• Chemotherapy for Breast Cancer

    Chemotherapy uses drugs to destroy breast cancer cells. The drugs enter the bloodstream and travel through the body to the cancer cells. Chemotherapy may be used:
    • Before surgery—to shrink the tumor and decrease the amount of tissue that needs to be removed
    • After surgery—to kill any remaining cancer cells and decrease risk of return
    • To help relieve symptoms of metastatic cancer and extend survival time
    Chemotherapy may also be used in conjunction with other therapies like radiation treatment, biologic therapy, targeted therapy, or hormone blocking therapy.

    Chemotherapy Drugs and Delivery

    There are a variety of chemotherapy drugs. The choice and combination of drugs will be based on your particular cancer and reaction to drugs. Chemotherapy drugs for breast cancer may include:
    • Cyclophosphamide, methotrexate, and 5-fluorouracil (CFM)
    • Cyclophosphamide, doxorubicin, and fluorouracil (CAF)
    • Doxorubicin and cyclophosphamide (AC)
    • Doxorubicin and cyclophosphamide followed by paclitaxel, docetaxel concurrent with AC, or docetaxel (TAC)
    • Doxorubicin, followed by CMF
    • Docetaxel and cyclophosphamide (TC)
    • Cyclophosphamide, epirubicin, and fluorouracil with or without docetaxel
    Chemotherapy is usually given by IV, but some forms can be given by mouth as well. IV chemotherapy is delivered in cycles over a set period of time. A medical oncologist will determine how many cycles of chemotherapy are needed and what combination of drugs will work best.

    Side Effects and Management

    Though the drugs are targeted to cancer cells, they can affect healthy cells as well. The death of cancer cells and impact on healthy cells can cause a range of side effects. A medical oncologist will work to find the best drug combination and dosage to have the most impact on the cancer cells and minimal side effects on healthy tissue. Side effects or complications from chemotherapy may include:
    • Nausea and vomiting
    • Fatigue
    • Hair loss
    • Memory and/or cognitive problems
    • Low blood cell counts (red cells, white cells, or platelets) that can lead to infection or bleeding
    • Premature menopause—including symptoms and loss of fertility
    Long term effects may include heart muscle damage (with doxorubincin) and rarely, leukemia.
    A variety of treatments are available to help manage side effects including medication, lifestyle changes, and alternative treatments. In some cases, the chemotherapy regimen may be adjusted to reduce severe side effects. The earlier the side effects are addressed, the more likely they will be controlled with a minimum of discomfort.


    Breast cancer. Merck Manual Professional Version website. Available at: http://www.merckmanuals.com/professional/gynecology-and-obstetrics/breast-disorders/breast-cancer. Updated May 2016. Accessed June 30, 2017.

    Breast cancer in women. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T113654/Breast-cancer-in-women. Updated May 31, 2017. Accessed June 30, 2017.

    Chemotherapy for breast cancer. American Cancer Society website. Available at: https://www.cancer.org/cancer/breast-cancer/treatment/chemotherapy-for-breast-cancer.html. Updated June 1, 2016. Accessed June 30, 2017.

    Chemotherapy for early and locally advanced breast cancer. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114271/Chemotherapy-for-early-and-locally-advanced-breast-cancer. Updated March 9, 2017. Accessed June 30, 2017.

    Chemotherapy for metastatic breast cancer. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T900469/Chemotherapy-for-metastatic-breast-cancer. Updated February 6, 2015. Accessed June 30, 2017.

    Treatment option overview. National Cancer Institute website. Available at: https://www.cancer.gov/types/breast/patient/breast-treatment-pdq#section/%5F185. Updated May 5, 2017. Accessed June 30, 2017.

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