• Terbutaline Injection

    (ter byoo' ta leen)

    IMPORTANT WARNING:

    Terbutaline injection is sometimes used to stop or prevent premature labor in pregnant women, however, it is not approved by the Food and Drug Administration for this purpose. Terbutaline injection should only be given to women who are in a hospital and should not be used to treat premature labor for longer than 48 to 72 hours. Terbutaline has caused serious side effects, including death, in pregnant women who took the medication for this purpose. Terbutaline has also caused serious side effects in newborns whose mothers took the medication to stop or prevent labor.

    WHY is this medicine prescribed?

    Terbutaline injection is used to treat wheezing, shortness of breath, and breathing difficulties caused by asthma, chronic bronchitis, and emphysema. Terbutaline is in a class of medications called beta agonists. It works by relaxing and opening the airways, making it easier to breathe.

    HOW should this medicine be used?

    Terbutaline injection comes as a solution (liquid) to inject under the skin. It is usually given by a doctor or nurse in a medical facility when needed to treat symptoms of asthma, chronic bronchitis, or emphysema. If the symptoms do not improve within 15-30 minutes after the first dose, another dose may be given. If the symptoms do not improve within 15-30 minutes after the second dose, a different treatment should be used.

    Are there OTHER USES for this medicine?

    Terbutaline injection is also sometimes used for a short period of time (less than 48 to 72 hours) to treat premature labor in pregnant women who are in a hospital. Talk to your doctor about the risks of using this medication for your condition.
    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before receiving terbutaline injection,
    • tell your doctor and pharmacist if you are allergic to terbutaline, any other medications, or any of the ingredients in terbutaline injection. Ask your pharmacist for a list of the ingredients.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: beta blockers such as atenolol (Tenormin), carteolol (Cartrol), labetalol (Normodyne, Trandate), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), and timolol (Blocadren); certain diuretics ('water pills'); other medications for asthma; and medications for colds, appetite control, and attention-deficit hyperactivity disorder. Also tell your doctor if you are taking any of the following medications or if you have stopped taking them in the past 2 weeks: tricyclic antidepressants including amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), maprotiline, nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil) and monoamine oxidase inhibitors (MAOIs) including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have or have ever had an irregular heartbeat, heart disease, high blood pressure, an overactive thyroid gland, diabetes, or seizures.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using terbutaline injection, call your doctor.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What SIDE EFFECTS can this medicine cause?

    Terbutaline injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • uncontrollable shaking of a part of the body
    • nervousness
    • dizziness
    • drowsiness
    • weakness
    • headache
    • nausea
    • vomiting
    • sweating
    • flushing (feeling of warmth)
    • pain at the injection site
    Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
    • increased difficulty breathing
    • tightening of the throat
    • fast, pounding, or irregular heartbeat
    • chest pain
    • seizures
    Terbutaline injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • chest pain
    • fast, pounding, or irregular heartbeat
    • dizziness or fainting
    • nervousness
    • headache
    • uncontrollable shaking of a part of the body
    • excessive tiredness
    • difficulty falling asleep or staying asleep
    • weakness
    • dry mouth
    • seizures

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor.
    Ask your pharmacist any questions you have about terbutaline injection.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Terbutaline

    (ter byoo' ta leen)

    IMPORTANT WARNING:

    Terbutaline should not be used to stop or prevent premature labor in pregnant women, especially in women who are not in a hospital. Terbutaline has caused serious side effects, including death, in pregnant women who took the medication for this purpose. Terbutaline has also caused serious side effects in newborns whose mothers took the medication to stop or prevent labor.

    WHY is this medicine prescribed?

    Terbutaline is used to prevent and treat wheezing, shortness of breath, and breathing difficulties caused by asthma, chronic bronchitis, andemphysema. Terbutaline is in a class of medications called beta agonists. It works by relaxing and opening the airways, making it easier to breathe.

    HOW should this medicine be used?

    Terbutaline comes as a tablet to take by mouth. The tablets are usually taken three times a day, once every six hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take terbutaline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
    Each dose of terbutaline should control your symptoms for at least 6 hours after you take it. If you find that your symptoms return before it is time for your next dose, that terbutaline does not control your symptoms as well as it did at the beginning of your treatment, or that your symptoms are getting worse, call your doctor. These may be signs that your condition is worsening.
    Terbutaline may control your symptoms but will not cure your condition. Continue to use terbutaline even if you feel well. Do not stop taking terbutaline without talking to your doctor.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking terbutaline,
    • tell your doctor and pharmacist if you are allergic to terbutaline, any other medications, or any of the ingredients in terbutaline tablets. Ask your pharmacist for a list of the ingredients.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: beta blockers such as atenolol (Tenormin), carteolol (Cartrol), labetalol (Normodyne, Trandate), metoprolol (Lopressor), nadolol (Corgard), propanolol (Inderal), sotalol (Betapace), and timolol (Blocadren); certain diuretics ( 'water pills'); other medications for asthma; and medications for colds, appetite control, and attention-deficit hyperactivity disorder. Also tell your doctor if you are taking any of the following medications or if you have stopped taking them in the past 2 weeks: tricyclic antidepressants including amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), maprotiline, nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil) and monoamine oxidase inhibitors (MAOIs) including isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have or have ever had an irregular heartbeat, heart disease, high blood pressure, an overactive thyroid gland, diabetes, or seizures.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking terbutaline, call your doctor.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking terbutaline.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Terbutaline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • uncontrollable shaking of a part of the body
    • nervousness
    • dizziness
    • drowsiness
    • difficulty falling asleep or staying asleep
    • weakness
    • headache
    • nausea
    • sweating
    • dry mouth
    Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
    • increased difficulty breathing
    • tightening of the throat
    • fast, pounding, or irregular heartbeat
    • chest pain
    • seizures
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].
    Terbutaline may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • chest pain
    • fast, pounding, or irregular heartbeat
    • dizziness or fainting
    • nervousness
    • headache
    • uncontrollable shaking of a part of the body
    • excessive tiredness
    • difficulty falling asleep or staying asleep
    • weakness
    • dry mouth
    • seizures

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor.
    Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Brethine®[¶]
    • Bricanyl®[¶]
    • Also available generically
    These branded products are no longer on the market and only generic alternatives are available.
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