498332 Health Library | Health and Wellness | Wellmont Health System
  • Heparin-Induced Thrombocytopenia

    (HIT; Heparin-Induced Low Blood Platelet Count)


    Platelets are a special type of blood cell. They help form clots so that you do not bleed too much. Heparin is a blood-thinning medication that decreases clotting.
    Thrombocytopenia means low blood platelet count. Heparin-induced thrombocytopenia is low blood platelet count caused by heparin. This condition can lead to a lot of bleeding. In some cases, it can also develop into excessive blood clotting. About 1%-2% of patients taking heparin may develop this condition.
    This can become a serious condition. It requires care from your doctor.
    Clot Formation
    blood clot platelet
    Copyright © Nucleus Medical Media, Inc.


    This type of thrombocytopenia is caused by taking heparin.

    Risk Factors

    Taking heparin is a risk factor for developing this condition. You may be taking heparin if you have had:
    • Certain heart, lung, or blood vessel conditions
    • Surgery such as heart or orthopedic surgery
    • Kidney dialysis and blood transfusions
    You may also be taking it if you are bedridden. Tell your doctor if you are taking heparin.


    If you have any of these symptoms, do not assume it is due to this condition. These symptoms may be caused by other conditions. Tell your doctor if you have any of these:
      • Excessive bleeding from cuts
      • Bleeding from your gums or nose
      • Superficial bleeding on the skin (looks like reddish/purple spots, often on the legs)
      • Blood in urine or stool
      • Heavy menstrual flow
      • Excessive bleeding during surgery
    • Pain or swelling in the legs
    • Chest pain
    • Difficulty breathing
    • Anxiety
    • Sweating
    • Rapid, irregular heartbeat
    Also let your doctor know if you have past blood tests showing a low blood platelet count.


    Your doctor will ask about your symptoms and medical history. A physical exam will be done.
    Tests may include the following:
    • Complete blood count (CBC) —a routine blood test that shows your platelet count
    • Other special blood tests, such as a heparin-induced platelet aggregation test
    • Ultrasound of limbs or other areas to detect a clot


    Talk with your doctor about the best plan for you. Treatment options include the following:
    • Stopping the use of heparin
    • Anticoagulating drugs—to reduce the risk of blood clots:
      • Danaparoid
      • Refludan ( lepirudin )
      • Argatroban
      • Arixtra ( fondaparinux)
      • Angiomax (bivalirudin)
    • Vitamin K Antagonists Therapy (VKA)— Vitamin K given once your platelet count has recovered
    • Blood transfusion —for severe bleeding, to replace lost blood


    To help reduce your chance of getting heparin-induced thrombocytopenia, discuss with your doctor the following:
    • Avoiding heparin use
    • Taking anticoagulants, such as Argatroban or Angiomax (bivalirudin)


    American Academy of Family Physicians http://www.aafp.org/

    American Heart Association http://www.americanheart.org/


    Canadian Cardiovascular Society http://www.ccs.ca/home/index%5Fe.aspx

    Heart and Stroke Foundation of Canada http://ww2.heartandstroke.ca/

    Thrombosis Interest Group of Canada http://www.tigc.org/


    Arepally G, Ortel T. Heparin-induced thrombocytopenia. N Engl J Med . 2006. 355;8: 809-17. Available at: http://enotes.tripod.com/thrombocytopenia%5Fheparin2006.pdf . Accessed May 26, 2009.

    Heparin-induced thrombocytopenia. EBSCO Dynamed website. Available at: http://www.ebscohost.com/dynamed/what.php . Updated November 3, 2008. Accessed May 26, 2009.

    Mayo Clinic. Heparin. Mayo Clinic website. Available at: http://www.mayoclinic.com/health/drug-information/DR601931 . Accessed May 26, 2009.

    Thrombocytopenia (low platelet count). Mayo Clinic website. Available at: http://www.mayoclinic.com/health/thrombocytopenia/DS00691/DSECTION=causes . Accessed May 26, 2009.

    Revision Information

  • Join WellZones today.

    Make a Change For LifeLearn more

    Wellmont LiveWell is creating a new tradition of wellness in the mountains by providing individuals with tools and encouragement to live healthier lifestyles.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease early and prevent heart attacks with HeartSHAPE® - a painless, non-invasive test that takes pictures of your heart to scan for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.

  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.