• Lobular Carcinoma in Situ

    (LCIS)

    Definition

    Lobules are a normal part of the breast which produces milk. Lobular carcinoma in situ (LCIS) occurs when abnormal cells grow in these lobules of the breast. These abnormal cells do not grow in an uncontrolled manner or spread to other areas of the body like cancer. However, LCIS is considered a risk factor for future breast cancer .

    Causes

    It is not clear exactly what causes LCIS. It is probably a combination of genetics and environment.

    Risk Factors

    LCIS is more common in premenopausal women, generally between 40-50 years old. Other factors that may increase your chance of LCIS include:
    • Family members with breast cancer
    • Increased exposure to estrogen
    • Use of hormone replacement therapy

    Symptoms

    LCIS does not have symptoms.

    Diagnosis

    LCIS does not appear on imaging tests, nor can it be felt during a manual breast exam. It is generally found by accident during biopsy of other nearby breast tissue.

    Treatment

    LCIS does not require treatment.
    Frequent follow-up visits and tests to monitor any changes in the breast tissue may be recommended because of the increased risk of breast cancer. If you detect any changes in either breast, call your doctor right away for an appointment.
    Other breast cancer prevention treatments may be recommended based on your overall risk of developing breast cancer. If you have a high risk of developing future breast cancer, your doctor may recommend:
    • Medications—To block estrogen receptors on breast tissue cells.
    • Surgery—A double mastectomy with reconstruction may be an option under special circumstances. It is generally considered to be an aggressive option.
    Talk to your doctor about the risks and benefits of having these treatments.

    Prevention

    There are no current guidelines to prevent LCIS because it is not known what causes it.

    RESOURCES

    American Cancer Society http://www.cancer.org

    National Cancer Institute http://www.cancer.gov

    CANADIAN RESOURCES

    Canadian Cancer Society http://www.cancer.ca

    Health Canada http://www.hc-sc.gc.ca

    References

    Lobular carcinoma in situ. American Cancer Society website. Available at: http://www.cancer.org/healthy/findcancerearly/womenshealth/non-cancerousbreastconditions/non-cancerous-breast-conditions-lobular-carcinoma-in-situ. Updated August 24, 2012. Accessed January 24, 2014.

    Lobular carcinoma in situ. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114068/Lobular-carcinoma-in-situ. Updated August 18, 2016. Accessed October 3, 2016.

    Lobular carcinoma in situ. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/breast/healthprofessional/page5. Updated November 19, 2013. Accessed January 24, 2014.

    Venkitaraman, R. Lobular neoplasia of the breast. Breast J. 2010;16(5):519-528.

    Revision Information

  • LiveWell personal health survey

    How healthy are you really? Find out – free.Learn more

    It's time to stop guessing. If you want to make some changes but just aren't sure how, the free personal health survey from LiveWell is a great place to start.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease and prevent heart attacks. HeartSHAPE® is a painless, non-invasive test that checks pictures of your heart for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.


  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.