• Henoch-Schonlein Purpura

    (Anaphylactoid Purpura; HSP; Vascular Purpura)


    Henoch-Schonlein purpura (HSP) is inflammation of the blood vessels in the skin and other body organs. When it involves the skin, it causes a telltale rash. The rash looks like bruising or small dots in the skin, referred to as purpura.


    HSP is caused by an abnormal reaction of the immune system. Normally, the immune system marks and attacks foreign items like viruses and bacteria. However, with HSP, the immune system attacks the blood vessels. It is not clear why the immune system attacks the body.
    The change in the immune system may be triggered by:
    • Bacterial or viral infections
    • Certain medications
    • Recent exposure to certain vaccines
    • Infection by insect bites
    HSP occurs most often after a respiratory infection. HSP is not contagious.

    Risk Factors

    HSP is most common in children aged 2 to 11 years old, but it can occur at any age. Factors that increase your risk of HSP include:
    • Recent upper respiratory illness, such as a cold
    • Recent exposure to vaccines, chemicals, cold weather, or insect bites


    Symptoms may last for 4 to 6 weeks and may include:
      Skin rash:
      • Reddish-purple spots that can be felt and are not itchy
      • Often appears on the buttocks or legs, may appear on the elbows
      • Red spots of various sizes
      • Bruising, usually below the waist
    • Pain in the joints, especially knees and ankles
    • Abdominal pain
    • Blood in the urine
    • Swelling of the ankles
    • Swelling of the scrotum in males
    • Fever
    • Blood in the stool
    • Vomiting


    You will be asked your symptoms and medical history. A physical exam will be done.
    Your bodily fluids, tissues, and waste may be tested. This can be done with:
    • Blood tests
    • Urinalysis
    • Stool sample
    • Skin biopsy from an area of the rash
    Skin Biopsy
    Skin proceedure
    Copyright © Nucleus Medical Media, Inc.


    HSP usually gets better on its own. Your doctor may prescribe medications if symptoms or complications are causing problems. Medications may include:
    • Nonsteroidal anti-inflammatory drugs (NSAIDs)—to lessen joint pain and arthritis
    • Steroid medication—for significant abdominal pain, joint pain, or kidney disease
    • Antibiotics—to treat bacterial infection
    • Immune system suppressants when you have symptoms of severe kidney disease


    There are no guidelines to prevent HSP. Relapse occurs in about half of all cases.
    It is important to make sure that you have long-term, follow-up visits with your doctor to be sure that kidney disease doesn't develop.


    American Autoimmune Related Diseases Association http://www.aarda.org

    Family Doctor—American Academy of Family Physicians http://www.familydoctor.org


    Caring for Kids http://www.caringforkids.cps.ca

    College of Family Physicians of Canada http://www.cfpc.ca


    Dillon MJ. Henoch-Schonlein purpura (treatment and outcome). Cleve Clin J Med. 2002;69(Suppl 2):SII121-SII123.

    Henoch-Schonlein purpura. National Institute of Diabetes and Digestive and Kidney Disease website. Updated September 7, 2012. Available at: http://familydoctor.org/familydoctor/en/diseases-conditions/henoch-schonlein-purpura.html. Updated March 2014. Accessed June 30, 2015.

    Henoch-Schonlein purpura. National Institute of Health Office of Rare Disease Research website. Available at: http://rarediseases.info.nih.gov/GARD/Condition/8204/HenochSchonlein%5Fpurpura.aspx/Print. Accessed June 30, 2015.

    Kraft D, McKee D, et al. Henoch-Schonlein purpura: a review. Am Fam Physician. 1998 Aug 1;58(2):405-408. Available at: http://www.aafp.org/afp/1998/0801/p405.html. Accessed June 30, 2015.

    Ronkainen J, Koskimies O, et al. Early prednisone therapy in Henoch-Schonlein purpura: a randomized, double-blind, placebo-controlled trial. J Pediatr. 2006;149:241-247.

    Saulsbury FT. Epidemiology of Henoch-Schonlein purpura. Cleve Clin J Med. 2002;69(Suppl 2):SII87-SII89.

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