8901 Health Library | Health and Wellness | Wellmont Health System
  • Finding Folate

    folate in fortified cereal The B vitamin folate, also called folic acid, is a water-soluble vitamin. Water-soluble vitamins are stored in the body in very limited amounts and are excreted through the urine. Therefore, it is a good idea to have them in your daily diet. Folate is considered a crucial vitamin before and during pregnancy. Research has shown that folate deficiencies during pregnancy can lead to neural tube birth defects in babies.

    Functions

    Folate's functions include:
    • Helping amino acid metabolism and conversion
    • Aiding in the conversion of homocysteine to methionine
    • Producing and maintaining new cells
    • Making DNA and RNA, the building blocks of cells
    • Preventing changes to DNA that may lead to cancer
    • Making red blood cells and preventing anemia
    • Assisting in the creation of neurotransmitters (chemicals that regulate sleep, pain, and mood)

    Recommended Intake:

    Age Group (in Years) Recommended Dietary Allowance
    Females Males
    1 - 3 150 mcg 150 mcg
    4 - 8 200 mcg 200 mcg
    9 - 13 300 mcg 300 mcg
    14 - 18 400 mcg 400 mcg
    Pregnancy, 14 - 18 600 mcg n/a
    Lactation, 14 - 18 500 mcg n/a
    19+ 400 mcg 400 mcg
    Pregnancy, 19+ 600 mcg n/a
    Lactation, 19+ 500 mcg n/a
    mcg=microgram

    Folate Deficiency

    Folate deficiency is a common vitamin deficiency. It can occur for a variety of reasons, including:
    • Need is increased, as with pregnancy
    • Dietary intake is lacking
    • Body is excreting more than usual
    • Medications interfering with the body's ability to use folate include:
      • Anti-convulsant medicines
      • Metformin
      • Sulfasalazine
      • Triamterene
      • Methotrexate
      • Barbituates
    Signs or symptoms of folate deficiency include:
    • Megaloblastic anemia (shown by blood tests)
    • Irritability, hostility
    • Weakness
    • Weight loss
    • Apathy, forgetfulness
    • Anorexia, loss of appetite
    • Sore tongue, glossitis (inflammation of tongue)
    • Headache
    • Heart palpitations
    • Paranoid behavior
    • Diarrhea

    Too Much Folate

    Large doses of folate can cause symptoms of vitamin B12 deficiency to appear. Vitamin B12 deficiency is common in older adults. Although folate supplementation will alleviate the anemia caused by the B12 deficiency, the nervous system damage caused by the B12 deficiency will continue. This is why it is important that you talk to your doctor before you take a folate supplement. It may be necessary for you to take vitamin B12 supplements along with the folate.
    There is no upper limit for ingesting folate found naturally in foods. However, there are tolerable upper intake levels for folate consumed from fortified foods and supplements:
    Age Micrograms (mcg) per day
    1-3 years 300 mcg
    4-8 years 400 mcg
    9-13 years 600 mcg
    14-18 years 800 mcg
    Pregnant or nursing women up to 18 years 800 mcg
    19 years and older 1,000 mcg
    Pregnant or nursing women 19 years and older 1,000 mcg

    Major Food Sources

    There is a variety of foods that contain folate. Some foods, like cereal, rice, and flour, are fortified with folate. Here is a list of major food sources and their folate content.
    Food Serving Size Folate Content
    (mcg)
    Chicken liver, simmered 3.5 ounces 770
    Fortified breakfast cereal 3/4 cup 100-400
    (check Nutrition Facts label)
    Soy flour 1 cup 260
    Beef liver, braised 3.5 ounces 217
    Chickpeas, canned 1 cup 160
    Pinto beans, canned 1 cup 144
    Spinach, boiled 1/2 cup 131
    Lima beans, canned 1 cup 121
    Papaya 1 medium 116
    Avocado 1 medium 113
    Wheat germ, toasted 1/4 cup 102
    Asparagus, boiled 4 spears 85
    Orange juice, fresh 8 fluid ounces 75
    Spinach, raw 1/2 cup 54
    Whole wheat flour 1 cup 53
    Green peas, boiled 1/2 cup 50
    White rice, long-grain 1/2 cup 45
    Orange, navel 1 medium 44
    Peanuts, dry roasted 1 oz 41
    Wheat flour 1 cup 40
    Broccoli, boiled 1/2 cup 39
    Tomatoes, sun-dried 1 cup 37
    Tomato juice, canned 6 oz 35
    Peanut butter, crunchy 2 tablespoons 29
    Cashews, dry roasted 1 ounce 20
    Banana 1 medium 20
    Bread, whole wheat 1 slice 15

    Health Implications

    Populations at Risk of Folate Deficiency

    The following populations may be at risk of folate deficiency and may require a supplement:
    • Pregnant women—Folate is critical for the production and maintenance of new cells. This is especially important during pregnancy—a period of rapid cell division.
    • People who consume excessive amounts of alcohol—Folate deficiency has been observed in alcoholics. Alcohol interferes with the absorption of folate and increases excretion by the kidneys. In addition, many alcoholics tend to have diets low in essential nutrients, like folate.
    • People on certain medicines—Certain medicines can interfere with the body's ability to use folate. Check with your doctor about supplementation if you are on medicine that may affect your folate levels.
    • People with inflammatory bowel diseases—Malabsorption of folate can occur with inflammatory bowel diseases.
    • The elderly—Many elderly have low blood levels of folate, which can occur from low intake of the vitamin or problems with absorption.

    Birth Defects

    In 1991, a landmark study found a relationship between folate and birth defects. Subsequent research has supported the finding that adequate folate intake during the period before and just after conception protects against a number of neural tube defects, including spina bifida and anencephaly.
    The crucial period is before and very early after conception—a time when most women do not know they are pregnant. Therefore, the recommendation is that all women of childbearing age make sure they have a folate intake of at least 400 mcg.

    Tips for Increasing Your Folate Intake:

    To help increase your intake of folate:
    • Spread a little avocado on your sandwich in place of mayonnaise.
    • Drink a glass of orange juice or tomato juice in the morning.
    • Add spinach to your scrambled eggs.
    • Slice a banana on top of your breakfast cereal.
    • Sprinkle some toasted wheat germ on top of pasta or a stir-fry.
    • Throw some chickpeas or kidney beans into a salad.
    • If you take a vitamin supplement, make sure it contains folate.

    RESOURCES

    Academy of Nutrition and Dietetics http://www.eatright.org/

    US Department of Agriculture http://www.usda.gov/

    CANADIAN RESOURCES

    Dietitians of Canada http://www.dietitians.ca/

    Health Canada http://www.hc-sc.gc.ca

    References

    Duyff RL. The American Dietetic Association's Complete Food & Nutrition Guide. 3rd ed. Hoboken, NJ: John Wiley and Sons, Inc.; 2006.

    Folate. Office of Dietary Supplements, National Institutes of Health website. Available at: http://ods.od.nih.gov/factsheets/Folate-HealthProfessional/. Accessed June 28, 2012.

    Folate deficiency. EBSCO DynaMed website. Available at: http://ebscohost.com/dynamed. Updated December 15, 2010. Accessed June 28, 2012.

    Folic acid. EBSCO DynaMed website. Available at: http://ebscohost.com/dynamed. Updated October 14, 2011. Accessed June 28, 2012.

    Garrison R, Somer E. The Nutrition Desk Reference. New Canaan, CT: Keats Publishing; 1995.

    Revision Information

  • Join WellZones today.

    Make a Change For LifeLearn more

    Wellmont LiveWell is creating a new tradition of wellness in the mountains by providing individuals with tools and encouragement to live healthier lifestyles.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease early and prevent heart attacks with HeartSHAPE® - a painless, non-invasive test that takes pictures of your heart to scan for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.


  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.