• Allergic Bronchopulmonary Aspergillosis (ABPA)

    Definition

    Allergic bronchopulmonary aspergillosis (ABPA) is an allergic lung disorder. It is related to the fungus Aspergillus fumigatus (AF). Aspergillosis can also occur as:
    • A lung infection that can spread to other parts of the body (more common in patients with suppressed immune systems)
    • A fungal growth ( aspergilloma ) in a lung cavity that has healed from a previous lung disease or infection

    Causes

    ABPA is caused by an allergic reaction to inhaled AF. AF is a common fungus. It grows and flourishes in decaying vegetation, soil, certain foods, dust, and water. The allergic reaction worsens respiratory symptoms in people with asthma or cystic fibrosis . The inhaled AF colonizes mucus in the lungs, causing:
    • Sensitization to AF
    • Recurring allergic inflammation of the lungs
    • Packing of the alveoli (tiny air sacs in the lungs) with eosinophils (a type of white blood cell involved in certain allergic reactions and infections with parasites)
    Healthy Alveoli
    Alveoli
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    Risk Factors

    A risk factor is something that increases your chances of getting a disease or condition. Risk factors for ABPA include:

    Symptoms

    Symptoms of ABPA are usually those of progressive asthma. These include:
    • Shortness of breath
    • Wheezing
    • Weakness, malaise
    • Unintended weight loss
    • Chest pain
    As ABPA progresses, other symptoms may occur, including:
    • Production of thick, brownish, and/or bloody sputum
    • Low-grade fever
    In severe, long-term cases, ABPA can cause:
    • Bronchiectasis—widening of areas of the bronchus, usually caused by inflammation
    • Scarring of lungs

    Diagnosis

    The doctor will ask about your symptoms and medical history, and perform a physical exam. Tests may include:
    • Chest x-ray —a test that uses radiation to take a picture of structures inside the body, in this case the lungs
    • Sputum tests—to check sputum for:
      • Presence of AF
      • High levels of eosinophils
      Blood tests to detect:
      • High levels of eosinophils
      • Antibodies suggesting an allergic reaction to AF
    • Skin prick tests—to check for allergic sensitivity by placing small amounts of AF in the skin
    • Biopsy of lung or sinus tissue
    • Pulmonary function tests (PFTs) —used to monitor breathing capacity of the lungs
    Since ABPA can appear quite similar to non-ABPA induced asthma, it is often difficult to determine to what extent ABPA is contributing to your symptoms. Therefore, ABPA is typically diagnosed after several repeat tests for ABPA are positive over a number of months or years.

    Treatment

    The goals of treatment include:
    • Suppressing the allergic reaction to AF
    • Minimizing lung inflammation
    • Preventing AF from colonizing the lungs
    ABPA is usually treated with:
    • Prednisone (an oral corticosteroid medication)
    • Antifungal drugs

    Prevention

    Avoiding exposure to AF is the best way to prevent ABPA. However, this is difficult, because AF is so prevalent in the environment. Guidelines to help prevent exposure to AF include:
      Avoiding areas with:
      • Decaying vegetation
      • Standing water
    • Keeping your home as dust-free as possible
    • Remaining in air-filtered, air-conditioned environments whenever possible
    Measures to avoid symptoms and prevent permanent lung damage caused by ABPA include:
    • Ongoing testing and monitoring of ABPA
    • Early and continuing medical treatment for the disease

    RESOURCES

    American Lung Association http://www.lungusa.org

    Centers for Disease Control and Prevention (CDC) http://www.cdc.gov

    National Institute of Diabetes & Digestive & Kidney Diseases http://www.niddk.nih.gov

    CANADIAN RESOURCES

    The Canadian Lung Association http://www.lung.ca

    Health Canada http://www.hc-sc.gc.ca/index-eng.php

    References

    Ferri FF. Ferri’s Clinical Advisor 2007. 9th ed. St. Louis, MO: Mosby, 2007.

    Mayo Clinic and Foundation for Medical Education and Research website. Available at: http://www.mayo.edu/ .

    The Merck Manual of Medical Information . 2nd ed. Simon and Schuster, Inc; 2004.

    National Institute of Diabetes & Digestive & Kidney Diseases website. Available at: http://www.niddk.nih.gov .

    Wark PA, Gibson PG, Wilson AJ. Azoles for allergic bronchopulmonary aspergillosis associated with asthma. Cochrane Database Syst Rev 2004; (3): CD001108.

    Revision Information

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