• Licorice Root: Not Candy, but an Herbal Remedy

    licorice Mention the word “licorice,” and most people think of the chewy black candy that they have been eating since they were kids. But licorice is also a potent herb that has been used since ancient times for medicinal purposes.
    Licorice root comes from a purple and white flowering perennial that originated in the Mediterranean region and central and southwest Asia. Traditionally, it has been boiled to extract its sweetness, and has been used in making licorice candy. But licorice root, by itself or in compounds with other herbs, has many medicinal uses.
    Licorice root contains glycyrrhizin, a substance that can cause fluid retention, increased blood pressure, and loss of potassium, when taken in large amounts, or in moderate amounts for two weeks or more. To prevent this effect, some manufacturers remove glycyrrhizin from the licorice root, to produce a licorice-related product called deglycyrrhizinated licorice, or DGL.

    Proposed Uses of Licorice

    Gastric Ulcers and Stomach Irritation —Weak evidence suggests that DGL might help protect the stomach from the irritation and ulcers caused by nonsteroidal anti-inflammatory drugs.
    Mouth Sores—DGL might help relieve the discomfort of canker sores in the mouth, although there have not been any studies on this subject.
    Eczema, Psoriasis, and Herpes—A topical licorice cream (often mixed with chamomile extract) is sometimes used to treat various skin conditions, such as eczema, psoriasis, and herpes, but there is little evidence for its effectiveness in treating eczema.

    Dosage and Safety Issues

    For ulcer treatment, the standard dose of DGL is 2-4 380 mg tablets taken before meals and at bedtime. For mouth pain, the tablets can be slowly dissolved in the mouth.
    The standard dose of whole licorice is 5-15 grams per day. However, you should not use doses this high for more than a few weeks. Excessive use of licorice (not DGL) may increase blood pressure and cause fluid retention, headache, and loss of potassium.
    A maximum adult dose of 0.3 grams of licorice root per day has been recommended by experts for long-term use. Larger doses should only be taken under the supervision of your doctor.
    Licorice is also available in a liquid form.
    Whole licorice reduces testosterone in men, and therefore may adversely affect fertility or libido. Licorice use should be avoided by women who are pregnant or nursing, or who have had breast cancer.
    When taken with thiazide diuretic medicine, licorice may increase potassium loss. Sensitivity to digitalis glycosides may occur with loss of potassium. Licorice should not be taken with the following medications:
    • Cardiac glycosides (such as digoxin)
    • Diuretics
    • Steroids
    • Any potassium-depleting drugs
    • Antihypertnesive medicines
    If you are considering taking licorice root or DGL, talk to your doctor first to rule out potential drug interactions or other concerns.


    National Center for Complementary and Alternative MedicineNational Institutes of Health http://www.nccam.nih.gov/

    Office of Dietary SupplementsNational Institutes of Health http://ods.od.nih.gov


    Canadian Pharmacists Association www.pharmacists.ca/

    Health Canada http://www.hc-sc.gc.ca/


    Licorice. EBSCO Natural and Alternative Treatments website. Available at: http://www.ebscohost.com/healthLibrary/. Updated July 2012. Accessed August 30, 2012.

    Licorice root. National Center for Complementary and Alternative Medicine website. Available at: http://nccam.nih.gov/health/licoriceroot. Updated July 2010. Accessed August 30, 2012.

    Revision Information

  • LiveWell personal health survey

    How healthy are you really? Find out – free.Learn more

    It's time to stop guessing. If you want to make some changes but just aren't sure how, the free personal health survey from LiveWell is a great place to start.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease and prevent heart attacks. HeartSHAPE® is a painless, non-invasive test that checks pictures of your heart for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.

  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.