• Symptoms of Sickle Cell Disease

    Symptoms of sickle cell disease may be noticed as soon as 4 months of age, or it may go undetected until later in the baby’s first year of life.
    Oxygen deprivation is a result of blood vessels that are blocked by the misshapen red blood cells of sickle cell anemia. Periods of acute oxygen deprivation cause severely painful episodes called pain crises. The location of the pain and the types of symptoms depend on what tissues or organs of the body have been deprived of oxygen.
    Symptoms of sickle cell disease include:
    • Fever
    • Swollen hands and feet
    • Pain in:
      • Chest
      • Abdomen
      • Arms
      • Legs
      • Joints
      • Bones
      Enlarged organs, including:
      • Heart
      • Liver
      • Spleen
    • Increased risk of infection, especially pneumonia
    • Symptoms of anemia, including:
      • Severe fatigue
      • Headache
      • Lightheadedness
      • Shortness of breath
    • Yellowish tone to the whites of the eyes and the skin—jaundice
    • Episodes of sickle cell crisis, including:
      • Severe chest pain
      • Shortness of breath
      • Severe abdominal pain
      • Severe bone pain
      • Nausea
      • Fever
      • In males, painful, prolonged erections of the penis which may result in impotence
    Other medical conditions that can result from sickle cell disease include:
    • Leg sores
    • Gum disease
    • Damage to the retina of the eye, resulting in vision loss
    • Enlargement of the heart due to chronic anemia
    • Heart attack
    • Heart failure
    • Kidney infections
    • Kidney damage and eventual failure
    • Bone infections or infarctions
    • Gallbladder disease
    • Spleen damage and destruction, resulting in an increased risk of certain infections
    • Stroke
    • Abnormal bone growth
    • Delayed puberty
    • Learning and behavior problems in children who have had severe, chronic oxygen deprivation of the brain
    • Aplastic crisis or red cell aplasia
    Sickle cell crisis can be provoked by certain triggers, including:
    • Smoking
    • Exercise
    • Travel to high altitudes
    • Drops in oxygen or changes in air pressure that can occur during airplane travel
    • Fever
    • Infection
    • Dehydration


    Sickle cell disease. Kids Health—Nemours Foundation website. Available at: http://kidshealth.org/en/parents/sickle-cell-anemia.html. Updated September 2012. Accessed July 1, 2013.

    Sickle cell disease in adults and adolescents. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T902929/Sickle-cell-disease-in-adults-and-adolescents. Updated October 4, 2016. Accessed October 5, 2016.

    Sickle cell disease in infants and children. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T902928/Sickle-cell-disease-in-infants-and-children. Updated September 20, 2016. Accessed October 5, 2016.

    What are the signs and symptoms of sickle cell disease? National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/sca/signs. Updated August 2, 2016. Accessed December 13, 2016.

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