• Drug Resistant Cancers Have Alternative Drug Target

    Colorectal cancers resistant to anti-EGFR treatment often have MET amplification
    MONDAY, June 3 (HealthDay News) -- Cancers that develop resistance to anti-epidermal growth factor receptor (EGFR) treatments often have amplification of the MET gene, which can be targeted by drugs to overcome resistance, according to a study published online June 2 in Cancer Discovery.
    Alberto Bardelli, Ph.D., from the Institute for Cancer Research and Treatment in Torino, Italy, and colleagues sequenced the DNA from three patients with colorectal cancer who initially responded to panitumumab- or cetuximab-based treatment (anti-EGFR) and relapsed without displaying mutations in the KRAS gene, which are associated with resistance in about half of cases.
    The researchers found that the MET proto-oncogene was amplified, which could be detected in circulating tumor DNA before relapse. Xenografts of patient-derived colorectal cancer containing MET amplifications were resistant to anti-EGFR treatments, which could be overcome by treatment with MET kinase inhibitors.
    "These results highlight the role of MET in mediating primary and secondary resistance to anti-EGFR therapies in colorectal cancer and encourage the use of MET inhibitors in patients displaying resistance as a result of MET amplification," Bardelli and colleagues conclude.
    Several authors disclosed financial ties to pharmaceutical and diagnostic companies.
    Abstract (http://cancerdiscovery.aacrjournals.org/content/early/2013/05/16/2159-8290.CD-12-0558.abstract )Full Text (subscription or payment may be required) (http://cancerdiscovery.aacrjournals.org/content/early/2013/05/16/2159-8290.CD-12-0558.full.pdf+html )
  • LiveWell personal health survey

    How healthy are you really? Find out – free.Learn more

    It's time to stop guessing. If you want to make some changes but just aren't sure how, the free personal health survey from LiveWell is a great place to start.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease and prevent heart attacks. HeartSHAPE® is a painless, non-invasive test that checks pictures of your heart for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.

  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.