• Beta-blockers

    Coenzyme Q 10 (CoQ 10 ) —Supplementation Possibly Helpful Chromium —Possible Helpful Interaction Coleus forskohlii —Theoretical Interaction
    Beta-blockers are used for hypertension as well as for a variety of heart conditions.
    Drugs that fall into this family include
    • Acebutolol hydrochloride (Sectral)
    • Atenolol (Tenormin)
    • Alprenolol
    • Betaxolol hydrochloride (Kerlone)
    • Bisoprolol fumarate (Zebeta)
    • Carteolol (Cartrol)
    • Carvedilol (Coreg)
    • Esmolol hydrochloride (Brevibloc)
    • Labetalol hydrochloride (Normodyne, Trandate)
    • Metoprolol (Lopressor, Toprol XL)
    • Nadolol (Corgard)
    • Penbutolol (Levatol)
    • Pindolol (Visken)
    • Propranolol hydrochloride (Betachron E-R, Inderal, Inderal LA)
    • Sotalol (Betapace)
    • Timolol maleate (Blocadren)
    • and others
    Coenzyme Q 10 (CoQ 10 )
    There is some evidence that beta-blockers (specifically propranolol, metoprolol, and alprenolol) might impair the body's ability to utilize the substance coenzyme Q 10 (CoQ 10 ). 1,2 This is particularly worrisome, because CoQ 10 appears to play a significant role in normal heart function. 3 Depletion of CoQ 10 might be responsible for some of the side effects of beta-blockers. In one study, CoQ 10 supplements reduced side effects caused by the beta-blocker propranolol. 4 The beta-blocker timolol may interfere with CoQ 10 production to a lesser extent than other beta-blockers.
    Chromium
    Beta-blockers have been known to reduce levels of HDL ("good") cholesterol. According to one study, chromium supplementation can offset this adverse effect. 5
    Coleus forskohlii
    The herb Coleus forskohlii relaxes blood vessels and might have unpredictable effects on blood pressure if combined with beta-blockers.

    References

    1 Kishi H, et al. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q 10 -enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol. 1975;12:533-540.

    2 Kishi T, et al. Bioenergetics in clinical medicine. XV. Inhibition of coenzyme Q 10 -enzymes by clinically used adrenergic blockers of beta receptors. Res Commun Chem Pathol Pharmacol. 1977;17:157-164.

    3 Folkers K. Basic chemical research on coenzyme Q 10 and integrated clinical research on therapy of diseases. As cited in: Lenaz G, ed. Coenzyme Q. New York, NY: John Wiley and Sons; 1985.

    4 Hamada M, Kazatain Y, Ochi T, et al. Correlation between serum CoQ 10 level and myocardial contractility in hypertensive patients. In: Biomedical and Clinical Aspects of Coenzyme Q, Vol 4. Amsterdam: Elsevier; 1984: 263-270.

    5 Roeback JR, et al. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers. A randomized, controlled trial. Ann Intern Med . 1991;115:917-924.

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