24202 Health Library | Health and Wellness | Wellmont Health System
  • Vitamin B2: Riboflavin

    IMAGEVitamin B2, also called riboflavin, is a water-soluble vitamin. Water-soluble vitamins are stored in the body in very limited amounts and are excreted through the urine. Therefore, it is a good idea to have them in your daily diet. Vitamin B2 is a component of two enzymes: flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are important in energy production.


    Riboflavin’s functions include:
    • Assisting in energy production
    • Helping to synthesize normal fatty acids and amino acids
    • Helping the nervous system to function efficiently
    • Aiding in cellular growth
    • Assisting in the metabolism of certain other vitamins

    Recommended Intake

    Age Group (in years) Recommended Dietary Allowance
    Females Males
    1-3 0.5 milligrams (mg) 0.5 mg
    4-8 0.6 mg 0.6 mg
    9-13 0.9 mg 0.9 mg
    14-18 1.0 mg 1.3 mg
    19+ 1.1 mg 1.3 mg
    Pregnancy 1.4 mg n/a
    Lactation 1.6 mg n/a

    Riboflavin Deficiency

    Riboflavin deficiency occurs as part of multiple nutrient deficiency states. Since riboflavin occurs in a wide variety of foods, deficiency symptoms are rare. Symptoms have been reported when daily riboflavin intake falls below 0.6 milligrams (mg). Symptoms of riboflavin deficiency include:
    • Cracks in the corner of the mouth (cheilosis)
    • Inflammation of the mucous membranes of the mouth
    • Sore or inflamed tongue (glossitis)
    • Reddening of the eyes
    • Eyes that tire easily, burn, itch, or are sensitive to light
    • Unusual skin inflammation (dermatitis) characterized by simultaneous dryness and greasy scaling

    Riboflavin Toxicity

    Riboflavin is relatively nontoxic. Although no adverse effects have been associated with high intakes of riboflavin from food or supplements, the potential may exist. Therefore, caution may be warranted with excessive amounts of riboflavin.

    Major Food Sources

    Food Serving size Riboflavin content
    Beef, cooked 3 ounces 0.16 milligrams (mg)
    Broccoli, cooked ½ cup 0.1 mg
    Spinach, cooked ½ cup 0.21 mg
    Milk, skim 1 cup 0.34 mg
    Egg 1 large 0.27 mg
    Whole grain bread 1 slice 0.06 mg

    Health Implications

    Populations at Risk for Riboflavin Deficiency

    The following populations may be at risk for riboflavin deficiency and may require a supplement:
    • People who consume excessive amounts of alcohol
    • People with other nutrient deficiencies
    • People with anorexia nervosa

    Prevention of Cataracts

    Evidence that links riboflavin to the prevention of cataracts is unclear. Two large studies showed decreases in cataract rates in people over 65 years taking multivitamins, minerals, riboflavin, and riboflavin with niacin. Although the studies showed decreased risk of cataracts, the mixing of the vitamins made it difficult to tell which supplement caused the benefits.

    Treatment of Migraine Headaches

    Talk to your doctor about using riboflavin supplements if you have migraine headaches. In some adults, 400 mg per day may prevent migraines or reduce the number of migraine attacks.

    Tips for Increasing Your Intake

    To help increase your intake of riboflavin, include some dairy products in your daily diet. Milk, yogurt, and cheese are all good sources of riboflavin. Here are some other examples of foods with riboflavin:
    • Eggs
    • Almonds
    • Leafy green vegetables
    • Milk
    • Enriched cereal
    • Meats
    Riboflavin is rapidly destroyed with exposure to sunlight. Therefore, foods containing riboflavin are best stored in a pantry, in bins, and, when perishable, in the refrigerator.


    Academy of Nutrition and Dietetics http://www.eatright.org

    United States Department of Agriculture http://www.usda.gov


    Dietitians of Canada http://www.dietitians.ca

    Health Canada Food and Nutrition http://www.hc-sc.gc.ca/fn-an/index-eng.php


    DiDonato S, Geller, C, Peluchetti D, et al. Normalization of short-chain acylcoenzyme A dehydrogenase after riboflavin treatment in a girl with multiple acylcoenzyme A dehydrogenase-deficient myopathy. Ann Neurol. 1989;25:479-484.

    Migraine prophylaxis in adults. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. UpdatedNovember 19, 2012. Accessed February 7, 2013

    Riboflavin. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated May 16, 2011. Accessed February 7, 2013.

    Riboflavin deficiency. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated January 20, 2011. Accessed February 7, 2013

    Riboflavin. The Linus Pauling Institute website. Available at: http://lpi.oregonstate.edu/infocenter/vitamins/riboflavin/. Updated June 2007. Accessed February 7, 2013.

    Sperduto RD, Hu TS, Milton RC, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol. 1993;111(9):1246-1253.

    Vitamin B2. EBSCO Natural and Alternative Treatments website. Available at: http://www.ebscohost.com/healthlibrary. Updated July 25, 2012. Accessed February 7, 2013.

    Revision Information

  • Join WellZones today.

    Make a Change For LifeLearn more

    Wellmont LiveWell is creating a new tradition of wellness in the mountains by providing individuals with tools and encouragement to live healthier lifestyles.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease early and prevent heart attacks with HeartSHAPE® - a painless, non-invasive test that takes pictures of your heart to scan for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.

  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.