2011501564 Health Library | Health and Wellness | Wellmont Health System
  • Norethindrone

    (nor eth in' drone)

    WHY is this medicine prescribed?

    Norethindrone is used to treat endometriosis, a condition in which the type of tissue that lines the uterus (womb) grows in other areas of the body and causes pain, heavy or irregular menstruation (periods), and other symptoms. Norethindrone is also used to treat abnormal periods or bleeding and to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Norethindrone is also used as a test to see if the body is producing certain female hormones (natural substances that affect the uterus). Norethindrone is in a class of medications called progestins. It works by stopping the lining of the uterus from growing and by causing the uterus to produce certain hormones.
    Norethindrone is also used to prevent pregnancy. Norethindrone is sold under different brand names and is taken in smaller amounts when it used to prevent pregnancy. This monograph does not include information on the use of norethindrone to prevent pregnancy. If you would like more information on that use of norethindrone, read the monograph called ''Progestin Only Oral Contraceptives.''

    HOW should this medicine be used?

    Norethindrone comes as a tablet to take by mouth. Norethindrone is taken on different schedules that depend on the condition that is being treated and on how well norethindrone works to treat the conditions. When norethindrone is used to treat endometriosis, it is usually taken once a day for 6 to 9 months or until breakthrough bleeding becomes bothersome. When norethindrone is used to bring on a normal cycle in women who have stopped menstruating, it is usually taken once a day for 5 to 10 days during the second half of the planned menstrual cycle. To help you remember to take norethindrone, take it at around the same time of day every day that you are scheduled to take it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take norethindrone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
    If you are taking norethindrone for endometriosis, your doctor will probably start you on a low dose of norethindrone and gradually increase your dose, not more than once every 2 weeks.
    Norethindrone may control your condition but will not cure it. Continue to take norethindrone even if you feel well. Do not stop taking norethindrone without talking to your doctor.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking norethindrone,
    • tell your doctor and pharmacist if you are allergic to norethindrone, oral contraceptives ('birth control pills'), or any other medications.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention medications for seizures such as carbamazepine (Tegretol),phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); and rifampin (Rifadin, Rimactane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have recently had surgery or have been unable to move around for any reason and if you have or have ever had breast cancer; unexplained vaginal bleeding; a missed abortion (a pregnancy that ended when the unborn child died in the uterus but was not expelled from the body); blood clots in your legs, lungs, brain, or eyes; stroke or mini-stroke; coronary artery disease (clogged blood vessels leading to the heart); chest pain; a heart attack; thrombophilia (a condition in which the blood clots more easily); seizures; migraine headaches; depression; asthma; high cholesterol; diabetes; or heart, kidney, or liver disease.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking norethindrone, call your doctor immediately. Norethindrone should never be used to test for pregnancy.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking norethindrone.
    • tell your doctor if you smoke cigarettes. Smoking may increase the risk that you will develop serious side effects of norethindrone.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Norethindrone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • irregular vaginal bleeding or spotting
    • changes in menstrual flow
    • enlarged or tender breasts
    • upset stomach
    • weight changes
    • difficulty falling asleep or staying asleep
    • acne
    • growth of hair on face
    Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
    • loss of vision
    • blurred vision
    • double vision
    • bulging eyes
    • migraine headache
    • pain, warmth, or heaviness in the back of the lower leg
    • shortness of breath
    • coughing up blood
    • sudden sharp or crushing chest pain
    • heaviness in chest
    • slow or difficult speech
    • dizziness or faintness
    • weakness or numbness of an arm or leg
    • swelling of the arms, hands, feet, ankles, or lower legs
    • yellowing of the skin or eyes
    • depression
    • mood swings
    • brown patches on the face
    • missed periods
    • sudden, severe pain in the abdomen (area between the chest and waist)
    • hives
    • rash
    • itching
    • difficulty breathing or swallowing
    Norethindrone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to norethindrone.
    Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking norethindrone.
    Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Aygestin®

    Other Names

    • Norethisterone acetate
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