• Enfuvirtide Injection

    (en fyoo' vir tide)

    WHY is this medicine prescribed?

    Enfuvirtide is used in combination with other medications to treat human immunodeficiency virus (HIV) infection in people who have not responded well enough to other antiviral medications. Enfuvirtide is in a class of medications called HIV fusion inhibitors. It works by stopping HIV from infecting healthy cells. Enfuvirtide does not cure HIV and may not prevent you from developing HIV-related illnesses. Enfuvirtide does not prevent the spread of HIV to other people.

    HOW should this medicine be used?

    Enfuvirtide comes as a powder to be mixed with sterile water and injected subcutaneously (under the skin). It is usually injected twice a day. To help you remember to inject enfuvirtide, inject it at about the same times each day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use enfuvirtide exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
    Enfuvirtide controls HIV but does not cure it. Continue to use enfuvirtide even if you feel well. Do not stop using enfuvirtide without talking to your doctor. If you miss doses or stop using enfuvirtide, your condition may become more difficult to treat.When your supply of enfuvirtide starts to run low, get more from your doctor or pharmacist.
    You will receive your first dose of enfuvirtide in your doctor's office. After that, you can inject enfuvirtide yourself or have a friend or relative perform the injections. Your doctor will train the person who will be injecting the medication, and will test him to be sure he can give the injection correctly. Be sure that you and the person who will be giving the injections read the manufacturer's information for the patient that comes with enfuvirtide before you use it for the first time at home.
    You can inject enfuvirtide anywhere on the front of your thighs, your stomach, or upper arms. Do not inject enfuvirtide in or near your navel (belly button) or in any area directly under a belt or waistband; near the elbow, knee, groin, the lower or inner buttocks; or directly over a blood vessel. To reduce the chances of soreness, choose a different area for each injection. Keep track of the areas where you inject enfuvirtide, and do not give an injection into the same area two times in a row. Use your fingertips to check your chosen area for hard bumps under the skin. Never inject enfuvirtide into any skin that has a tattoo, scar, bruise, mole, a burn site, or has had a reaction to a previous injection of enfuvirtide.
    Never reuse needles, syringes, vials of enfuvirtide, or vials of sterile water. Dispose of used needles and syringes in a puncture-resistant container. Do not put them in a trash can. You can dispose of used alcohol pads and vials in the trash, but if you see blood on an alcohol pad, put it in the puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.
    Before preparing an enfuvirtide dose, wash your hands with soap and water. After you wash your hands, do not touch anything except the medication, supplies, and the area where you will inject the medication.
    Ask your pharmacist or doctor for a copy of the manufacturer's injection information for the patient. Carefully read the manufacturer's instructions to learn how to prepare and inject your dose. Ask your doctor or pharmacist if you have questions about how to inject enfuvirtide.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before using enfuvirtide,
    • tell your doctor and pharmacist if you are allergic to enfuvirtide, mannitol, or any other medications.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention anticoagulants ('blood thinners') such as warfarin (Coumadin).
    • tell your doctor if you smoke, if you use or have ever used intravenous (injected into the vein) street drugs, and if you have or have ever had hemophilia or any other blood-clotting or bleeding condition, or lung disease.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using enfuvirtide, call your doctor. You should not breast-feed if you are infected with HIV or if you are using enfuvirtide.
    • you should know that enfuvirtide may make you dizzy. Do not drive a car or operate machinery until you know how this medication affects you.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    Inject the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not inject a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Enfuvirtide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • itching, swelling, pain, tingling, discomfort, tenderness, redness, bruising, hardened area of skin, or bumps in the place where you injected enfuvirtide
    • difficulty falling or staying asleep
    • depression
    • nervousness
    • tiredness
    • weakness
    • muscle pain
    • nausea
    • loss of appetite
    • changes in ability to taste food
    • weight loss
    • diarrhea
    • constipation
    • flu-like symptoms
    • runny nose with sinus pain
    • warts or cold sores
    • swollen glands
    • painful, red, or teary eyes
    Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
    • severe pain, oozing, swelling, warmth, or redness in the place you injected enfuvirtide
    • rash
    • fever
    • vomiting
    • nausea with rash and/or fever
    • chills
    • fainting
    • dizziness
    • blurred vision
    • cough
    • difficulty breathing
    • blood in urine
    • swollen feet
    • fast breathing
    • shortness of breath
    • pain, burning, numbness, or tingling in feet or legs
    • pale or fatty stools
    • yellowing of skin or eyes
    Enfuvirtide may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication and the sterile water that comes with it in the containers they came in, tightly closed, and out of reach of children. Store them at room temperature and away from excess heat and moisture (not in the bathroom). If they can not be stored at room temperature, put them in the refrigerator. If you mix the medication and sterile water in advance, store the mixture in the vial in the refrigerator for up to 24 hours. Never store mixed medication in the syringe. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to enfuvirtide.
    Before having any laboratory test, tell your doctor and the laboratory personnel that you are using enfuvirtide.
    Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Fuzeon®

    Other Names

    • T-20
    • Pentafuside
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