• Risk Factors for Parkinson’s Disease

    A risk factor is something that increases your likelihood of getting a disease or condition.
    It is possible to develop Parkinson’s disease with or without the risk factors listed below. However, the more risk factors you have, the greater your likelihood of developing Parkinson’s disease. If you have a number of risk factors, ask your doctor what you can do to reduce your risk.
    Factors that may increase your chance of Parkinson's disease:
    Most people develop Parkinson’s disease after the age of 50 (age of onset ranges from 35-85). It is relatively unusual to develop Parkinson’s disease before the age of 40, although it is certainly possible.
    Men are about 1.5 times more likely than women to develop Parkinson’s disease.
    A number of genes have been associated with Parkinson's disease. Generally, people with these abnormal genes develop Parkinson's disease before the age of 50. This type of Parkinson's tends to run in families. However, the vast majority of Parkinson's disease occurs in older individuals (over the age of 60), and the role of genetics in these individuals is less clear.
    Research suggests that blacks and Asians have a slightly lower rate of Parkinson’s disease than Caucasians.
    Exposure to chemicals, such as herbicides and pesticides, is thought to increase your risk of developing Parkinson’s disease. You also have a greater risk of Parkinson’s disease if you live in a rural area, drink well water, or live on a farm. This may be due to an increased exposure to herbicides and pesticides.
    You may have a higher risk of Parkinson's disease if you had certain health conditions, such as:

    References

    Alves G, Forsaa EB, Pedersen KF, Dreetz Gjerstad M, Larsen JP. Epidemiology of Parkinson’s disease. J Neurol. 2008;255(suppl 5):18-32.

    Dachsel JC, Farrer MJ. LRRK2 and Parkinson disease. Arch Neurol. 2010;67(5):542-547.

    Kamel L. Epidemiology. Path’s from pesticides to Parkinson’s. Science. 2013;341(6147):722-723.

    Obeso JA, Rodriguez-Oroz MC, Goetz CG, et al. Missing pieces in the Parkinson’s disease puzzle. Nat Med. 2010;16(6):653-661.

    Parkinson disease. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115172/Parkinson-disease. Updated November 14, 2016. Accessed November 29, 2016.

    Parkinson disease. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/neurologic-disorders/movement-and-cerebellar-disorders/parkinson-disease. Updated September 2015. Accessed November 29, 2016.

    4/7/2014 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T115172/Parkinson-disease: Marras C, Hincapié CA, Kristman VL, et al. Systematic review of the risk of Parkinson's disease after mild traumatic brain injury: results of the international collaboration on mild traumatic brain injury prognosis. Arch Phys Med Rehabil. 2014;95(3S):S238-S244.

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