• Loxapine

    (lox' a peen)


    Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as loxapine have an increased chance of death during treatment.
    Loxapine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking loxapine. For more information visit the FDA website: http://www.fda.gov/Drugs

    WHY is this medicine prescribed?

    Loxapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Loxapine is in a group of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.

    HOW should this medicine be used?

    Loxapine comes as a capsule to take by mouth. It is usually taken two to four times a day. Try to take loxapine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take loxapine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
    Your doctor will probably start you on a low dose of loxapine and increase your dose during the first 7 to 10 days of your treatment until your symptoms are controlled. Once your symptoms have been controlled for some time, your doctor may decrease your dose. Be sure to tell your doctor how you are feeling during your treatment with loxapine.
    Loxapine may control your symptoms but will not cure your condition. It may take several weeks or longer for you to feel the full benefit of loxapine. Continue to take loxapine even if you feel well. Do not stop taking loxapine without talking to your doctor.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking loxapine,
    • tell your doctor and pharmacist if you are allergic to loxapine or any other medications.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; antihistamines; atropine (in Motofen, in Lomotil, in Lonox); barbiturates such as pentobarbital (Nembutal), phenobarbital (Luminal), and secobarbital (Seconal); epinephrine (Epipen); ipratropium (Atrovent); lorazepam (Ativan); medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; narcotic medications for pain; sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
    • tell your doctor if you have or have ever had seizures, difficulty urinating, glaucoma (condition in which increased pressure in the eye can lead to gradual loss of vision), breast cancer, or heart disease. Also tell your doctor if you have ever had to stop taking any medication for mental illness due to severe side effects.
    • tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breast-feeding. If you become pregnant while taking loxapine, call your doctor. Loxapine may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking loxapine.
    • you should know that this medication may make you drowsy and may affect your thinking and movements. Do not drive a car or operate machinery until you know how this medication affects you.
    • ask your doctor about the safe use of alcohol during your treatment with loxapine. Alcohol can make the side effects of loxapine worse.
    • you should know that loxapine may cause dizziness, fainting, and lightheadedness, especially when you get up from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Loxapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • drowsiness
    • dizziness
    • faintness
    • weakness
    • difficulty falling asleep or staying asleep
    • blurred vision
    • dry mouth
    • increased saliva
    • nausea
    • vomiting
    • constipation
    • difficulty urinating
    • excessive thirst
    • weight gain or loss
    • agitation
    • slurred speech
    • headache
    • rash
    • itching
    • hair loss
    • flushing
    • drooping eyelids
    • puffing of the face
    • blank facial expression
    • shuffling walk
    • unusual, slowed, or uncontrollable movements of any part of the body
    • restlessness
    • numbness, burning, or tingling of the hands or feet
    • breast milk production
    • breast enlargement
    • missed menstrual periods
    • decreased sexual ability in men
    Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
    • fever
    • muscle stiffness
    • confusion
    • fast or irregular heartbeat
    • sweating
    • neck cramps
    • tightness in the throat
    • difficulty breathing or swallowing
    • tongue that sticks out of the mouth
    • fine, worm-like tongue movements
    • uncontrollable, rhythmic face, mouth, or jaw movements
    • seizures
    • decreased vision, especially in low light
    Loxapine may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • sleepiness
    • loss of consciousness
    • slowed breathing
    • slowed heartbeat
    • unusual, slowed, or uncontrollable movements of any part of the body
    • seizures

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor.
    Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Loxitane®[¶]
    • Also available generically

    Other Names

    • Oxilapine
    These branded products are no longer on the market and only generic alternatives are available.
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