2011501747 Health Library | Health and Wellness | Wellmont Health System
  • Midazolam

    (mid' ay zoe lam)

    IMPORTANT WARNING:

    Midazolam may cause serious or life-threatening breathing problems such as shallow, slowed, or temporarily stopped breathing. Your child should only receive this medication in a hospital or doctor's office that has the equipment that is needed to monitor his or her heart and lungs and to provide life-saving medical treatment quickly if his or her breathing slows or stops. Your child's doctor or nurse will watch your child closely after he or she receives this medication to make sure that he or she is breathing properly. Tell your child's doctor if your child has a severe infection or if he or she has or has ever had any airway or breathing problems or heart or lung disease. Tell your child's doctor and pharmacist if your child is taking any of the following medications: antidepressants; barbiturates such as secobarbital (Seconal); droperidol (Inapsine); medications for anxiety, mental illness, or seizures; narcotic medications for pain such as fentanyl (Actiq, Duragesic, Sublimaze, others), morphine (Avinza, Kadian, MS Contin, others), and meperidine (Demerol); sedatives; sleeping pills; or tranquilizers.

    WHY is this medicine prescribed?

    Midazolam is given to children before medical procedures or before anesthesia for surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. Midazolam is in a class of medications called benzodiazepines. It works by slowing activity in the brain to allow relaxation and sleep.

    HOW should this medicine be used?

    Midazolam comes as a syrup to take by mouth. It is usually given as a single dose by a doctor or nurse before a medical procedure or surgery.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your child's doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before your child receives midazolam,
    • tell your child's doctor and pharmacist if he or she is allergic to midazolam, any other medications, or cherries.
    • tell your child's doctor if your child is taking certain medications for human immunodeficiency virus (HIV) including amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), fosamprenavir (Lexiva), indinavir (Crixivan),lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus). Your child's doctor may decide not to give midazolam to your child if he or she is taking one or more of these medications.
    • tell your child's doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements your child is taking or plans to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: amiodarone (Cordarone, Pacerone); aminophylline (Truphylline); antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); certain calcium channel blockers such as diltiazem (Cartia, Cardizem, Tiazac, others) and verapamil (Calan, Isoptin, Verelan, others); cimetidine (Tagamet); clarithromycin (Biaxin); dalfopristin-quinupristin (Synercid); erythromycin (E-mycin, E.E.S.); fluvoxamine (Luvox); certain medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); methylphenidate (Concerta, Metadate, Ritalin, others); nefazodone; ranitidine (Zantac); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane). Your child's doctor may need to change the doses of your child's medications or monitor your child carefully for side effects. Many other medications may also interact with midazolam, so be sure to tell your child's doctor about all the medications your child is taking, even those that do not appear on this list.
    • tell your child's doctor what herbal products your child is taking, especially St. John's wort.
    • tell your child's doctor if your child has glaucoma. Your child's doctor may decide not to give your child midazolam.
    • tell your child's doctor if your child has or has ever had kidney or liver disease.
    • tell your child's doctor if your child is or may be pregnant, or is breast-feeding.
    • you should know that midazolam may make your child very drowsy and may affect his or her memory, thinking, and movements. Do not allow your child to ride a bicycle, drive a car, or do other activities that require him or her to be fully alert for at least 24 hours after receiving midazolam and until the effects of the medication have worn off. Watch your child carefully to be sure that he or she does not fall while walking during this time.
    • you should know that alcohol can make the side effects of midazolam worse.

    What SPECIAL DIETARY instructions should I follow?

    Do not let your child eat grapefruit or drink grapefruit juice while taking this medication.

    What SIDE EFFECTS can this medicine cause?

    Midazolam may cause side effects. Tell your child's doctor if any of these symptoms are severe or do not go away:
    • nausea
    • vomiting
    • rash
    Some side effects can be serious. If your child experiences any of these symptoms, call his or her doctor immediately:
    • agitation
    • restlessness
    • uncontrollable shaking of a part of the body
    • stiffening and jerking of the arms and legs
    • aggression
    • slow or irregular heartbeat
    Midazolam may cause other side effects. Call your child's doctor if your child has any unusual problems while taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • drowsiness
    • confusion
    • problems with balance and movement
    • slowed breathing and heartbeat
    • loss of consciousness

    What OTHER INFORMATION should I know?

    Keep all appointments with your child's doctor.
    Ask your child's pharmacist or doctor if you have any questions about midazolam.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines your child is taking, as well as many products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time your child visits a doctor or if he or she is admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Versed®
    • Also available generically

    Midazolam Injection

    (mid' ay zoe lam)

    IMPORTANT WARNING:

    Midazolam injection may cause serious or life-threatening breathing problems such as shallow, slowed, or temporarily stopped breathing that may lead to permanent brain injury or death. You should only receive this medication in a hospital or doctor's office that has the equipment that is needed to monitor your heart and lungs and to provide life-saving medical treatment quickly if your breathing slows or stops. Your doctor or nurse will watch you closely after you receive this medication to make sure that you are breathing properly. Tell your doctor if you have a severe infection or if you have or have ever had any lung, airway, or breathing problems or heart disease. Tell your doctor and pharmacist if you are taking any of the following medications: antidepressants; barbiturates such as secobarbital (Seconal); droperidol (Inapsine); medications for anxiety, mental illness, or seizures; narcotic medications for pain such as fentanyl (Actiq, Duragesic, Sublimaze, others), meperidine (Demerol),and morphine (Avinza, Kadian, MS Contin, others); sedatives; sleeping pills; or tranquilizers.

    WHY is this medicine prescribed?

    Midazolam injection is used before medical procedures and surgery to cause drowsiness, relieve anxiety, and prevent any memory of the event. It is also sometimes given as part of the anesthesia during surgery to produce a loss of consciousness. Midazolam injection is also used to cause a state of decreased consciousness in seriously ill people in intensive care units (ICU) who are breathing with the help of a machine. Midazolam injection is in a class of medications called benzodiazepines. It works by slowing activity in the brain to allow relaxation and decreased consciousness.

    HOW should this medicine be used?

    Midazolam injection comes as a solution (liquid) to be injected into a muscle or vein by a doctor or nurse in a hospital or clinic.
    If you receive midazolam injection in the ICU over a long period of time, your body may become dependent on it. Your doctor will probably decrease your dose gradually to prevent withdrawal symptoms such as seizures, uncontrollable shaking of a part of the body, hallucinations (seeing things or hearing voices that do not exist), stomach and muscle cramps, nausea, vomiting, sweating, fast heartbeat, difficulty falling asleep or staying asleep, and depression.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before receiving midazolam injection,
    • tell your doctor and pharmacist if you are allergic to midazolam or any other medications.
    • tell your doctor if you are taking certain medications for human immunodeficiency virus (HIV) including amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva, in Atripla), fosamprenavir (Lexiva), indinavir (Crixivan),lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus). Your doctor may decide not to give you midazolam injection if you are taking one or more of these medications.
    • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: aminophylline (Truphylline); certain antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); certain calcium channel blockers such as diltiazem (Cartia, Cardizem, Tiazac, others) and verapamil (Calan, Isoptin, Verelan, others); cimetidine (Tagamet); dalfopristin-quinupristin (Synercid); and erythromycin (E-mycin, E.E.S.). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with midazolam, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
    • tell your doctor if you have glaucoma (increased pressure in the eyes that may cause gradual loss of vision). Your doctor may decide not to give you midazolam injection.
    • tell your doctor if you have recently stopped drinking large amounts of alcohol or if you have or have ever had kidney or liver disease.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.
    • talk to your doctor about the risks and benefits of receiving midazolam injection if you are 65 years of age or older. Older adults should usually receive lower doses of midazolam injection because higher doses are more likely to cause serious side effects.
    • you should know that midazolam may make you very drowsy and may affect your memory, thinking, and movements. Do not drive a car or do other activities that require you to be fully alert for at least 24 hours after receiving midazolam and until the effects of the medication have worn off. If your child is receiving midazolam injection, watch him or her carefully to be sure that he or she does not fall while walking during this time.
    • you should know that alcohol can make the side effects from midazolam injection worse.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What SIDE EFFECTS can this medicine cause?

    Midazolam injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • headache
    • drowsiness
    • nausea
    • vomiting
    • hiccups
    • coughing
    • pain, redness, or hardening of the skin at the injection site
    Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
    • agitation
    • restlessness
    • uncontrollable shaking of a part of the body
    • stiffening and jerking of the arms and legs
    • aggression
    • seizures
    • uncontrollable rapid eye movements
    • hives
    • rash
    • itching
    • difficulty breathing or swallowing
    Midazolam injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • drowsiness
    • confusion
    • problems with balance and movement
    • slowed reflexes
    • slowed breathing and heartbeat
    • coma (loss of consciousness for a period of time)

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor.
    Ask your doctor or pharmacist if you have any questions about midazolam injection.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Versed®
    • Also available generically
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