• Famotidine

    (fa moe' ti deen)

    WHY is this medicine prescribed?

    Prescription famotidine is used to treat ulcers (sores on the lining of the stomach or small intestine); gastroesophageal reflux disease (GERD, a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus [tube that connects the mouth and stomach]); and conditions where the stomach produces too much acid, such as Zollinger-Ellison syndrome (tumors in the pancreas or small intestine that cause increased production of stomach acid). Over-the-counter famotidine is used to prevent and treat heartburn due to acid indigestion and sour stomach caused by eating or drinking certain foods or drinks. Famotidine is in a class of medications called H2 blockers. It works by decreasing the amount of acid made in the stomach.

    HOW should this medicine be used?

    Prescription famotidine comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken once daily at bedtime or two to four times a day. Over-the-counter famotidine comes as a tablet, a chewable tablet, and a capsule to take by mouth. It is usually taken once or twice a day. To prevent symptoms, it is taken 15 to 60 minutes before eating foods or drinking drinks that may cause heartburn. Follow the directions on your prescription or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take famotidine exactly as directed. Do not take more or less of it or take it more often or for a longer time than prescribed by your doctor.
    Shake the liquid well for 5 to 10 seconds before each use to mix the medicine evenly.
    Swallow the tablets and capsules with a full glass of water.
    Thoroughly chew the chewable tablets before swallowing them. Swallow the chewed tablet with a full glass of water.
    Do not take more than two tablets, capsules, or chewable tablets of over-the-counter famotidine in 24 hours and do not take over-the-counter famotidine for longer than 2 weeks unless your doctor tells you that you should. If symptoms of heartburn, acid indigestion, or sour stomach last longer than 2 weeks, stop taking over-the-counter famotidine and call your doctor.

    Are there OTHER USES for this medicine?

    This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

    What SPECIAL PRECAUTIONS should I follow?

    Before taking famotidine,
    • tell your doctor and pharmacist if you are allergic to famotidine, cimetidine (Tagamet), nizatidine (Axid), ranitidine (Zantac), or any other medications.
    • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any other medications for heartburn. Do not take over-the-counter famotidine with any other prescription or nonprescription medications for heartburn unless a doctor tells you that you should.
    • tell your doctor if you have phenylketonuria (PKU, an inborn disease in which mental retardation develops if a specific diet is not followed), and if you have or have ever had trouble swallowing or kidney disease.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking famotidine, call your doctor.

    What SPECIAL DIETARY instructions should I follow?

    Unless your doctor tells you otherwise, continue your normal diet.

    What should I do IF I FORGET to take a dose?

    If you forget a dose of prescription famotidine, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
    Over-the-counter famotidine is usually taken as needed. If your doctor has told you to take over-the-counter famotidine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

    What SIDE EFFECTS can this medicine cause?

    Famotidine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
    • headache
    • dizziness
    • constipation
    • diarrhea
    • fussiness (in babies who take famotidine)
    Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them call your doctor immediately:
    • hives
    • skin rash
    • itching
    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
    • hoarseness
    • difficulty breathing or swallowing
    Famotidine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch ] or by phone [1-800-332-1088].

    What should I know about STORAGE and DISPOSAL of this medication?

    Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not allow the liquid to freeze. Throw away any medication that is outdated or no longer needed, and throw away unused famotidine liquid after 30 days. Talk to your pharmacist about the proper disposal of your medication.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What OTHER INFORMATION should I know?

    Keep all appointments with your doctor.
    Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.
    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Brand Names

    • Pepcid®
    • Pepcid® AC
    • Pepcid® RPD
    • Pepcid® Complete (as a combination product containing Calcium Carbonate, Famotidine, Magnesium Hydroxide)

    Famotidine Injection

    (fa moe' ti deen)

    WHY is this medicine prescribed?

    Your doctor has ordered famotidine to decrease the amount of acid your stomach makes. It is used to treat and prevent ulcers and to treat other conditions in which the stomach makes too much acid. The drug will be either added to an intravenous fluid that will drip through a needle or catheter placed in your vein for at least 15 minutes, once or twice a day, or administered by constant infusion over 24 hours. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
    Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how you respond to the medication.

    What SPECIAL PRECAUTIONS should I follow?

    Before administering famotidine,
    • tell your doctor and pharmacist if you are allergic to famotidine, cimetidine (Tagamet), nizatidine (Axid), ranitidine (Zantac), or any other drugs.
    • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.
    • tell your doctor if you have or have ever had kidney or liver disease.
    • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking famotidine, call your doctor.

    HOW should this medicine be used?

    Before you administer famotidine, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.
    It is important that you use your medication exactly as directed. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.

    What SIDE EFFECTS can this medicine cause?

    Famotidine may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away:
    • headache
    • dizziness
    • constipation
    • diarrhea

    What should I know about STORAGE and DISPOSAL of this medication?

    • Your health care provider probably will give you a several-day supply of famotidine at a time. If you are receiving famotidine intravenously (in your vein), you probably will be told to store it in the refrigerator or freezer.
    • Take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.
    • If you are told to store additional famotidine in the freezer, always move a 24-hour supply to the refrigerator for the next day's use.
    • Do not refreeze medications.
    Store your medication only as directed. Make sure you understand what you need to store your medication properly.
    Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.

    What should I do in case of OVERDOSE?

    In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

    What are the SIGNS OF AN INFECTION?

    If you are receiving famotidine in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:
    • tenderness
    • warmth
    • irritation
    • drainage
    • redness
    • swelling
    • pain

    Brand Names

    • Pepcid® I.V.
    • Pepcid® Premixed in Iso-osmotic Sodium Chloride Injection
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