42388 Health Library | Health and Wellness | Wellmont Health System
  • Can Supplements Reduce Your Risk of Alzheimer’s Disease?

    Alzheimer's and antioxidantsAlzheimer’s disease (AD), the most common form of dementia, is a progressive, degenerative disorder of the brain that slowly impairs the ability to carry out daily activities.
    Since there are only a few medicines available to slow the progress of Alzheimer's disease, many companies are promoting the use of certain supplements to prevent and treat memory problems. Scientists are investigating the effects of these supplements, but for the most part, there is little to no evidence to support their claims. There is no supplement that has survived rigorous scientific evaluation to prove that it is consistently helpful in fighting Alzheimer’s disease.

    Supplements Studied to Stop or Slow the Progression of Alzheimer’s Disease

    There are several different types of supplements that have been studied to see if they improve mental function and reduce the risk of Alzheimer’s disease.

    Antioxidant Vitamins

    An excess of free radicals (also known as oxidants) may contribute to the development of Alzheimer’s disease. Antioxidants theoretically may protect against Alzheimer’s disease by limiting the buildup of toxic amyloid protein. Diets rich in foods containing antioxidant vitamins, such as E, C have been associated with a reduced risk of Alzheimer’s, but the supplement forms of these vitamins have essentially not shown the same association. Also one randomized trial failed to show that vitamin E supplementation prevented Alzeimer's disease. A meta-analysis noted an increase risk of death (due to all causes) in patients taking high doses of vitamin E. Based on the evidence so far, it does not appear that supplements are useful for the prevention of Alzeimer's disease.


    Gingko biloba, thought to help deliver oxygen to the brain by improving blood flow to capillaries, is the most widely used herb to improve cognitive function. However, overall the data thus far is inconclusive. Some studies have found some benefit in improving cognitive function in patients with dementia while others have not.
    Huperzine A, an extract from a club moss, may hold promise for people with Alzheimer’s disease by inhibiting the enzyme that breaks down the neurotransmitter acetylcholine (which carries information in the brain). There is some evidence in animal studies that it may have benefit. It also may have some benefit for patients who already have Alzeimer's disease. However, there is no indication that it can stave off memory loss in healthy people.
    Evidence is also mixed for vinpocetine, a chemical derived from vincamine (found in the leaves of the periwinkle plant). Vinpocetine is thought to enhance memory and mental function by improving circulation in the brain and helping the brain to utilize oxygen more efficiently. More research is needed in this area.

    Other Essential Nutrients

    There are a number of other essential nutrients that are also purported to improve cognitive function. These include:
    Carnitine, a derivative of the amino acid lysine, plays an important role in energy production. Several small trials have suggested that it can modestly slow cognitive decline in patients with AD. Overall, literature reviews suggested that it may only be mildly helpful at best for Alzheimer's disease.
    Phosphatidyl serine and choline are both involved in the structure and maintenance of cell membranes. Phosphatidyl serine has been shown to be mildly effective in the early stages of Alzheimer’s disease. Clinical trials of choline alfoscerate have also shown some promise.
    It has been suggested that a dietary deficiency of omega-3 and omega-6 (essential) fatty acids could be a risk factor for Alzheimer's disease. Evidence appears to be mixed. One review of three studies found that omega-3 fish oil supplements did not improve cognitive function in healthy adults over 60 years old. In contrast, three observational studies found that eating fish two or more times a week reduced risk of dementia and Alzheimer's disease compared to those who did not eat fish. From these studies, it appears that evidence supports eating fish, but not taking pills with these fatty acids in them.

    Are Supplements Safe?

    Buyers should beware that products that are natural are not necessarily safe or good for you. Remember that a healthy diet will likely provide you with adequate vitamins and minerals.

    Are Supplements Worth it?

    Clearly, the market for memory enhancers is huge. As the population ages, interest in ways to slow or stop the progression of Alzheimer’s disease will only continue to grow. Unfortunately, since further research is needed, it may be years before the benefits and risks of supplements are fully established. Moreover, supplements are expensive.
    Patients and families of patients should talk with their doctors before taking any supplements or over-the-counter medicines.
    In the meantime, consider that by exercising, eating right, and using your mind—reading books, playing games, learning a new language—you will improve your chances of preserving mental acuity. It may not be as simple as popping a pill, but the gains are worth it.


    Alzheimer’s Disease Education and Referral Center http://www.alzheimers.org/

    National Alzheimer’s Association http://www.alz.org/


    Alzheimer Society http://www.alzheimer.ca/en

    Health Canada http://www.hc-sc.gc.ca/index-eng.php/


    Alternative treatments Alzheimer's Association website. Available at: http://www.alz.org/alzheimers%5Fdisease%5Falternative%5Ftreatments.asp#top . Accessed December 19, 2012.

    Alzheimer disease. DynaMed website. Available at: http://www.ebscohost.com/dynamed/what.php. Updated November 21, 2012. Accessed December 19, 2012.

    Antioxidant Supplements for Health: An Introduction. National Center for Complementary and Alternative Medicine website. Available at: http://nccam.nih.gov/health/antioxidants/introduction.htm#top. Updated October 2011. Accessed December 19, 2012.

    Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano). 1993;5:123-133.

    Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, Witteman JC, Breteler MM. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA . 2002;287:3223-3229.

    Haag M. Essential fatty acids and the brain. Can J Psychiatry . 2003;48:195-203.

    Luchsinger JA, Tang M-X, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol . 2003;60:203-208.

    Miller ER, Pastor-Barruso R, Dalal D, et al. Meta-analysis: high dose vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46.

    Morris MC, Evans DA, Bienias JL, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA . 2002;287:3230-3237.

    Morris MS. Homocysteine and Alzheimer’s disease. Lancet Neurol . 2003;2:425-428.

    Oken BS, Storzbach DM, Kaye JA. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol . 1998;55:1409-1415.

    Pettegrew JW, Klunk WE, Panchalingam K, Kanfer JN, McClure RJ. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging . 1995;16:1-4.

    Solomon PR, Adams F, Silver A, Zimmer J, DeVeaux R. Ginkgo for memory enhancement: a randomized controlled trial. JAMA . 2002;288:835-840.

    Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology . 1991;41:1726-1732.

    Thal LJ, Carta A, Clarke WR, Ferris SH, Friedland RP, Petersen RC, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology . 1996;47:705-711.

    Youdim KA, Martin A, Joseph JA. Essential fatty acids and the brain: possible health implications. Int J Dev Neurosci . 2000;18:383-399.

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