• Pentazocine

    (pen taz' oh seen)

    IMPORTANT WARNING:

    Pentazocine tablets should be taken by mouth. Do not try to dissolve and inject the tablets. Injecting pentazocine may cause serious health problems or death. Naloxone is added to the tablets so that people who inject dissolved tablets will not experience the desired effects of pentazocine.

    WHY is this medicine prescribed?

    Pentazocine is used to relieve moderate to severe pain. Pentazocine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

    HOW should this medicine be used?

    Pentazocine comes as a tablet to take by mouth. It usually is taken every 3 to 4 hours as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pentazocine exactly as directed.
    Pentazocine can be habit-forming. Do not take a larger dose, take it more often, or for a longer period than prescribed by your doctor.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking pentazocine,
    • tell your doctor and pharmacist if you are allergic to pentazocine, naloxone, any other medications, or any of the ingredients in pentazocine tablets. Ask your doctor or pharmacist for a list of the ingredients.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: other pain relievers; antidepressants [especially fluoxetine (Prozac)]; medications for cough, cold, or allergies; sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have or have ever had liver or kidney disease; a history of alcoholism or seizure disorders; lung or thyroid disease; heart disease; prostatic hypertrophy; or biliary or urinary problems.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pentazocine, call your doctor.
    • talk to your doctor about the safe use of this medication if you are 65 years of age or older. Older adults should not usually take pentazocine because it is not as safe as other medications that can be used to treat the same condition.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pentazocine.
    • you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
    • ask your doctor about the safe use of alcohol during your treatment with pentazocine. Alcohol can make the side effects of this medication worse.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    This medication usually is taken as needed. If your doctor has told you to take pentazocine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Pentazocine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • confusion
    • feeling very tired
    • dizziness
    • lightheadedness
    • drowsiness
    • mood changes
    • headache
    • upset stomach
    • vomiting
    • constipation
    • stomach pain
    • rash
    • difficulty urinating
    Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
    • difficulty breathing
    • fast heartbeat
    • fainting
    • hallucinations
    Pentazocine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor.
    Do not let anyone else take your medication. Pentazocine is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Talwin®[¶]
    • Talacen® (as a combination product containing Acetaminophen, Pentazocine)[¶]
    • Also available generically
    These branded products are no longer on the market and only generic alternatives are available.

    Acetaminophen

    (a set a mee' noe fen)

    IMPORTANT WARNING:

    Infants' Acetaminophen Product Changes
    Children's acetaminophen has been available as concentrated infant drops (containing 80 mg of acetaminophen per 0.8 mL of drops or 80 mg of acetaminophen per 1 mL of drops) and as a less concentrated liquid (containing 160 mg acetaminophen per 5 mL of liquid) for older children. The Food and Drug Administration (FDA) received reports of children who were given too much acetaminophen when their caregivers mistakenly used a more concentrated product in place of a less concentrated product. To prevent this type of mistake, the concentrated infant drops will no longer be manufactured for sale in the U.S. Instead, all liquid acetaminophen products for children under 12 years of age will contain 160 mg of acetaminophen in 5 mL of medication.
    Although the more concentrated products are no longer being manufactured, they may still be available in stores for some time, and you may already have these products in your home. You may continue to buy and to give your child the concentrated products, but you will need to be especially careful to follow directions so that you give your child the right amount of medication.
    Before you give your child acetaminophen, check the active ingredient section in the Drug Facts label on the package to see whether the medication is an older concentrated product containing 80 mg per 0.8 mL or a newer product containing 160 mg per 5 mL. Do not assume that a product with the word "new" on the package contains the new concentration because the word "new" may also appear on older products. Read the directions on each product label carefully and give only the amount of medication listed in the instructions on that package to your child. Do not just give your child the same amount of medication that you have given in the past, follow instructions that you have read on a different package in the past, or rely on dosing instructions from the Internet, old dosing charts, or family members. If your child's doctor prescribes acetaminophen for your child, be sure that he or she knows which product you will be using so that he or she can prescribe the correct dose.
    If you have an older concentrated product, it will probably come with a dropper, and if you have a newer product, it may come with an oral syringe. Only measure your child's medication with the device included in that package . Do not switch measuring devices between the old and new acetaminophen liquid products.
    Talk to your pharmacist or doctor if you have questions about these acetaminophen product changes.

    IMPORTANT WARNING:

    Taking too much acetaminophen can cause liver damage, sometimes serious enough to require liver transplantation or cause death. You might accidentally take too much acetaminophen if you do not follow the directions on the prescription or package label carefully, or if you take more than one product that contains acetaminophen.
    To be sure that you take acetaminophen safely, you should:
    • not take more than one product that contains acetaminophen at a time. Read the labels of all the prescription and nonprescription medications you are taking to see if they contain acetaminophen. Be aware that abbreviations such as APAP, AC, Acetaminophn, Acetaminoph, Acetaminop, Acetamin, or Acetam. may be written on the label in place of the word acetaminophen. Ask your doctor or pharmacist if you don't know if a medication that you are taking contains acetaminophen.
    • take acetaminophen exactly as directed on the prescription or package label. Do not take more acetaminophen or take it more often than directed, even if you still have fever or pain. Ask your doctor or pharmacist if you do not know how much medication to take or how often to take your medication. Call your doctor if you still have pain or fever after taking your medication as directed.
    • be aware that you should not take more than 4000 mg of acetaminophen per day. If you need to take more than one product that contains acetaminophen, it may be difficult for you to calculate the total amount of acetaminophen you are taking. Ask your doctor or pharmacist to help you.
    • tell your doctor if you have or have ever had liver disease.
    • tell your doctor if you drink 3 or more alcoholic drinks every day. Talk to your doctor about the safe use of alcohol while you are taking acetaminophen.
    • stop taking your medication and call your doctor right away if you think you have taken too much acetaminophen, even if you feel well.
    Talk to your pharmacist or doctor if you have questions about the safe use of acetaminophen or acetaminophen-containing products.

    WHY is this medicine prescribed?

    Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Acetaminophen may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints). Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.

    HOW should this medicine be used?

    Acetaminophen comes as a tablet, chewable tablet, capsule, suspension or solution (liquid), drops (concentrated liquid; removed from U.S. market), extended-release (long-acting) tablet, and orally disintegrating tablet (tablet that dissolves quickly in the mouth), to take by mouth, with or without food. Acetaminophen also comes as a suppository to use rectally. Acetaminophen is available without a prescription, but your doctor may prescribe acetaminophen to treat certain conditions. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
    If you are giving acetaminophen to your child, read the package label carefully to make sure that it is the right product for the age of the child. Do not give children acetaminophen products that are made for adults. Some products for adults and older children may contain too much acetaminophen for a younger child. Check the package label to find out how much medication the child needs. If you know how much your child weighs, give the dose that matches that weight on the chart. If you don't know your child's weight, give the dose that matches your child's age. Ask your child's doctor if you don't know how much medication to give your child.
    Acetaminophen comes in combination with other medications to treat cough and cold symptoms. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using two or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.
    Swallow the extended-release tablets whole; do not split, chew, crush, or dissolve them.
    Place the orally disintegrating tablet ('Meltaways') in your mouth and allow to dissolve or chew it before swallowing.
    Shake the suspension well before each use to mix the medication evenly. Always use the measuring cup or syringe provided by the manufacturer to measure each dose of the solution or suspension. Do not switch dosing devices between different products; always use the device that comes in the product packaging.
    To insert an acetaminophen suppository into the rectum, follow these steps:
    1. Remove the wrapper.
    2. Dip the tip of the suppository in water.
    3. Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)
    4. Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in infants and children and 1 inch (2.5 centimeters) in adults. Hold it in place for a few moments.
    5. Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.
    Stop taking acetaminophen and call your doctor if your symptoms get worse, you develop new or unexpected symptoms, including redness or swelling, your pain lasts for more than 10 days, or your fever gets worse or lasts more than 3 days. Also stop giving acetaminophen to your child and call your child's doctor if your child develops new symptoms, including redness or swelling, or your child's pain lasts for longer than 5 days, or fever get worse or lasts longer than 3 days.
    Do not give acetaminophen to a child who has a sore throat that is severe or does not go away, or that occurs along with fever, headache, rash, nausea, or vomiting. Call the child's doctor right away, because these symptoms may be signs of a more serious condition.

    Are there OTHER USES for this medicine?

    Acetaminophen may also be used in combination with aspirin and caffeine to relieve the pain associated with migraine headache.
    This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking acetaminophen,
    • tell your doctor and pharmacist if you are allergic to acetaminophen, any other medications, or any of the ingredients in the product. Ask your pharmacist or check the label on the package for a list of ingredients.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, or herbal products you are taking or plan to take. Be sure to mention anticoagulants ('blood thinners') such as warfarin (Coumadin); isoniazid (INH); certain medications for seizures including carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); medications for pain, fever, coughs, and colds; and phenothiazines (medications for mental illness and nausea). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have any serious medical condition.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking acetaminophen, call your doctor.
    • if you drink three or more alcoholic beverages every day, ask your doctor if you should take acetaminophen. Ask your doctor or pharmacist about the safe use of alcoholic beverages while taking acetaminophen.
    • you should know that combination acetaminophen products for cough and colds that contain nasal decongestants, antihistamines, cough suppressants, and expectorants should not be used in children younger than 2 years of age. Use of these medications in young children can cause serious and life-threatening effects or death. In children 2 through 11 years of age, combination cough and cold products should be used carefully and only according to the directions on the label.
    • if you have phenylketonuria (PKU, a inherited condition in which a special diet must be followed to prevent mental retardation), you should know that some brands of acetaminophen chewable tablets may be sweetened with aspartame. a source of phenylalanine.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    This medication is usually taken as needed. If your doctor has told you to take acetaminophen regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Acetaminophen may cause side effects.
    Some side effects can be serious. If you experience any of the following symptoms, stop taking acetaminophen and call your doctor immediately:
    • rash
    • hives
    • itching
    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
    • hoarseness
    • difficulty breathing or swallowing
    Acetaminophen may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    If someone takes more than the recommended dose of acetaminophen, get medical help immediately, even if the person does not have any symptoms. Symptoms of overdose may include:
    • nausea
    • vomiting
    • loss of appetite
    • sweating
    • extreme tiredness
    • unusual bleeding or bruising
    • pain in the upper right part of the stomach
    • yellowing of the skin or eyes
    • flu-like symptoms

    What OTHER INFORMATION should I know?

    Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking acetaminophen.
    Ask your pharmacist any questions you have about acetaminophen.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Acephen Rectal Suppository®
    • Feverall Rectal Suppository®
    • Mapap Rectal Suppository®
    • Neopap Supprettes Rectal Suppository®
    • Uniserts Rectal Suppository®
    • Aceta®[¶]
    • Actamin®
    • Adprin B®
    • Anacin®
    • Apacet®
    • Apara®
    • Apra®
    • Conacetol®
    • Dolono®
    • Feverall®
    • Genapap®
    • Genebs®
    • Gericet®
    • Halenol®
    • Infantaire®
    • Liquiprin®
    • Lopap®
    • Mapap®
    • Mardol®
    • Masophen®
    • Meda Cap®
    • Pain-Eze®
    • Panadol®
    • Panex®
    • Paramol®
    • Pediapap®
    • Q-Pap®
    • Redutemp®
    • Ridenol®
    • Silapap®
    • S-T Febrol®
    • Tactinal®
    • Tempra®
    • T-Panol®
    • Tycolene®
    • Tylenol®
    • Tylophen®
    • Uni-Ace®
    • Vitapap®
    • Aceta-Gesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[¶]
    • Actifed Plus® (as a combination product containing Acetaminophen, Pseudoephedrine, Triprolidine)
    • Acuflex® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Ali Flex® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Alka-Seltzer Plus Cold & Sinus® (as a combination product containing Acetaminophen, Phenylephrine)
    • Allay® (as a combination product containing Acetaminophen, Hydrocodone)[¶]
    • Alpain® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Anabar® (as a combination product containing Acetaminophen, Phenyltoloxamine, Salicylamide)[§]
    • Anacin® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Anexsia® (as a combination product containing Acetaminophen, Hydrocodone)
    • Anolor DH5® (as a combination product containing Acetaminophen, Hydrocodone)
    • Apapgesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Axocet® (as a combination product containing Acetaminophen, Butalbital)
    • Backprin® (as a combination product containing Acetaminophen, Caffeine, Magnesium Salicylate)
    • Bancap HC® (as a combination product containing Acetaminophen, Hydrocodone)
    • Bucet® (as a combination product containing Acetaminophen, Butalbital)[¶]
    • Butapap® (as a combination product containing Acetaminophen, Butalbital)
    • Butex Forte® (as a combination product containing Acetaminophen, Butalbital)
    • Cafgesic® (as a combination product containing Acetaminophen, Caffeine, Phenyltoloxamine, Salicylamide)[§]
    • Cephadyn® (as a combination product containing Acetaminophen, Butalbital)
    • Ceta Plus® (as a combination product containing Acetaminophen, Hydrocodone)
    • Cetazone T® (as a combination product containing Acetaminophen, Phenyltoloxamine, Salicylamide)[§]
    • Co-Apap® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine)
    • Codimal® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Co-Gesic® (as a combination product containing Acetaminophen, Hydrocodone)
    • Combiflex® (as a combination product containing Acetaminophen, Caffeine, Phenyltoloxamine, Salicylamide)[§]
    • Comtrex Cold and Cough® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
    • Contac Sinus® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Coricidin® (as a combination product containing Acetaminophen, Chlorpheniramine)
    • Dayquil® (as a combination product containing Acetaminophen, Dextromethorphan, Pseudoephedrine)
    • Dimetapp Cold And Fever® (as a combination product containing Acetaminophen, Brompheniramine, Pseudoephedrine)
    • Dolacet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Dolagesic® (as a combination product containing Acetaminophen, Hydrocodone)
    • Dolgic® (as a combination product containing Acetaminophen, Butalbital)
    • Dologesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Dolorex Forte® (as a combination product containing Acetaminophen, Hydrocodone)
    • Dristan Cold Non-Drowsy® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Drixoral Sinus® (as a combination product containing Acetaminophen, Dexbrompheniramine, Pseudoephedrine Extended Release Tablet)
    • Dryphen® (as a combination product containing Acetaminophen, Chlorpheniramine, Phenylephrine)
    • DuoCet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Duogesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Durabac® (as a combination product containing Acetaminophen, Caffeine, Phenyltoloxamine, Salicylamide)[§]
    • Durabac Forte® (as a combination product containing Acetaminophen, Caffeine, Magnesium Salicylate, Phenyltoloxamine)[§]
    • Duraflu® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Duratuss A® (as a combination product containing Acetaminophen, Guaifenesin, Phenylephrine)
    • Emagrin Forte® (as a combination product containing Acetaminophen, Caffeine, Guaifenesin, Phenylephrine)
    • Endocet® (as a combination product containing Acetaminophen, Oxycodone)
    • Excedrin® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Excedrin Back & Body® (as a combination product containing Acetaminophen, Aspirin)
    • Excedrin PM® (as a combination product containing Acetaminophen, Diphenhydramine)
    • Flextra® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Frenadol® (as a combination product containing Acetaminophen, Salicylamide)
    • Genace® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Genasec® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Gendecon® (as a combination product containing Acetaminophen, Chlorpheniramine, Phenylephrine)
    • Goody's Extra Strength® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Goody's PM® (as a combination product containing Acetaminophen, Diphenhydramine)
    • Hycet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Hycomed® (as a combination product containing Acetaminophen, Hydrocodone)
    • Hycomine Compound® (as a combination product containing Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine)
    • Hydrocet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Hydrogesic® (as a combination product containing Acetaminophen, Hydrocodone)
    • Hyflex® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Hy-Phen® (as a combination product containing Acetaminophen, Hydrocodone)
    • Kolephrin® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Levacet® (as a combination product containing Acetaminophen, Aspirin, Caffeine, Salicylamide)
    • Liquicet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Lobac® (as a combination product containing Acetaminophen, Phenyltoloxamine, Salicylamide)[§]
    • Lorcet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Lorsin® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Lortab® (as a combination product containing Acetaminophen, Hydrocodone)
    • Lurline PMS® (as a combination product containing Acetaminophen, Pamabrom, Vitamin B6)
    • Lynox® (as a combination product containing Acetaminophen, Oxycodone)
    • Magnacet® (as a combination product containing Acetaminophen, Oxycodone)
    • Major-gesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Margesic-H® (as a combination product containing Acetaminophen, Hydrocodone)
    • Marten-Tab® (as a combination product containing Acetaminophen, Butalbital)
    • Masophen PM® (as a combination product containing Acetaminophen, Diphenhydramine)
    • Maxidone® (as a combination product containing Acetaminophen, Hydrocodone)
    • Maxiflu DM® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Midol PMS® (as a combination product containing Acetaminophen, Pamabrom, Pyrilamine)
    • Migralam® (as a combination product containing Acetaminophen, Caffeine, Isometheptene)
    • MigraTen® (as a combination product containing Acetaminophen, Caffeine, Isometheptene)
    • Migrend® (as a combination product containing Acetaminophen, Caffeine, Isometheptene)
    • Narvox® (as a combination product containing Acetaminophen, Oxycodone)
    • Norco® (as a combination product containing Acetaminophen, Hydrocodone)
    • Novagesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • NyCair® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine)
    • NyQuil Cold/Flu Relief® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
    • Oncet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Ornex® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Pamprin® (as a combination product containing Acetaminophen, Pamabrom, Pyrilamine)
    • Panacet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Panlor® (as a combination product containing Acetaminophen, Hydrocodone)
    • Panritis Forte® (as a combination product containing Acetaminophen, Salicylamide)
    • Percocet® (as a combination product containing Acetaminophen, Oxycodone)
    • Percogesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[¶]
    • Perisine® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Perloxx® (as a combination product containing Acetaminophen, Oxycodone)
    • Phenagesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Phenapap® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Phenflu DM® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Phenylgesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Phlemgesic® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Phrenilin® (as a combination product containing Acetaminophen, Butalbital)
    • Polygesic® (as a combination product containing Acetaminophen, Hydrocodone)
    • Premesyn PMS® (as a combination product containing Acetaminophen, Pamabrom, Pyrilamine)
    • Primlev® (as a combination product containing Acetaminophen, Oxycodone)
    • Procet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Prodrin® (as a combination product containing Acetaminophen, Caffeine, Isometheptene)
    • Promacet® (as a combination product containing Acetaminophen, Butalbital)
    • Prominol® (as a combination product containing Acetaminophen, Butalbital)
    • Protid® (as a combination product containing Acetaminophen, Chlorpheniramine, Phenylephrine)
    • Q-Gesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Relagesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Repan CF® (as a combination product containing Acetaminophen, Butalbital)
    • Rhinoflex® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Rhinogesic® (as a combination product containing Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide)
    • Robitussin Cold Cough and Flu® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Roxicet® (as a combination product containing Acetaminophen, Oxycodone)
    • Saleto® (as a combination product containing Acetaminophen, Aspirin, Caffeine, Salicylamide)
    • Sedapap® (as a combination product containing Acetaminophen, Butalbital)[¶]
    • Simplet® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Sinarest® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Sine-Aid® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Sine-Off Sinus and Cold® (as a combination product containing Acetaminophen, Chlorpheniramine, Phenylephrine)
    • Singlet® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Sinumed® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Sinus Aid® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Sinutab® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Sominex Pain Relief® (as a combination product containing Acetaminophen, Diphenhydramine)
    • Staflex® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Stagesic® (as a combination product containing Acetaminophen, Hydrocodone)
    • Sudafed PE Cold & Cough® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Sudafed PE Sinus Headache® (as a combination product containing Acetaminophen, Phenylephrine)
    • Sudogest® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Supac® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Suphedrin Sinus® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Talacen® (as a combination product containing Acetaminophen, Pentazocine)
    • Tavist Allergy/Sinus/Headache® (as a combination product containing Acetaminophen, Clemastine, Pseudoephedrine)
    • Tavist Sinus® (as a combination product containing Acetaminophen, Pseudoephedrine)
    • Taxadone® (as a combination product containing Acetaminophen, Oxycodone)
    • Tencon® (as a combination product containing Acetaminophen, Butalbital)
    • T-Gesic® (as a combination product containing Acetaminophen, Hydrocodone)
    • Theraflu Sore Throat® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Triaminic Cold And Fever® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine)
    • Triaprin® (as a combination product containing Acetaminophen, Butalbital)[¶]
    • Tricom® (as a combination product containing Acetaminophen, Chlorpheniramine, Pseudoephedrine)
    • Tylefon® (as a combination product containing Acetaminophen, Chlorzoxazone)
    • Tylenol Cold® (as a combination product containing Acetaminophen, Dextromethorphan, Pseudoephedrine)
    • Tylox® (as a combination product containing Acetaminophen, Oxycodone)
    • Ugesic® (as a combination product containing Acetaminophen, Hydrocodone)
    • Ultracet® (as a combination product containing Acetaminophen, Tramadol)
    • Uni-Case® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Uni-Perr® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Unisom With Pain Relief® (as a combination product containing Acetaminophen, Diphenhydramine)
    • Valorin Extra® (as a combination product containing Acetaminophen, Caffeine)
    • Vanacet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Vanquish® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Vendone® (as a combination product containing Acetaminophen, Hydrocodone)
    • Vicks 44 Cold, Flu and Cough® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine)
    • Vicodin® (as a combination product containing Acetaminophen, Hydrocodone)
    • Vidone® (as a combination product containing Acetaminophen, Hydrocodone)
    • Vistra® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Vitoxapap® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Xodol® (as a combination product containing Acetaminophen, Hydrocodone)
    • Xolox® (as a combination product containing Acetaminophen, Oxycodone)
    • Zamicet® (as a combination product containing Acetaminophen, Hydrocodone)
    • Zflex® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Zgesic® (as a combination product containing Acetaminophen, Phenyltoloxamine)[§]
    • Zydone® (as a combination product containing Acetaminophen, Hydrocodone)
    • Also available generically

    Other Names

    • APAP
    • N-acetyl-para-aminophenol
    • Paracetamol
    § These products are not currently approved by the FDA for safety, effectiveness, and quality. Federal law generally requires that prescription drugs in the U.S. be shown to be both safe and effective prior to marketing. Please see the FDA website for more information on unapproved drugs ( http://www.fda.gov/AboutFDA/Transparency/Basics/ucm213030.htm) and the approval process ( http://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm054420.htm).
    These branded products are no longer on the market and only generic alternatives are available.

    Aspirin

    (as' pir in)

    WHY is this medicine prescribed?

    Prescription aspirin is used to relieve the symptoms of rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by breakdown of the lining of the joints), systemic lupus erythematosus (condition in which the immune system attacks the joints and organs and causes pain and swelling) and certain other rheumatologic conditions (conditions in which the immune system attacks parts of the body). Nonprescription aspirin is used to reduce fever and to relieve mild to moderate pain from headaches, menstrual periods, arthritis, colds, toothaches, and muscle aches. Nonprescription aspirin is also used to prevent heart attacks in people who have had a heart attack in the past or who have angina (chest pain that occurs when the heart does not get enough oxygen). Nonprescription aspirin is also used to reduce the risk of death in people who are experiencing or who have recently experienced a heart attack. Nonprescription aspirin is also used to prevent ischemic strokes (strokes that occur when a blood clot blocks the flow of blood to the brain) or mini-strokes (strokes that occur when the flow of blood to the brain is blocked for a short time) in people who have had this type of stroke or mini-stroke in the past. Aspirin will not prevent hemorrhagic strokes (strokes caused by bleeding in the brain). Aspirin is in a group of medications called salicylates. It works by stopping the production of certain natural substances that cause fever, pain, swelling, and blood clots.
    Aspirin is also available in combination with other medications such as antacids, pain relievers, and cough and cold medications. This monograph only includes information about the use of aspirin alone. If you are taking a combination product, read the information on the package or prescription label or ask your doctor or pharmacist for more information.

    HOW should this medicine be used?

    Prescription aspirin comes as an extended-release tablet (tablet that releases medication slowly over a period of time). Nonprescription aspirin comes as a regular tablet, an enteric-coated, delayed-release tablet (tablet that first begins to release medication some time after it is taken), a chewable tablet, powder, and a gum to take by mouth and a suppository to use rectally. Prescription aspirin is usually taken two or more times a day. Nonprescription aspirin is usually taken once a day to lower the risk of a heart attack or stroke. Nonprescription aspirin is usually taken every 4 to 6 hours as needed to treat fever or pain. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take aspirin exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.
    Swallow the extended-release tablets whole with a full glass of water. Do not break, crush, or chew them.
    Swallow the tablets with a full glass of water.
    Chewable aspirin tablets may be chewed, crushed, or swallowed whole. Drink a full glass of water, immediately after taking these tablets.
    Ask a doctor before you give aspirin to your child or teenager. Aspirin may cause Reye's syndrome (a serious condition in which fat builds up on the brain, liver, and other body organs) in children and teenagers, especially if they have a virus such as chicken pox or the flu.
    If you have had oral surgery or surgery to remove your tonsils in the last 7 days, talk to your doctor about which types of aspirin are safe for you.
    Delayed-release tablets begin to work some time after they are taken. Do not take delayed-release tablets for fever or pain that must be relieved quickly.
    Stop taking aspirin and call your doctor if your fever lasts longer than 3 days, if your pain lasts longer than 10 days, or if the part of your body that was painful becomes red or swollen. You may have a condition that must be treated by a doctor.
    To insert an aspirin suppository into the rectum, follow these steps:
    1. Remove the wrapper.
    2. Dip the tip of the suppository in water.
    3. Lie down on your left side and raise your right knee to your chest. (If you are left-handed, lie on your right side and raise your left knee.)
    4. Using your finger, insert the suppository into the rectum, about 1/2 to 1 inch (1.25 to 2.5 centimeters) in infants and children and 1 inch (2.5 centimeters) in adults. Hold it in place for a few moments.
    5. Do not stand up for at least 15 minutes. Then wash your hands thoroughly and resume your normal activities.

    Are there OTHER USES for this medicine?

    Aspirin is also sometimes used to treat rheumatic fever (a serious condition that may develop after a strep throat infection and may cause swelling of the heart valves) and Kawasaki disease (an illness that may cause heart problems in children). Aspirin is also sometimes used to lower the risk of blood clots in patients who have artificial heart valves or certain other heart conditions and to prevent certain complications of pregnancy.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking aspirin,
    • tell your doctor and pharmacist if you are allergic to aspirin, other medications for pain or fever, tartrazine dye, or any other medications.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetazolamide (Diamox); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners') such as warfarin (Coumadin) and heparin; beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); diuretics ('water pills'); medications for diabetes or arthritis; medications for gout such as probenecid and sulfinpyrazone (Anturane); methotrexate (Trexall); other nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen (Aleve, Naprosyn); phenytoin (Dilantin); and valproic acid (Depakene, Depakote). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
    • if you are taking aspirin on a regular basis to prevent heart attack or stroke, do not take ibuprofen (Advil, Motrin) to treat pain or fever without talking to your doctor. Your doctor will probably tell you to allow some time to pass between taking your daily dose of aspirin and taking a dose of ibuprofen.
    • tell your doctor if you have or have ever had asthma, frequent stuffed or runny nose, or nasal polyps (growths on the linings of the nose). If you have these conditions, there is a risk that you will have an allergic reaction to aspirin. Your doctor may tell you that you should not take aspirin.
    • tell your doctor if you often have heartburn, upset stomach, or stomach pain and if you have or have ever had ulcers, anemia, bleeding problems such as hemophilia, or kidney or liver disease.
    • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking aspirin, call your doctor. Aspirin may harm the fetus and cause problems with delivery if it is taken during the last few months of pregnancy.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking aspirin.
    • if you drink three or more alcoholic drinks every day, ask your doctor if you should take aspirin or other medications for pain and fever.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    If your doctor has told you to take aspirin on a regular basis and you miss a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Aspirin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • nausea
    • vomiting
    • stomach pain
    • heartburn
    Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
    • hives
    • rash
    • swelling of the eyes, face, lips, tongue, or throat
    • wheezing or difficulty breathing
    • hoarseness
    • fast heartbeat
    • fast breathing
    • cold, clammy skin
    • ringing in the ears
    • loss of hearing
    • bloody vomit
    • vomit that looks like coffee grounds
    • bright red blood in stools
    • black or tarry stools
    Aspirin may cause other side effects. Call your doctor if you experience any unusual problems while you are taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Store aspirin suppositories in a cool place or in a refrigerator. Throw away any medication that is outdated or no longer needed and any tablets that have a strong vinegar smell. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • burning pain in the throat or stomach
    • vomiting
    • decreased urination
    • fever
    • restlessness
    • irritability
    • talking a lot and saying things that do not make sense
    • fear or nervousness
    • dizziness
    • double vision
    • uncontrollable shaking of a part of the body
    • confusion
    • abnormally excited mood
    • hallucination (seeing things or hearing voices that are not there)
    • seizures
    • drowsiness
    • loss of consciousness for a period of time

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor.
    If you are taking prescription aspirin, do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Acuprin®
    • Anacin® Aspirin Regimen
    • Ascriptin®
    • Aspergum®
    • Aspidrox®
    • Aspir-Mox®
    • Aspirtab®
    • Aspir-trin®
    • Bayer® Aspirin
    • Bufferin®
    • Buffex®
    • Easprin®
    • Ecotrin®
    • Empirin®
    • Entaprin®
    • Entercote®
    • Fasprin®
    • Genacote®
    • Gennin-FC®
    • Genprin®
    • Halfprin®
    • Magnaprin®
    • Miniprin®
    • Minitabs®
    • Ridiprin®
    • Sloprin®
    • Uni-Buff®
    • Uni-Tren®
    • Valomag®
    • Zorprin®
    • Alka-Seltzer® (as a combination product containing Aspirin, Citric Acid, Sodium Bicarbonate)
    • Alka-Seltzer® Extra Strength (as a combination product containing Aspirin, Citric Acid, Sodium Bicarbonate)
    • Alka-Seltzer® Morning Relief (as a combination product containing Aspirin, Caffeine)
    • Alka-Seltzer® Plus Flu (as a combination product containing Aspirin, Chlorpheniramine, Dextromethorphan)
    • Alka-Seltzer® PM (as a combination product containing Aspirin, Diphenhydramine)
    • Alor® (as a combination product containing Aspirin, Hydrocodone)
    • Anacin® (as a combination product containing Aspirin, Caffeine)
    • Anacin® Advanced Headache Formula (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Aspircaf® (as a combination product containing Aspirin, Caffeine)
    • Axotal® (as a combination product containing Aspirin, Butalbital)
    • Azdone® (as a combination product containing Aspirin, Hydrocodone)
    • Bayer® Aspirin Plus Calcium (as a combination product containing Aspirin, Calcium Carbonate)
    • Bayer® Aspirin PM (as a combination product containing Aspirin, Diphenhydramine)
    • Bayer® Back and Body Pain (as a combination product containing Aspirin, Caffeine)
    • BC Headache (as a combination product containing Aspirin, Caffeine, Salicylamide)
    • BC Powder (as a combination product containing Aspirin, Caffeine, Salicylamide)
    • Damason-P® (as a combination product containing Aspirin, Hydrocodone)
    • Emagrin® (as a combination product containing Aspirin, Caffeine, Salicylamide)
    • Endodan® (as a combination product containing Aspirin, Oxycodone)
    • Equagesic® (as a combination product containing Aspirin, Meprobamate)
    • Excedrin® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Excedrin® Back & Body (as a combination product containing Acetaminophen, Aspirin)
    • Goody's® Body Pain (as a combination product containing Acetaminophen, Aspirin)
    • Levacet® (as a combination product containing Acetaminophen, Aspirin, Caffeine, Salicylamide)
    • Lortab ASA® (as a combination product containing Aspirin, Hydrocodone)
    • Micrainin® (as a combination product containing Aspirin, Meprobamate)
    • Momentum® (as a combination product containing Aspirin, Phenyltoloxamine)
    • Norgesic® (as a combination product containing Aspirin, Caffeine, Orphenadrine)
    • Orphengesic® (as a combination product containing Aspirin, Caffeine, Orphenadrine)
    • Panasal® (as a combination product containing Aspirin, Hydrocodone)
    • Percodan® (as a combination product containing Aspirin, Oxycodone)
    • Robaxisal® (as a combination product containing Aspirin, Methocarbamol)
    • Roxiprin® (as a combination product containing Aspirin, Oxycodone)
    • Saleto® (as a combination product containing Acetaminophen, Aspirin, Caffeine, Salicylamide)
    • Soma® Compound (as a combination product containing Aspirin, Carisoprodol)
    • Soma® Compound with Codeine (as a combination product containing Aspirin, Carisoprodol, Codeine)
    • Supac® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Synalgos-DC® (as a combination product containing Aspirin, Caffeine, Dihydrocodeine)
    • Talwin® Compound (as a combination product containing Aspirin, Pentazocine)
    • Vanquish® (as a combination product containing Acetaminophen, Aspirin, Caffeine)
    • Also available generically

    Other Names

    • Acetylsalicylic acid
    • ASA
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