• Guaifenesin

    (gwye fen' e sin)

    IMPORTANT WARNING:

    FDA Intends to Remove Some Unapproved Cough, Cold, and Allergy Drugs from the Market

    This safety alert does not apply to this medication, but only to some products which contain this medication. In addition, it is important that you know that there is not a problem with most of the products described in this medication monograph. And some drug companies may decide to seek full approval from the FDA so that they can continue marketing their products.
    On March 2, 2011, the Food and Drug Administration (FDA) issued a safety alert about certain unapproved prescription cough, cold, and allergy products containing this drug in combination with other drugs. These products are not currently approved by the FDA for safety, effectiveness, and quality. FDA asked drug companies to stop shipping most of these products for sale in the US within the next 6 months. Although some of these products have been marketed for many years, laws about what a company must prove to FDA for drug product approval have gotten tougher and increased enforcement of these laws is now taking place. The FDA took this action due to concerns about certain potential risks associated with use of these medications. These risks may include:
    • the possibility of improper use in infants and young children
    • potentially risky combinations of ingredients
    • patients receiving too much or too little of the medication because of problems with the way some ''timed-release'' products are made
    If you are concerned that the prescription cough, cold, and allergy medication you are taking is not approved by the FDA, you should talk to your doctor or pharmacist. If the medication you are taking is not approved, your doctor can prescribe another prescription medication or your doctor or pharmacist can suggest an over-the-counter (OTC) cough, cold, and allergy product for your condition. There are many safe and effective alternative approved products that can be taken instead. Your doctor probably prescribed the medicine without knowing that FDA had not approved it. This is because it has been so difficult for doctors and pharmacists to find out that these products are unapproved. For additional information:

    WHY is this medicine prescribed?

    Guaifenesin is used to relieve chest congestion . Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.

    HOW should this medicine be used?

    Guaifenesin comes as a tablet, a capsule, an extended-release (long-acting) tablet, dissolving granules, and a syrup (liquid) to take by mouth. The tablets, capsules, dissolving granules, and syrup are usually taken with or without food every 4 hours as needed. The extended-release tablet is usually taken with or without food every 12 hours. Follow the directions on the package or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take guaifenesin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
    Guaifenesin comes alone and in combination with antihistamines, cough suppressants, and decongestants. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using two or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.
    Nonprescription cough and cold combination products, including products that contain guaifenesin, can cause serious side effects or death in young children. Do not give these products to children younger than 4 years of age. If you give these products to children 4 to 11 years of age, use caution and follow the package directions carefully.
    If you are giving guaifenesin or a combination product that contains guaifenesin to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give guaifenesin products that are made for adults to children.
    Before you give a guaifenesin product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child.
    If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.
    Swallow the extended-release tablets whole with a full glass of water. Do not break, crush, or chew them.
    If you are taking the dissolving granules, empty the entire contents of the packet onto your tongue and swallow.
    If your symptoms do not improve within 7 days or if you also have a high fever, a rash, or a headache that does not go away, call your doctor.

    Are there OTHER USES for this medicine?

    This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking guaifenesin,
    • tell your doctor and pharmacist if you are allergic to guaifenesin, any other medications, or any of the ingredients in the guaifenesin product you plan to take. Check the package label for a list of the ingredients.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
    • tell your doctor if you smoke and if you have or have ever had a cough that occurs with a large amount of phlegm (mucus) or if you have or have ever had a breathing problem such as asthma, emphysema, or chronic bronchitis. If you will be taking the dissolving granules, tell your doctor if you are on a low magnesium diet or if you have kidney disease.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking guaifenesin, call your doctor.
    • if you have phenylketonuria (PKU, a inherited condition in which a special diet must be followed to prevent mental retardation), you should know that the dissolving granules may be sweetened with aspartame, a source of phenylalanine.

    What SPECIAL DIETARY instructions should I follow?

    Drink plenty of fluids while you are taking this medication.
    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    Guaifenesin is usually taken as needed. If your doctor has told you to take guaifenesin regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Guaifenesin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • headache
    • nausea
    • vomiting
    Guaifenesin may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What OTHER INFORMATION should I know?

    Ask your pharmacist any questions you have about guaifenesin.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Bidex®
    • Diabetic Tussin®
    • Ganidin NR®[§]
    • Glytuss®[¶]
    • Guaiatussin®[¶]
    • Guaifen NR®[¶]
    • Guiacough®[¶]
    • Guiatuss®
    • Halotussin®[¶]
    • Humibid E®[§]
    • Hytuss®[¶]
    • Iophen NR®
    • Lotussin®[¶]
    • Mallotuss®[¶]
    • Mastussin®[¶]
    • Miltuss EX®[¶]
    • Mucinex®
    • Mytussin®[¶]
    • Organ-I NR®[§]
    • Organidin NR®[§]
    • Phanasin®[¶]
    • Q-Tussin®
    • Ri-Tussin®[¶]
    • Robitussin®
    • Scot-Tussin®
    • Siltussin SA®
    • Tussin®
    • AccuHist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Aldex GS® (as a combination product containing Guaifenesin, Pseudoephedrine)
    • Aldex GS DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Alka-Seltzer Plus Mucus and Congestion® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Allfen DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Ambifed® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Ambifed DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Aquatab C® (as a combination product containing Carbetapentane, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Aquatab DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Betavent® (as a combination product containing Carbetapentane, Guaifenesin)[¶]
    • Biotuss® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Bitex® (as a combination product containing Codeine, Guaifenesin)[¶]
    • BP 8® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Bromhist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Bromhist PDX® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Broncholate® (as a combination product containing Ephedrine, Guaifenesin)[¶]
    • Broncopectol® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Brondil® (as a combination product containing Dyphylline, Guaifenesin)[¶]
    • Bronkaid® (as a combination product containing Ephedrine, Guaifenesin)
    • Bronkotuss® (as a combination product containing Chlorpheniramine, Ephedrine, Guaifenesin)[¶]
    • Brontex® (as a combination product containing Codeine, Guaifenesin)[¶]
    • Brontuss® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Brontuss DX® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Brontuss SF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Certuss® (as a combination product containing Chlophedianol, Guaifenesin)
    • Certuss Multilayer® (as a combination product containing Carbetapentane, Guaifenesin)[§]
    • Certuss-D® (as a combination product containing Chlophedianol, Guaifenesin, Pseudoephedrine)
    • Cheracol D® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Cheracol with Codeine® (as a combination product containing Codeine, Guaifenesin)[¶]
    • Cheratussin® (as a combination product containing Codeine, Guaifenesin)[¶]
    • Children's Mucinex Chest Congestion® (as a combination product containing Guaifenesin)
    • Children's Mucinex Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Children's Mucinex Multi-Symptom Cold® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Chlordex GP® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Codafen® (as a combination product containing Codeine, Guaifenesin)[¶]
    • Codiclear DH® (as a combination product containing Guaifenesin, Hydrocodone)[¶]
    • Coldmist DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Coldmist LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Comtrex Deep Chest Cold Non Drowsy® (as a combination product containing Acetaminophen, Guaifenesin)[¶]
    • Coricidin HBP Chest Congestion and Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Coricidin HBP Day and Night Multi-Symptom Cold® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Guaifenesin)
    • Decon E® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Decon G® (as a combination product containing Brompheniramine, Guaifenesin, Phenylephrine)[§]
    • Deconex® (as a combination product containing Guaifenesin, Phenylephrine)[¶]
    • Defen LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Despec® (as a combination product containing Guaifenesin, Phenylephrine)
    • Despec NR® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Diabetic Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Difil-G® (as a combination product containing Dyphylline, Guaifenesin)
    • Dilex-G® (as a combination product containing Dyphylline, Guaifenesin)[§]
    • Donatuss DC® (as a combination product containing Dihydrocodeine, Guaifenesin, Phenylephrine)[§]
    • Donatussin® (as a combination product containing Guaifenesin, Phenylephrine)
    • Drituss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Duratuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Dyfilin GG® (as a combination product containing Dyphylline, Guaifenesin)[¶]
    • Dyflex-G® (as a combination product containing Dyphylline, Guaifenesin)[¶]
    • Dynatuss EX® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Dyphylline GG® (as a combination product containing Dyphylline, Guaifenesin)[§]
    • Dyphysin® (as a combination product containing Dyphylline, Guaifenesin)[¶]
    • Endacof XP® (as a combination product containing Guaifenesin, Hydrocodone)[¶]
    • Endacon DM® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Entex LA® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Entex LQ® (as a combination product containing Guaifenesin, Phenylephrine)
    • Entex PSE® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Entuss® (as a combination product containing Guaifenesin, Hydrocodone)[¶]
    • Exall D® (as a combination product containing Carbetapentane, Guaifenesin, Pseudoephedrine)[§]
    • ExeClear-C® (as a combination product containing Codeine, Guaifenesin)[§]
    • Execof® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • ExeFen DMX® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • ExeFen IR® (as a combination product containing Guaifenesin, Pseudoephedrine)
    • Expectuss® (as a combination product containing Carbetapentane, Guaifenesin)[§]
    • Fenesin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Ganituss DM NR® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Genetuss 2® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Gentex LQ® (as a combination product containing Carbetapentane, Guaifenesin, Phenylephrine)[§]
    • Giltuss® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Glycotuss-DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Guaidex TR® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Methscopolamine, Pseudoephedrine)[§]
    • Guaifen DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Guiadrine DX® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Guiatex PE® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Guiatuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Guiatussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Halotussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Histacol DM® (as a combination product containing Brompheniramine, Guaifenesin, Dexchlorpheniramine, Pseudoephedrine)[§]
    • HT-Tuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Humibid CS® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Humibid DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Hycotuss® (as a combination product containing Guaifenesin, Hydrocodone)[¶]
    • Iophen C-NR® (as a combination product containing Codeine, Guaifenesin)
    • Iophen DM-NR® (as a combination product containing Dextromethorphan, Guaifenesin)
    • J-Max® (as a combination product containing Guaifenesin, Phenylephrine)
    • Kwelcof® (as a combination product containing Guaifenesin, Hydrocodone)[¶]
    • Lartus® (as a combination product containing Dextromethorphan, Guaifenesin, Phelyephrine)[§]
    • Levall® (as a combination product containing Carbetapentane, Guaifenesin, Phenylephrine)[§]
    • Liquibid D-R® (as a combination product containing Guaifenesin, Phenylephrine)
    • Liquibid PD-R® (as a combination product containing Guaifenesin, Phenylephrine)
    • Lortuss EX® (as a combination product containing Codeine, Guaifenesin, Pseudoephedrine)
    • Lotussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Lufyllin-GG® (as a combination product containing Dyphylline, Guaifenesin)[§]
    • Lusonex® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Maxiphen® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Maxi-Tuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Medent DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Medent LD® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Montephen® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Mucinex Cough for Kids® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Mucinex D® (as a combination product containing Guaifenesin, Pseudoephedrine)
    • Mucinex DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Muco Fen DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Mudrane GG® (as a combination product containing Aminophylline, Ephedrine, Guaifenesin, Phenobarbital)[¶]
    • Mytussin AC® (as a combination product containing Codeine, Guaifenesin)[¶]
    • Mytussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Naldecon DX® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Nalex® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Nariz® (as a combination product containing Guaifenesin, Phenylephrine)[¶]
    • Nasatab LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Nortuss EX® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Numonyl DX® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[¶]
    • Oratuss® (as a combination product containing Carbetapentane, Guaifenesin, Phenylephrine)[§]
    • Panfil® (as a combination product containing Dyphylline, Guaifenesin)[¶]
    • PediaCare Children's Cough and Congestion® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Pediahist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Phencarb GG® (as a combination product containing Carbetapentane, Guaifenesin, Phenylephrine)[§]
    • Phenydex® (as a combination product containing Dextromethorphan, Guaifenesin, Pyrilamine)[§]
    • Poly Hist CB® (as a combination product containing Carbetapentane, Guaifenesin)[§]
    • Poly-Tussin EX® (as a combination product containing Dihydrocodeine, Guaifenesin, Phenylephrine)[§]
    • Polyvent® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Primatene® (as a combination product containing Ephedrine, Guaifenesin)
    • Prolex DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Prolex PD® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Pulmari GP® (as a combination product containing Carbetapentane, Guaifenesin)[§]
    • Q-BID DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Q-Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Quartuss® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Quibron® (as a combination product containing Guaifenesin, Theophylline)[¶]
    • Quintex® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Respa 1st® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Respa DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Respa PE® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Respaire® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Respi Tann G® (as a combination product containing Carbetapentane, Guaifenesin)[§]
    • Robafen AC® (as a combination product containing Guaifenesin, Codeine)
    • Robitussin Cough and Chest DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Robitussin Cough and Cold CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Ru-Tuss DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Scot-Tussin DM® (as a combination product containing Chlorpheniramine, Dextromethorphan)
    • Scot-Tussin Senior® (as a combination product containing Guaifenesin, Dextromethorphan)
    • Siltussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Simuc DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Sine-Off Cough/Cold® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Sine-Off Severe Cold® (as a combination product containing Acetaminophen, Guaifenesin, Phenylephrine)
    • Sinutuss DM® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Sinuvent PE® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Sitrex® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Sudafed PE Cold/Cough® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Sudafed PE Day/Night Cold® (as a combination product containing Acetaminophen, Dextromethorphan, Diphenhydramine, Guaifenesin, Phenylephrine)
    • Sudafed PE Non-Drying Sinus® (as a combination product containing Guaifenesin, Phenylephrine)
    • Sudafed PE Triple Action® (as a combination product containing Acetaminophen, Guaifenesin, Phenylephrine)
    • Sudafed Triple Action® (as a combination product containing Acetaminophen, Guaifenesin, Pseudoephedrine)
    • Sudatex DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tenar DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tenar PSE® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Theraflu Flu and Chest Congestion® (as a combination product containing Acetaminophen, Guaifenesin)
    • Theraflu Max-D Severe Cold and Flu® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Touro CC® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Touro DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Touro LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Triaminic Chest and Nasal Congestion® (as a combination product containing Guaifenesin, Phenylephrine)
    • Trikof D® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Trispec DMX® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Trispec PSE® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Trituss® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Tusnel® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin)[§]
    • Tussafed EX® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Tussafed LA® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tussbid® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Tussi Pres® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Tussidex® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Tussin CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Tylenol Cold and Flu Severe® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Tylenol Cold Multi-Symptom Severe® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Tylenol Sinus Congestion and Pain Severe® (as a combination product containing Acetaminophen, Guaifenesin, Phenylephrine)
    • Tylenol Sinus Severe Congestion Daytime® (as a combination product containing Acetaminophen, Guaifenesin, Pseudoephedrine)
    • Vanacof DX® (as a combination product containing Chlophedianol, Guaifenesin, Pseudoephedrine)
    • Vicks DayQuil Mucus Control® (as a combination product containing Guaifenesin)
    • Vicks DayQuil Mucus Control DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Vicks Formula 44 Custom Care Chesty Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Vicks VapoSyrup Severe Congestion® (as a combination product containing Guaifenesin, Phenylephrine)
    • Visonex® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Wellbid D® (as a combination product containing Guaifenesin, Phenylephrine)[§]
    • Z-Cof DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Z-Cof LA® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Z-Dex® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Zicam Multi-Symptom Cold and Flu Daytime® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin)
    • Zodryl DEC® (as a combination product containing Codeine, Guaifenesin, Pseudoephedrine)
    • Zotex® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Also available generically
    § These products are not currently approved by the FDA for safety, effectiveness, and quality. Federal law generally requires that prescription drugs in the U.S. be shown to be both safe and effective prior to marketing. Please see the FDA website for more information on unapproved drugs ( http://www.fda.gov/AboutFDA/Transparency/Basics/ucm213030.htm) and the approval process ( http://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm054420.htm).
    These branded products are no longer on the market and only generic alternatives are available.

    Pseudoephedrine

    (soo doe e fed' rin)

    IMPORTANT WARNING:

    FDA Intends to Remove Some Unapproved Cough, Cold, and Allergy Drugs from the Market

    This safety alert does not apply to this medication, but only to some products which contain this medication. In addition, it is important that you know that there is not a problem with most of the products described in this medication monograph. And some drug companies may decide to seek full approval from the FDA so that they can continue marketing their products.
    On March 2, 2011, the Food and Drug Administration (FDA) issued a safety alert about certain unapproved prescription cough, cold, and allergy products containing this drug in combination with other drugs. These products are not currently approved by the FDA for safety, effectiveness, and quality. FDA asked drug companies to stop shipping most of these products for sale in the US within the next 6 months. Although some of these products have been marketed for many years, laws about what a company must prove to FDA for drug product approval have gotten tougher and increased enforcement of these laws is now taking place. The FDA took this action due to concerns about certain potential risks associated with use of these medications. These risks may include:
    • the possibility of improper use in infants and young children
    • potentially risky combinations of ingredients
    • patients receiving too much or too little of the medication because of problems with the way some ''timed-release'' products are made
    If you are concerned that the prescription cough, cold, and allergy medication you are taking is not approved by the FDA, you should talk to your doctor or pharmacist. If the medication you are taking is not approved, your doctor can prescribe another prescription medication or your doctor or pharmacist can suggest an over-the-counter (OTC) cough, cold, and allergy product for your condition. There are many safe and effective alternative approved products that can be taken instead. Your doctor probably prescribed the medicine without knowing that FDA had not approved it. This is because it has been so difficult for doctors and pharmacists to find out that these products are unapproved. For additional information:

    WHY is this medicine prescribed?

    Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages.

    HOW should this medicine be used?

    Pseudoephedrine comes as a regular tablet, a 12-hour extended-release (long-acting) tablet, a 24-hour extended-release tablet, and a solution (liquid) to be taken by mouth. The regular tablets and liquid are usually taken every 4 to 6 hours. The 12-hour extended-release tablets usually are taken every 12 hours, and you should not take more than two doses in a 24-hour period. The 24-hour extended-release tablets usually are taken once a day, and you should not take more than one dose in a 24-hour period. To help prevent trouble sleeping, take the last dose of the day several hours before bedtime. Follow the directions on the package label or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pseudoephedrine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or directed on the label.
    Pseudoephedrine comes alone and in combination with other medications. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using 2 or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.
    Nonprescription cough and cold combination products, including products that contain pseudoephedrine, can cause serious side effects or death in young children. Do not give other nonprescription pseudoephedrine products to children younger than 4 years of age. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully. Do not give pseudoephedrine extended-release tablets to children younger than 12 years of age.
    If you are giving pseudoephedrine or a combination product that contains pseudoephedrine to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give pseudoephedrine products that are made for adults to children.
    Before you give a pseudoephedrine product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child.
    If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.
    If your symptoms do not get better within 7 days or if you have a fever, stop taking pseudoephedrine and call your doctor.
    Swallow the extended-release tablets whole; do not break, crush, or chew them.

    Are there OTHER USES for this medicine?

    This medication is also sometimes used to prevent ear pain and blockage caused by pressure changes during air travel or underwater diving. Talk to your doctor or pharmacist for more information.
    This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking pseudoephedrine,
    • tell your doctor and pharmacist if you are allergic to pseudoephedrine, any other medications, or any of the inactive ingredients in the pseudoephedrine product you plan to take. Check the package label for a list of the ingredients.
    • do not take pseudoephedrine if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 2 weeks.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention medications for diet or appetite control, asthma, colds, or high blood pressure.
    • tell your doctor if you have or have ever had high blood pressure, glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision), diabetes, difficulty urinating (due to an enlarged prostate gland), or thyroid or heart disease. If you plan to take the 24-hour extended-release tablets, tell your doctor if you have had a narrowing or blockage of your digestive system.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pseudoephedrine, call your doctor.
    • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pseudoephedrine.

    What SPECIAL DIETARY instructions should I follow?

    Foods and drinks that contain large amounts of caffeine can make the side effects of pseudoephedrine worse.

    What should I do IF I FORGET to take a dose?

    This medication is usually taken as needed. If your doctor has told you to take pseudoephedrine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Pseudoephedrine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • restlessness
    • nausea
    • vomiting
    • weakness
    • headache
    Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
    • nervousness
    • dizziness
    • difficulty sleeping
    • stomach pain
    • difficulty breathing
    • fast, pounding, or irregular heartbeat
    Pseudoephedrine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What OTHER INFORMATION should I know?

    If you are taking the 24-hour extended-release tablets, you may notice something that looks like a tablet in your stool. This is just the empty tablet shell, and this does not mean that you did not get your complete dose of medication.
    Ask your pharmacist any questions you have about pseudoephedrine.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Afrinol®[¶]
    • Cenafed®[¶]
    • Children's Sudafed Nasal Decongestant®
    • Congestaclear®[¶]
    • Efidac®[¶]
    • Myfedrine®[¶]
    • Pseudocot®[¶]
    • Ridafed®[¶]
    • Silfedrine®
    • Sudafed 12/24 Hour®
    • Sudafed Congestion®
    • Sudodrin®[¶]
    • SudoGest®
    • Sudrine®[¶]
    • Superfed®[¶]
    • Suphedrin®
    • AccuHist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Advil Allergy Sinus® (as a combination product containing Chlorpheniramine, Ibuprofen, Pseudoephedrine)
    • Advil Cold and Sinus® (as a combination product containing Ibuprofen, Pseudoephedrine)
    • Alavert Allergy and Sinus D-12® (as a combination product containing Loratadine, Pseudoephedrine)
    • Aldex GS® (as a combination product containing Guaifenesin, Pseudoephedrine)
    • Aldex GS DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Aleve-D Sinus and Cold® (as a combination product containing Naproxen, Pseudoephedrine)
    • Allergy Relief D® (as a combination product containing Cetirizine, Pseudoephedrine)
    • Ambifed® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Ambifed DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Biodec DM® (as a combination product containing Dextromethorphan, Pseudoephedrine)[§]
    • BP 8® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Brofed® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • Bromdex® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)[§]
    • Bromfed® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • Bromfed DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Bromhist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Bromphenex DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Bromuphed® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • Bromuphed PD® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • Brotapp® (as a combination product containing Brompheniramine, Pseudoephedrine)
    • Brotapp-DM Cold and Cough® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Brovex PSB® (as a combination product containing Brompheniramine, Pseudoephedrine)
    • Brovex PSB DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Brovex SR® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • Carbofed DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)[§]
    • Certuss-D® (as a combination product containing Chlophedianol, Guaifenesin, Pseudoephedrine)
    • Cetiri-D® (as a combination product containing Cetirizine, Pseudoephedrine)
    • Children's Advil Cold® (as a combination product containing Ibuprofen, Pseudoephedrine)
    • Children's Motrin Cold® (as a combination product containing Ibuprofen, Pseudoephedrine)
    • Chlorfed A SR® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Clarinex-D® (as a combination product containing Desloratadine, Pseudoephedrine)
    • Claritin-D® (as a combination product containing Loratadine, Pseudoephedrine)
    • Coldamine® (as a combination product containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)[§]
    • Coldmist DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Coldmist LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Colfed A® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Corzall® (as a combination product containing Carbetapentane, Pseudoephedrine)[§]
    • Dallergy PSE® (as a combination product containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)[§]
    • Deconamine® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Deconomed SR® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Defen LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Dimetane DX® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Drixoral® (as a combination product containing Dexbrompheniramine, Pseudoephedrine)
    • Drymax® (as a combination product containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)[§]
    • Dynahist ER® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • EndaCof-DC® (as a combination product containing Codeine, Pseudoephedrine)
    • EndaCof-PD® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)[§]
    • Entex PSE® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Exall D® (as a combination product containing Carbetapentane, Guaifenesin, Pseudoephedrine)[§]
    • ExeFen DMX® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • ExeFen IR® (as a combination product containing Guaifenesin, Pseudoephedrine)
    • Guaidex TR® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Methscopolamine, Pseudoephedrine)[§]
    • Hexafed® (as a combination product containing Dexchlorpheniramine, Pseudoephedrine)[§]
    • Histacol DM® (as a combination product containing Brompheniramine, Guaifenesin, Dexchlorpheniramine, Pseudoephedrine)[§]
    • Histex® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Lodrane® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • LoHist-D® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • LoHist-PD® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • LoHist-PSB® (as a combination product containing Brompheniramine, Pseudoephedrine)
    • LoHist-PSB-DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Lortuss DM® (as a combination product containing Dextromethorphan, Doxylamine, Pseudoephedrine)
    • Lortuss EX® (as a combination product containing Codeine, Guaifenesin, Pseudoephedrine)
    • Lortuss LQ® (as a combination product containing Doxylamine, Pseudoephedrine)
    • Medent DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Medent LD® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Mintex® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Mucinex D® (as a combination product containing Guaifenesin, Pseudoephedrine)
    • Myphetane Dx® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)[§]
    • Nalex® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Nasatab LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Neutrahist® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Notuss-NXD® (as a combination product containing Chlorcyclizine, Codeine, Pseudoephedrine)[§]
    • Pediahist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Polyvent® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Pseudodine® (as a combination product containing Pseudoephedrine, Triprolidine)
    • Relcof PSE® (as a combination product containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)[§]
    • Respa 1st® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Respaire® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Respivent D® (as a combination product containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)[§]
    • Rezira® (as a combination product containing Hydrocodone, Pseudoephedrine)
    • Rondamine DM® (as a combination product containing Dextromethorphan, Pseudoephedrine)[§]
    • Rondec® (as a combination product containing Brompheniramine, Pseudoephedrine)[§]
    • Rondec DM® (as a combination product containing Dextromethorphan, Pseudoephedrine)[§]
    • Ru-Tuss DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Semprex-D® (as a combination product containing Acrivastine, Pseudoephedrine)
    • Suclor® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Sudafed 12 Hour Pressure/Pain® (as a combination product containing Naproxen, Pseudoephedrine)
    • Sudafed Triple Action® (as a combination product containing Acetaminophen, Guaifenesin, Pseudoephedrine)
    • Sudahist® (as a combination product containing Chlorpheniramine, Pseudoephedrine)[§]
    • Sudatex DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Sudatrate® (as a combination product containing Methscopolamine, Pseudoephedrine)[§]
    • Tekral® (as a combination product containing Diphenhydramine, Pseudoephedrine)[§]
    • Tenar DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tenar PSE® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Theraflu Max-D Severe Cold and Flu® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Touro CC® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Touro LA® (as a combination product containing Guaifenesin, Pseudoephedrine)[§]
    • Triacin® (as a combination product containing Pseudoephedrine, Triprolidine)
    • Trikof D® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Trispec PSE® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tussafed LA® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tylenol Sinus Severe Congestion Daytime® (as a combination product containing Acetaminophen, Guaifenesin, Pseudoephedrine)
    • Vanacof® (as a combination product containing Chlophedianol, Dexchlorpheniramine, Pseudoephedrine)
    • Vanacof DX® (as a combination product containing Chlophedianol, Guaifenesin, Pseudoephedrine)
    • Viravan P® (as a combination product containing Pseudoephedrine, Pyrilamine)[§]
    • Viravan PDM® (as a combination product containing Dextromethorphan, Pseudoephedrine, Pyrilamine)[§]
    • Z-Cof DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Zodryl DEC® (as a combination product containing Codeine, Guaifenesin, Pseudoephedrine)
    • Zutripro® (as a combination product containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
    • Zymine DRX® (as a combination product containing Pseudoephedrine, Triprolidine)[§]
    • Zyrtec-D® (as a combination product containing Cetirizine, Pseudoephedrine)
    • Also available generically
    § These products are not currently approved by the FDA for safety, effectiveness, and quality. Federal law generally requires that prescription drugs in the U.S. be shown to be both safe and effective prior to marketing. Please see the FDA website for more information on unapproved drugs ( http://www.fda.gov/AboutFDA/Transparency/Basics/ucm213030.htm) and the approval process ( http://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm054420.htm).
    These branded products are no longer on the market and only generic alternatives are available.

    Dextromethorphan

    (dex troe meth or' fan)

    IMPORTANT WARNING:

    FDA Intends to Remove Some Unapproved Cough, Cold, and Allergy Drugs from the Market

    This safety alert does not apply to this medication, but only to some products which contain this medication. In addition, it is important that you know that there is not a problem with most of the products described in this medication monograph. And some drug companies may decide to seek full approval from the FDA so that they can continue marketing their products.
    On March 2, 2011, the Food and Drug Administration (FDA) issued a safety alert about certain unapproved prescription cough, cold, and allergy products containing this drug in combination with other drugs. These products are not currently approved by the FDA for safety, effectiveness, and quality. FDA asked drug companies to stop shipping most of these products for sale in the US within the next 6 months. Although some of these products have been marketed for many years, laws about what a company must prove to FDA for drug product approval have gotten tougher and increased enforcement of these laws is now taking place. The FDA took this action due to concerns about certain potential risks associated with use of these medications. These risks may include:
    • the possibility of improper use in infants and young children
    • potentially risky combinations of ingredients
    • patients receiving too much or too little of the medication because of problems with the way some ''timed-release'' products are made
    If you are concerned that the prescription cough, cold, and allergy medication you are taking is not approved by the FDA, you should talk to your doctor or pharmacist. If the medication you are taking is not approved, your doctor can prescribe another prescription medication or your doctor or pharmacist can suggest an over-the-counter (OTC) cough, cold, and allergy product for your condition. There are many safe and effective alternative approved products that can be taken instead. Your doctor probably prescribed the medicine without knowing that FDA had not approved it. This is because it has been so difficult for doctors and pharmacists to find out that these products are unapproved. For additional information:

    WHY is this medicine prescribed?

    Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing.

    HOW should this medicine be used?

    Dextromethorphan comes as a liquid-filled capsule, a chewable tablet, a dissolving strip, a solution (liquid), an extended-release (long-acting) suspension (liquid), and a lozenge to take by mouth. It is usually taken every 4 to 12 hours as needed. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
    Dextromethorphan should only be used according to the label or package directions. Do not take more than the recommended amount of dextromethorphan in a 24-hour period. Refer to the package or prescription label to determine the amount contained in each dose. Taking dextromethorphan in large amounts can cause serious side effects or death.
    Dextromethorphan comes alone and in combination with antihistamines, cough suppressants, and decongestants. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using 2 or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.
    Nonprescription cough and cold combination products, including products that contain dextromethorphan, can cause serious side effects or death in young children. Do not give these products to children younger than 4 years of age. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully.
    If you are giving dextromethorphan or a combination product that contains dextromethorphan to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give dextromethorphan products that are made for adults to children.
    Before you give a dextromethorphan product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child's age on the chart. Ask the child's doctor if you don't know how much medication to give the child.
    If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.
    If you are using the dissolving strips, place them on your tongue and swallow after they melt.
    If you are taking the chewable tablets you can allow them to melt in your mouth or you can chew them before swallowing.
    If you are taking the extended-release suspension, shake the bottle well before each use to mix the medication evenly.
    If you are taking the lozenges, allow them to slowly melt in your mouth.
    Stop taking dextromethorphan and call your doctor if your cough does not get better within 7 days, if your cough goes away and comes back, or if your cough occurs with a fever, rash, or headache.

    Are there OTHER USES for this medicine?

    This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking dextromethorphan,
    • tell your doctor and pharmacist if you are allergic to dextromethorphan, any other medications, or any of the ingredients in the product you plan to take. Check the package label for a list of the ingredients.
    • do not take dextromethorphan if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 2 weeks.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
    • tell your doctor if you smoke, if you have a cough that occurs with a large amount of phlegm (mucus), or if you have or have ever had breathing problems such as asthma, emphysema, or chronic bronchitis.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking dextromethorphan, call your doctor.
    • if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that some brands of chewable tablets that contain dextromethorphan may be sweetened with aspartame, a source of phenylalanine.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    Dextromethorphan is usually taken as needed. If your doctor has told you to take dextromethorphan regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Dextromethorphan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • dizziness
    • lightheadedness
    • drowsiness
    • nervousness
    • restlessness
    • nausea
    • vomiting
    • stomach pain
    If you experience any of the following symptoms, call your doctor immediately:
    • rash
    Dextromethorphan may cause other side effects. Call your doctor if you experience any unusual problems while you are taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
    Symptoms of overdose may include:
    • nausea
    • vomiting
    • drowsiness
    • dizziness
    • unsteadiness
    • changes in vision
    • difficulty breathing
    • fast heartbeat
    • hallucinating (seeing things or hearing voices that do not exist)
    • seizures
    • coma (loss of consciousness for a period of time)

    What OTHER INFORMATION should I know?

    Ask your pharmacist any questions you have about dextromethorphan.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Babee Cof®[¶]
    • Benylin®
    • Children's Robitussin Cough Long-Acting®
    • Dexalone®[¶]
    • Diabetuss®[¶]
    • Pertussin ES®[¶]
    • Scot-Tussin Diabetes CF®
    • Silphen DM®
    • Vicks DayQuil Cough®
    • Vicks Formula 44 Custom Care Dry Cough®
    • Zicam Cough MAX®
    • AccuHist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • AccuHist PDX® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
    • Alahist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
    • Albatussin NN® (as a combination product containing Dextromethorphan, Phenylephrine, Potassium Guaiacolsulfonate, Pyrilamine)[§]
    • Aldex DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Aldex GS DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Alka-Seltzer Plus Cold and Cough Formula® (as a combination product containing Aspirin, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Alka-Seltzer Plus Day and Night Cold Formulas® (as a combination product containing Aspirin, Dextromethorphan, Phenylephrine)
    • Alka-Seltzer Plus Day Non-Drowsy Cold Formula® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
    • Alka-Seltzer Plus Flu Formula® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Alka-Seltzer Plus Mucus and Congestion® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Alka-Seltzer Plus Night Cold Formula® (as a combination product containing Aspirin, Dextromethorphan, Doxylamine, Phenylephrine)
    • Allanhist PDX® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[¶]
    • Allfen DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Ambifed DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Amerituss AD® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[¶]
    • Aquatab C® (as a combination product containing Carbetapentane, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Aquatab DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Balacall DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)[¶]
    • Biodec DM® (as a combination product containing Dextromethorphan, Pseudoephedrine)[§]
    • Biotuss® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • BP 8® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • BPM PE DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)[§]
    • Bromdex® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)[§]
    • Bromfed DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Bromhist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Bromhist PDX® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Bromphenex DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Bromtuss DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)[§]
    • Broncopectol® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Bronkids® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Brontuss® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Brontuss DX® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Brontuss SF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Brotapp PE-DM Cough and Cold® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
    • Brotapp-DM Cold and Cough® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Brovex PEB DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
    • Brovex PSB DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • C Phen DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Carbofed DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)[§]
    • Cardec DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Centergy DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Ceron DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Cerose DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[¶]
    • Cheracol D® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Children's Dimetapp Cold and Cough® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
    • Children's Dimetapp Long Acting Cough Plus Cold® (as a combination product containing Chlorpheniramine, Dextromethorphan)
    • Children's Dimetapp Multisymptom Cold and Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Children's Mucinex Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Children's Mucinex Multi-Symptom Cold® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Children's Mucinex Stuffy Nose and Cold® (as a combination product containing Guaifenesin, Phenylephrine)
    • Children's Robitussin Cough and Cold CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Children's Robitussin Cough and Cold CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Children's Robitussin Cough and Cold Long-Acting® (as a combination product containing Chlorpheniramine, Dextromethorphan)
    • Children's Sudafed PE Cold and Cough® (as a combination product containing Dextromethorphan, Phenylephrine)
    • Chlordex GP® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Codal-DM Syrup® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[¶]
    • Codimal DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[¶]
    • Coldmist DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Comtrex Cold and Cough Day/Night® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Comtrex Cold and Cough Non-Drowsy® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
    • Corfen DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Coricidin HBP Chest Congestion and Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Coricidin HBP Cough and Cold® (as a combination product containing Chlorpheniramine, Dextromethorphan)
    • Coricidin HBP Day and Night Multi-Symptom Cold® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Guaifenesin)
    • Coricidin HBP Maximum Strength Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan)
    • Coricidin HBP Nighttime Multi-Symptom Cold® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
    • Coryza DM® (as a combination product containing Dexchlorpheniramine, Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Despec NR® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Diabetic Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Dimaphen DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)[¶]
    • Dimetane DX® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Donatussin DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Drituss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Drixoral Cough/Sore Throat® (as a combination product containing Acetaminophen, Dextromethorphan)[¶]
    • Duratuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Duravent-DPB® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)[§]
    • Dynatuss EX® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Endacon DM® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Execof® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • ExeFen DMX® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Fenesin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Ganituss DM NR® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Genetuss 2® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Giltuss® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Guaidex TR® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Methscopolamine, Pseudoephedrine)[§]
    • Guiadrine DX® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Guiatuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Halotussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Histadec DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[¶]
    • HT-Tuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Humibid CS® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Humibid DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Iophen DM-NR® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Lartus® (as a combination product containing Dextromethorphan, Guaifenesin, Phelyephrine)[§]
    • Lohist-DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)[§]
    • LoHist-PEB-DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
    • LoHist-PSB-DM® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
    • Lortuss DM® (as a combination product containing Dextromethorphan, Doxylamine, Pseudoephedrine)
    • Maxichlor® (as a combination product containing Chlorpheniramine, Dextromethorphan)[¶]
    • Maxiphen ADT® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Maxi-Tuss DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Medent DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Mintuss DR® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Mucinex Cough for Kids® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Mucinex DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Muco Fen DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • MyHist DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Myphetane Dx® (as a combination product containing Brompheniramine, Dextromethorphan, Pseudoephedrine)[§]
    • Mytussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Naldecon DX® (as a combination product containing Dextromethorphan, Guaifenesin)[¶]
    • Nasohist DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Neo DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • NoHist-DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Norel DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Nortuss EX® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • PediaCare Children's Cough and Congestion® (as a combination product containing Dextromethorphan, Guaifenesin)
    • PediaCare Children's Fever Reducer Plus Cough and Runny Nose® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan)
    • PediaCare Children's Fever Reducer Plus Cough and Sore Throat® (as a combination product containing Acetaminophen, Dextromethorphan)
    • PediaCare Children's Fever Reducer Plus Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • PediaCare Children's Fever Reducer Plus Multi-Symptom Cold® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • PediaCare Children's Multi-Symptom Cold® (as a combination product containing Dextromethorphan, Phenylephrine)
    • Pediahist DM® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Phenydex® (as a combination product containing Dextromethorphan, Guaifenesin, Pyrilamine)[§]
    • Poly Hist DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Polytan DM® (as a combination product containing Dexbrompheniramine, Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Poly-Tussin DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Prolex DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Prometh DM® (as a combination product containing Dextromethorphan, Promethazine)
    • Promethazine DM® (as a combination product containing Dextromethorphan, Promethazine)
    • Pyril DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Q-BID DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Q-Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Quartuss® (as a combination product containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Quartuss DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • RemeHist DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • RemeTussin DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Respa DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Resperal® (as a combination product containing Dexchlorpheniramine, Dextromethorphan, Phenylephrine, Pyrilamine)[¶]
    • Robitussin Cough and Chest DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Robitussin Cough and Cold CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Robitussin Cough and Cold Long-Acting® (as a combination product containing Chlorpheniramine, Dextromethorphan)
    • Robitussin Night Time Cough, Cold, and Flu® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Rondamine DM® (as a combination product containing Dextromethorphan, Pseudoephedrine)[§]
    • Rondec DM® (as a combination product containing Dextromethorphan, Pseudoephedrine)[§]
    • Ru-Tuss DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Scot-Tussin DM® (as a combination product containing Chlorpheniramine, Dextromethorphan)
    • Scot-Tussin Senior® (as a combination product containing Guaifenesin, Dextromethorphan)
    • Sildec PE DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Siltussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Simuc DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Sinutuss DM® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Sonahist DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Statuss DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Sudafed PE Cold/Cough® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Sudafed PE Day/Night Cold® (as a combination product containing Acetaminophen, Dextromethorphan, Diphenhydramine, Guaifenesin, Phenylephrine)
    • Sudatex DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tenar DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Theraflu Cold and Cough® (as a combination product containing Dextromethorphan, Pheniramine, Phenylephrine)
    • Theraflu Daytime Severe Cold and Cough® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
    • Theraflu Max-D Severe Cold and Flu® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
    • Touro CC® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Touro DM® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Triaminic Cough and Sore Throat® (as a combination product containing Acetaminophen, Dextromethorphan)
    • Triaminic Day Time Cold and Cough® (as a combination product containing Dextromethorphan, Phenylephrine)
    • Triaminic Long Acting Cough® (as a combination product containing Dextromethorphan)
    • Triaminic Multi-Symptom Fever® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan)
    • Trikof D® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Triplex DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Trispec DMX® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Trispec PSE® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Trital DM® (as a combination product containing Chlorpheniramine, Dextromethorphan, Phenylephrine)[§]
    • Trituss® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Tusdec DM® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)[§]
    • Tusnel® (as a combination product containing Brompheniramine, Dextromethorphan, Guaifenesin)[§]
    • Tussafed EX® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Tussafed LA® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Tussi Pres® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Tussidex® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Tussin CF® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Tussin DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Tylenol Cold and Cough Daytime® (as a combination product containing Acetaminophen, Dextromethorphan)
    • Tylenol Cold and Cough Nighttime® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
    • Tylenol Cold and Flu Severe® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Tylenol Cold Multi-Symptom Nighttime® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylephrine)
    • Tylenol Cold Multi-Symptom Severe® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine)
    • Vicks Children's NyQuil Cold and Flu® (as a combination product containing Chlorpheniramine, Dextromethorphan)
    • Vicks DayQuil Cold and Flu Relief® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
    • Vicks DayQuil Cold and Flu Symptom Relief Plus Vitamin C® (as a combination product containing Acetaminophen, Dextromethorphan, Phenylephrine)
    • Vicks DayQuil Mucus Control DM® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Vicks Formula 44 Custom Care Chesty Cough® (as a combination product containing Dextromethorphan, Guaifenesin)
    • Vicks Formula 44 Custom Care Congestion® (as a combination product containing Dextromethorphan, Phenylephrine)
    • Vicks Formula 44 Custom Care Cough and Cold PM® (as a combination product containing Acetaminophen, Chlorpheniramine, Dextromethorphan)
    • Vicks NyQuil Cold and Flu Relief® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
    • Vicks NyQuil Cold and Flu Symptom Relief Plus Vitamin C® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
    • Vicks NyQuil Cough® (as a combination product containing Dextromethorphan, Doxylamine)
    • Viratan DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Viravan DM® (as a combination product containing Dextromethorphan, Phenylephrine, Pyrilamine)[§]
    • Viravan PDM® (as a combination product containing Dextromethorphan, Pseudoephedrine, Pyrilamine)[§]
    • Y-Cof DMX® (as a combination product containing Brompheniramine, Dextromethorphan, Phenylephrine)
    • Z-Cof DM® (as a combination product containing Dextromethorphan, Guaifenesin, Pseudoephedrine)[§]
    • Z-Cof LA® (as a combination product containing Dextromethorphan, Guaifenesin)[§]
    • Z-Dex® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)
    • Zicam Multi-Symptom Cold and Flu Daytime® (as a combination product containing Acetaminophen, Dextromethorphan, Guaifenesin)
    • Zicam Multi-Symptom Cold and Flu Nighttime® (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
    • Zotex® (as a combination product containing Dextromethorphan, Guaifenesin, Phenylephrine)[§]
    • Also available generically

    Other Names

    • DM
    § These products are not currently approved by the FDA for safety, effectiveness, and quality. Federal law generally requires that prescription drugs in the U.S. be shown to be both safe and effective prior to marketing. Please see the FDA website for more information on unapproved drugs ( http://www.fda.gov/AboutFDA/Transparency/Basics/ucm213030.htm) and the approval process ( http://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm054420.htm).
    These branded products are no longer on the market and only generic alternatives are available.
  • Join WellZones today.

    Make a Change For LifeLearn more

    Wellmont LiveWell is creating a new tradition of wellness in the mountains by providing individuals with tools and encouragement to live healthier lifestyles.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease early and prevent heart attacks with HeartSHAPE® - a painless, non-invasive test that takes pictures of your heart to scan for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.


  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.