• Arsenic Trioxide Injection

    (ar' se nik trye ox' ide)

    IMPORTANT WARNING:

    Arsenic trioxide should be given only under the supervision of a doctor who has experience in treating people who have leukemia (cancer of the white blood cells).
    Arsenic trioxide may cause a serious or life-threatening group of symptoms called APL differentiation syndrome. Your doctor will monitor you carefully to see whether you are developing this syndrome. Your doctor may ask you to weigh yourself every day during the first few weeks of your treatment because weight gain is a symptom of APL differentiation syndrome. If you experience any of the following symptoms, call your doctor immediately: fever, weight gain, shortness of breath, labored breathing, chest pain, or cough. At the first sign that you are developing APL differentiation syndrome, your doctor will prescribe one or more medications to treat the syndrome.
    Arsenic trioxide may cause QT prolongation (heart muscles take longer to recharge between beats due to an electrical disturbance), which can cause serious or life-threatening heart rhythm problems. Before you begin treatment with arsenic trioxide, your doctor will order an electrocardiogram (ECG; test that records the electrical activity of the heart) and other tests to see whether you already have an electrical disturbance in your heart or are at higher than usual risk of developing this condition. Your doctor will monitor you closely and will order an ECG and other tests during your treatment with arsenic trioxide. Tell your doctor if you have or have ever had QT prolongation, heart failure, irregular heartbeat, or low levels of potassium or magnesium in your blood. Also tell your doctor if you are taking any of the following medications: amiodarone (Cordarone), amphotericin (Abelcet, Amphotec, Fungizone), cisapride (Propulsid), disopyramide (Norpace), diuretics ('water pills'), dofetilide (Tikosyn), erythromycin (E.E.S., E-Mycin, Erythrocin), moxifloxacin (Avelox), pimozide (Orap), procainamide (Procanbid, Pronestyl), quinidine (Quinidex), sotalol (Betapace, Betapace AF), sparfloxacin (Zagam), thioridazine (Mellaril), and ziprasidone (Geodon). Call your doctor immediately if you have an irregular or fast heartbeat or if you faint during your treatment with arsenic trioxide.
    Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to arsenic trioxide.
    Talk to your doctor about the risks of taking arsenic trioxide.

    WHY is this medicine prescribed?

    Arsenic trioxide is used to treat acute promyelocytic leukemia (APL; a type of cancer in which there are too many immature blood cells in the blood and bone marrow) in people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with other types of chemotherapy. Arsenic trioxide is in a class of medications called anti-neoplastics. It works by slowing or stopping the growth of cancer cells.

    HOW should this medicine be used?

    Arsenic trioxide comes as a solution (liquid) to be injected into a vein by a doctor or nurse in a medical office or clinic. Arsenic trioxide is usually injected over 1 to 2 hours, but it may be injected over as long as 4 hours if side effects are experienced during the infusion. It is usually given once a day for a specific period of time.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before receiving arsenic trioxide injection,
    • tell your doctor and pharmacist if you are allergic to arsenic trioxide or any other medications.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have or have ever had kidney disease.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Talk to your doctor about using birth control to prevent pregnancy during your treatment with arsenic trioxide. If you become pregnant while receiving arsenic trioxide, call your doctor. Arsenic trioxide may harm the fetus.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving arsenic trioxide.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What SIDE EFFECTS can this medicine cause?

    Arsenic trioxide injection may cause an increase in your blood sugar. Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):
    • extreme thirst
    • frequent urination
    • extreme hunger
    • weakness
    • blurred vision
    If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Get medical care immediately if you have any of these symptoms:
    • dry mouth
    • nausea and vomiting
    • shortness of breath
    • breath that smells fruity
    • decreased consciousness
    Arsenic trioxide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • excessive tiredness
    • dizziness
    • headache
    • diarrhea
    • swelling of the arms, hands, feet, ankles, or lower legs
    • rash
    • itching
    Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
    • unusual bruising or bleeding
    • vomit that is bloody or that looks like coffee grounds
    • stool that is black and tarry or contains bright red blood
    • decreased urination
    • hives
    • seizures
    Arsenic trioxide injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • seizures
    • muscle weakness
    • confusion

    What OTHER INFORMATION should I know?

    Ask your doctor or pharmacist if you have any questions about arsenic trioxide injection.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Trisenox®
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