• Peripheral Artery Disease

    (PAD; Peripheral Vascular Disease; PVD; Arteriosclerosis Obliterans)


    Peripheral artery disease (PAD) is disease of any blood vessel that is not part of the heart or brain. PAD is caused by deposits of fatty material in arteries of the legs. Since arteries carry oxygen-rich blood to the cells of the body, a reduction in blood flow can cause organ failure.


    PAD is usually caused by a gradual buildup of plaque called atherosclerosis that happens within the arteries. Other causes include blood clots or embolisms, congenital heart disease, and inflammation of the blood vessels called vasculitis.
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    PAD can be hereditary. You also may get PAD if you are overweight or obese , or have hypertension , diabetes , or high cholesterol . Unhealthy lifestyle choices such as smoking, eating a high-fat diet, and not getting enough exercise lead to PAD.

    Risk Factors

    PAD is more common in men and in people over 50 years of age. Other factors that increase your chance of developing PAD include:
    • Family history of PAD
    • Diabetes
    • Smoking
    • High blood pressure or family history of high blood pressure
    • Stroke or family history of stroke
    • High cholesterol or family history of high cholesterol


    Symptoms of PAD are related to the organ or part of the body deprived of blood. This includes:
    • Pain, fatigue, aching, tightness, weakness, cramping or tingling in the leg(s) brought on by exercise that goes away when resting
    • Numbness and pain of the legs or feet at rest
    • Cold hands, legs, or feet
    • Loss of hair on the legs and/or feet
    • Paleness or blueness of the legs
    • Weak or absent pulse in the leg
    • Sores, ulcer, or infection of the feet and legs that heal slowly
    • Erectile dysfunction
    • Swelling in lower extremities
    • Muscle atrophy


    You will be asked about your symptoms and medical history. A physical exam will be done.
    During the exam, your doctor may:
    • Check the strength of the pulse in the leg arteries
    • Listen for a whooshing sound in a leg artery or the abdomen using a stethoscope
    • Check blood pressure at various points in the leg and compare it to the normal arm blood pressure
    • Conduct a treadmill test
    Your bodily fluids may be tested. This can be done with blood tests.
    Images help evaluate blood vessels and surrounding structures. This can be done with:
    Your heart activity may need to be tested. This can be done with an electrocardiogram (EKG).


    Early treatment can slow or stop the disease. Talk with your doctor about the best treatment plan for you. Treatment options include the following:

    Lifestyle Changes

    • Smoking cessation
    • Diabetes control
    • Blood pressure control
    • Increased physical activity—such as a walking program
    • Weight loss , if overweight
    • Low-saturated fat, low-cholesterol diet
    • Foot care —very important for people with diabetes:
      • Shoes that fit properly
      • Proper treatment of all foot injuries—healing is slowed when circulation is poor, so the risk of infection is higher


    The following medications may be prescribed:
    • Blood thinners to reduce blood clots
    • Pain medication
    • Statins to lower cholesterol
    • Vasodilators to widen arteries

    Invasive Procedures

    Procedures may include:
    • Balloon angioplasty —a balloon is inflated in the artery to stretch it
    • Stent implant—a wire mesh tube is placed in the artery; the stent expands and stays in place, keeping the artery open
    • Laser treatment
    • Atherectomy —a tube called a catheter is used to remove plaque inside a blood vessel


    Surgery to open up narrowed arteries is performed in severe cases:
    • Endarterectomy —the lining of the artery is removed, along with plaque build up
    • Bypass surgery—a vein from another part of the body or a synthetic graft replaces the vessel


    General guidelines to prevent PAD include lifestyle changes, smoking cessation, and adhering to any treatment plans for other health conditions.


    Family Doctor—American Academy of Family Physicians http://familydoctor.org

    Vascular Cures http://www.vdf.org


    Canadian Society for Vascular Surgery http://canadianvascular.ca

    Heart and Stroke Foundation of Canada http://www.heartandstroke.ca


    About peripheral artery disease (PAD). American Heart Association website. Available at: http://www.heart.org/HEARTORG/Conditions/More/PeripheralArteryDisease/About-Peripheral-Artery-Disease-PAD%5FUCM%5F301301%5FArticle.jsp. Updated September 15, 2014. Accessed March 12, 2015.

    American College of Cardiology and American Heart Association 2005 Practice Guidelines for the management of patients with peripheral arterial disease. Circulation. 2006;113:e463-654.

    Gey DC, Lesho EP, Manngold J. Management of Peripheral Arterial Disease. Am Fam Physician. 2004;69:525-532.

    Lumsden AB, Rice TW. Medical management of peripheral arterial disease: a therapeutic algorithm. J Endovasc Ther. 2006;13(suppl 2)II19-29.

    Mahmud E, Cavendish JJ, Salami A. Current treatment of peripheral arterial disease: role of percutaneous interventional therapies. J Am Coll Cardiol. 2007;50:473-490.

    Peripheral arterial disease. Am Fam Physician. 2004 Feb 1;69(3):533. Available at: http://www.aafp.org/afp/2004/0201/p533.html. Accessed March 12, 2015.

    Peripheral arterial disease and claudication. American Academy of Family Physicians Family Doctor website. Available at: http://familydoctor.org/familydoctor/en/diseases-conditions/peripheral-arterial-disease-and-claudication.html. Updated April 2014. Accessed March 12, 2015.

    Regensteiner JG, Stewart KJ. Established and evolving medical therapies for claudication in patients with peripheral arterial disease. Nat Clin Pract Cardiovasc Med. 2006;3: 604-610.

    11/18/2011 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Rooke TW, Hirsch AT, Misra S, et al. 2011 ACCF/AHA focused update of the guideline for the management of patients with peripheral artery disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124(18):2020-2045.

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