• Calcium Channel Blockers

    Calcium and Vitamin D —Possible Decreased Action of Drug Ginkgo Biloba —Possible Decreased Action of Drug Naringen (a Citrus Bioflavonoid)—May Necessitate Reduction of Drug Dosage
    Calcium channel–blockers are used to treat hypertension , angina , heart arrhythmias , and other heart-related conditions.
    Examples of drugs in this family include:
    • Amlodipine (Norvasc)
    • Bepridil hydrochloride (Vascor)
    • Diltiazem (Cardizem, Cardizem CD, Cardizem SR, Dilacor XR, Tiamate, Tiazac)
    • Felodipine (Plendil)
    • Isradipine (DynaCirc, DynaCirc CR)
    • Nicardipine hydrochloride (Cardene, Cardene SR)
    • Nifedipine (Procardia, Procardia XL, Adalat, Adalat CC)
    • Nimodipine (Nimotop)
    • Nisoldipine (Sular)
    • Verapamil (Calan, Calan SR, Covera-HS, Isoptin, Isoptin SR, Verelan)
    CalciumVitamin D
    Taking calcium and vitamin D supplements might interfere with some of the effects of calcium channel-blockers. 1-7
    Ginkgo Biloba
    According to a study in rats, ginkgo extract may cause the body to metabolize some calcium channel blockers more rapidly, thereby decreasing their effects. 8
    Citrus Bioflavonoid
    Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug. 9 This may necessitate a reduction in drug dosage.

    References

    1 Bar-Or D and Gasiel Y. Calcium and calciferol antagonise effect of verapamil in atrial fibrillation. Br Med J (Clin Res Ed) . 1981;282:1585-1586.

    2 Hariman RJ, Mangiardi LM, McAllister RG Jr, et al. Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses. Circulation . 1971;59:797-804.

    3 Guadagnino V, Greengart A, Hollander G, et al. Treatment of severe left ventricular dysfunction with calcium chloride in patients receiving verapamil. J Clin Pharmacol. 1987;27:407-409.

    4 Salerno DM, Anderson B, Sharkey PJ, et al. Intravenous verapamil for treatment of multifocal atrial tachycardia with and without calcium pretreatment. Ann Intern Med. 1987;107:623-628.

    5 Luscher TF, Noll G, Sturmer T, et al. Calcium gluconate in severe verapamil intoxication. N Engl J Med. 1994;330:718-720.

    6 Orr GM, Bodansky HJ, Dymond DS, et al. Fatal verapamil overdose. Lancet. 1982;2:1218-1219.

    7 Kuhn M and Schriger DL. Low-dose calcium pretreatment to prevent verapamil-induced hypotension. Am Heart J. 1992;124:231-232.

    8 Shinozuka K, Umegaki K, Kubota Y, et al. Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci. 2002;70:2783-2792.

    9 Yeum CH, Choi JS. Effect of naringin pretreatment on bioavailability of verapamil in rabbits. Arch Pharm Res. 2006;29:102-107.

    Revision Information

  • Join WellZones today.

    Make a Change For LifeLearn more

    Wellmont LiveWell is creating a new tradition of wellness in the mountains by providing individuals with tools and encouragement to live healthier lifestyles.

  • HeartSHAPE Spotlight

    HeartSHAPE® Test Learn more

    Fight heart disease early and prevent heart attacks with HeartSHAPE® - a painless, non-invasive test that takes pictures of your heart to scan for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.


  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.