• Nebivolol

    (ne biv' oh lol)

    WHY is this medicine prescribed?

    Nebivolol is used alone or in combination with other medications to treat high blood pressure. Nebivolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.

    HOW should this medicine be used?

    Nebivolol comes as a tablet to take by mouth. It is usually taken with or without food once a day. To help you remember to take nebivolol, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take nebivolol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
    Your doctor may start you on a low dose of nebivolol and gradually increase your dose not more than once every 2 weeks.
    Nebivolol controls high blood pressure but does not cure it. It may take 2 weeks before the full benefit of nebivolol is seen in blood pressure readings. Continue to take nebivolol even if you feel well. Do not stop taking nebivolol without talking to your doctor. If you suddenly stop taking nebivolol it may cause angina (chest pain), heart attack, or irregular heartbeat. Your doctor will probably decrease your dose gradually over 1 to 2 weeks.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking nebivolol,
    • tell your doctor and pharmacist if you are allergic to nebivolol, acebutolol (Sectral), atenolol (Tenormin, in Tenoretic), betaxolol (Kerlone), bisoprolol (Zebeta, in Ziac), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), pindolol, propranolol (Inderal, InnoPran XL, in Inderide), sotalol (Betapace, Betapace AF, Sorine), timolol (Blocadren, in Timolide), any other medications, or any of the ingredients in nebivolol tablets. Ask your pharmacist for a list of the ingredients.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); beta blockers such as acebutolol (Sectral), atenolol (Tenormin, in Tenoretic), betaxolol (Kerlone), bisoprolol (Zebeta, in Ziac), carvedilol (Coreg), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), pindolol, propranolol (Inderal, InnoPran XL, in Inderide), sotalol (Betapace, Betapace AF, Sorine), timolol (Blocadren, in Timolide); bupropion (Wellbutrin); calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac, others) and verapamil (Calan, Isoptin, Verelan); chlorpheniramine (antihistamine in allergy and cold medications); cimetidine (Tagamet); clomipramine (Anafranil); clonidine (Catapres); digoxin (Digitek, Lanoxicaps, Lanoxin); disopyramide (Norpace); duloxetine (Cymbalta); fluoxetine (Prozac, Sarafem); haloperidol (Haldol); insulin; oral medications for diabetes; methadone (Dolophine, Methadose); paroxetine (Paxil); propafenone (Rythmol); quinidine (Quinaglute, Quinidex); reserpine; ritonavir (Norvir, in Kaletra); and sildenafil (Revatio, Viagra). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have a slow heart rate, heart or liver disease, or heart failure. Your doctor may tell you not to take nebivolol.
    • tell your doctor if you have or have ever had asthma or other lung diseases, diabetes, overactive thyroid gland (hyperthyroidism), problems with blood circulation, kidney disease, severe allergies, or pheochromocytoma (a tumor that develops on a gland near the kidneys and may cause high blood pressure and fast heart rate).
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking nebivolol, call your doctor.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking nebivolol.
    • you should know that nebivolol may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
    • you should know that if you have allergic reactions to different substances, your reactions may be worse while you are using nebivolol, and your allergic reactions may not respond to the usual doses of injectable epinephrine.

    What SPECIAL DIETARY instructions should I follow?

    If your doctor prescribes a low-salt or low-sodium diet, follow those directions carefully.

    What should I do IF I FORGET to take a dose?

    Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Nebivolol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • headache
    • tiredness
    • weakness
    • dizziness
    • diarrhea
    • nausea
    • stomach pain
    • difficulty falling asleep or staying asleep
    • numbness, burning, or tingling in the hands, arms, feet, or legs
    Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
    • chest pain
    • slow heart rate
    • difficulty breathing
    • unusual weight gain
    • rash
    • swelling of the hands, feet, ankles, or lower legs
    Nebivolol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • slow heart rate
    • dizziness or fainting
    • shakiness
    • sweating
    • confusion
    • nervousness, irritability, or sudden changes in behavior or mood
    • headache
    • numbness or tingling around the mouth
    • weakness
    • pale skin
    • sudden hunger
    • clumsy or jerky movements
    • difficulty breathing
    • seizures
    • tiredness
    • vomiting

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor. Your blood pressure should be checked regularly to determine your response to nebivolol. Your doctor may ask you to check your pulse (heart rate). Ask your pharmacist or doctor to teach you how to take your pulse. If your pulse is faster or slower than it should be, call your doctor.
    Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking nebivolol.
    Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Bystolic®
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