• Placental Growth Factor Useful for Predicting Preeclampsia

    Low PlGF has high sensitivity and negative predictive value for preeclampsia within 14 days
    TUESDAY, Nov. 5 (HealthDay News) -- Low plasma placental growth factor (PlGF) concentration has high sensitivity and negative predictive value for preeclampsia within 14 days, according to a study published in the Nov. 5 issue of Circulation.
    Lucy C. Chappell, Ph.D., from King's College London, and colleagues studied the diagnostic accuracy of low plasma PlGF concentration (<5th centile for gestation; Alere Triage assay) in 625 women presenting with suspected preeclampsia between 20 and 35 weeks' gestation (and up to 41 weeks' gestation as a secondary analysis). Delivery for confirmed preeclampsia within 14 days was the primary outcome.
    The researchers found that 55 percent of the women developed confirmed preeclampsia. For the 287 women enrolled prior to 35 weeks' gestation, PlGF <5th centile had high sensitivity (0.96) and negative predictive value (0.98), while specificity was 0.55 for preeclampsia within 14 days. For women presenting with suspected preeclampsia, low PlGF had an area under the receiver operating characteristic curve of 0.87 for predicting preeclampsia within 14 days, which was significantly greater than all other commonly used tests, either singly or in combination.
    "In women presenting before 35 weeks' gestation with suspected preeclampsia, low PlGF has high sensitivity and negative predictive value for preeclampsia within 14 days, is better than other currently used tests, and presents an innovative adjunct to management of such women," the authors conclude.
    Several authors disclosed financial ties to pharmaceutical and biotechnology companies, including Alere, which partially funded the study.
    Abstract (http://circ.ahajournals.org/content/128/19/2121.abstract )Full Text (http://circ.ahajournals.org/content/128/19/2121.full )
  • LiveWell personal health survey

    How healthy are you really? Find out – free.Learn more

    It's time to stop guessing. If you want to make some changes but just aren't sure how, the free personal health survey from LiveWell is a great place to start.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease and prevent heart attacks. HeartSHAPE® is a painless, non-invasive test that checks pictures of your heart for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.

  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.