• Risk Factors for Type 1 Diabetes

    A risk factor is something that increases your likelihood of getting a disease or condition. It is possible to develop type 1 diabetes with or without the risk factors listed below. There are no known definite risk factors. However, the more risk factors you have, the greater your likelihood of developing type 1 diabetes. The main risk factors include the following:

    Family History

    If you have a parent, brother, or sister with type 1 diabetes, you (or your child) are at greater risk of having it, too. Scientists continue to believe that genetic factors play a role in the development of type 1 diabetes, but which genes is unclear.

    Autoimmune Conditions

    Type 1 diabetes is an autoimmune disease, caused by the body's immune system attacking the insulin-producing cells of the pancreas. You may be at a greater risk of developing type 1 diabetes if you have another condition that affects the immune system, such as:

    Ethnic Background

    You are at an increased risk of type 1 diabetes if your ethnicity is:
    • Northern European
    • Mediterranean
    • African American
    • Hispanic

    Other Risk Factors

    Other factors that may increase your child's risk of type 1 diabetes include:
    • Cystic fibrosis
    • Bottle-feeding or short duration of breastfeeding
    • High birth weight
    • Obesity during childhood
    • Mothers age at childbirth (over 35 years)

    References

    Diabetes causes. National Institute of Diabetes & Digestive & Kidney Diseases website. Available at: http://diabetes.niddk.nih.gov/dm/pubs/causes/index.aspx . Accessed December 31, 2012.

    Diabetes type 1. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us . Updated December 28, 2012. Accessed December 31, 2012.

    Schatz D, Krischer J, Horne G, et al. Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives. J Clin Invest. 1994;93:2403-2407.

    TRIGR study: a new trial investigates environmental triggers in type 1 diabetes [press release]. Juvenile Diabetes Research Foundation International website. Available at: http://www.jdrf.org . August 7, 2002. Accessed December 31, 2012.

    Type 1 diabetes. American Diabetes Association website. Available at: http://www.diabetes.org/diabetes-basics/type-1/?loc=DropDownDB-type1 . Accessed December 31, 2012.

    3/12/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Cardwell CR, Stene LC, Joner G, et al. Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data. Diabetologia. 2010 Jan 10. [Epub ahead of print]

    3/12/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Cardwell CR, Stene LC, Joner G, et al. Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies. Diabetes. 2010;59(2):486-494.

    4/1/2011 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Verbeeten KC, Elks CE, Daneman D, Ong KK. Association between childhood obesity and subsequent Type 1 diabetes: a systematic review and meta-analysis. Diabet Med. 2011;28(1):10-18.

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