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  • Stevens-Johnson Syndrome



    Stevens-Johnson Syndrome (SJS) is a severe illness associated with fever and skin problems including rash, blisters, and ulcers. Although it can affect skin all over the body, a trademark of SJS are problems of the skin inside the mouth, nose, and eyes.
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    SJS is caused by an overreaction of the immune system to certain medications. It is not certain what causes the overreaction but it may be linked to genetic factors.

    Risk Factors

    Medications that are most often associated with SJS include:
    • Sulfonamides
    • Aminopenicillins
    • Quinolones
    • Cephalosporins
    • Tetracyclines
    • Imidazole antifungals
    • Aromatic anticonvulsants
    Other factors that may increase your risk of SJS include:
    • Diseases that decrease your immunity like HIV and systemic lupus erythematosus
    • Certain genes
    • Radiation therapy and taking anti-seizure medication to treat a brain tumor
    • Certain infections such as
      • Herpes
      • Influenza
      • Diphtheria
      • Typhoid
      • Hepatitis


    SJS symptoms progress over time. Early symptoms may include:
    • Fever
    • Sore throat
    • Cough
    • Burning eyes
    After several days, the following symptoms may occur:
    • A red or purple rash that spreads
    • Swelling of the face and tongue
    • Skin pain
    • Blisters on the skin and the skin inside the mouth, nose, and eyes
    • Shedding of the skin


    Your doctor will ask about your symptoms and medical history. A physical exam will be done. This will often result in a diagnosis.
    A sample of skin may be tested. This can be done with a biopsy.


    Talk with your doctor about the best treatment plan for you. You may be referred to a specialist for treatment depending on your symptoms.
    Treatment options include:


    Your doctor may advise you to stop taking medications that may be causing the condition.
    If not related to your symptoms, you may be given:
    • Pain medication to reduce discomfort
    • Antihistamines to reduce itching
    • Antibiotics to treat an infection caused by bacteria
    • Antiviral medications to treat an infection caused by viruses
    • Topical steroids to reduce swelling
    • IV immunoglobulin (IVIG)

    Fluid Replacement

    You may be given IV fluids at the hospital to replace lost fluids.

    Skin Treatments

    Treatments for the skin may include:
    • Applying cool, wet compresses to blisters
    • Removing dead skin
    • Wound care


    To help reduce your chance of getting SJS, avoid taking the medications that cause SJS to occur.


    Johns Hopkins Medicine http://www.hopkinsmedicine.org

    Shriners Hospitals for Children http://www.shrinershospitalsforchildren.org


    Canadian Dermatology Association http://www.dermatology.ca

    Health Canada http://www.hc-sc.gc.ca


    Stevens-Johnson syndrome. Johns Hopkins Medicine website. Available at: http://www.hopkinsmedicine.org/wilmer/conditions/stevens-johnson.html. Accessed October 3, 2013.

    Stevens-Johnson syndrome. Patient UK website. Available at: http://www.patient.co.uk/doctor/stevens-johnson-syndrome. Updated November 2, 2012. Accessed October 3, 2013.

    Stevens-Johnson syndrome. Shriners Hospitals for Children website. Available at: http://www.shrinershospitalsforchildren.org/en/CareAndTreatment/Burns/Stevens-JohnsonSyndrome.aspx. Accessed October 3, 2013.

    Stevens-Johnson Syndrome/toxic epidermal necrolysis. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated November 17, 2011. Accessed October 3, 2013.

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