• Neutropenic Fever

    (Febrile Neutropenia)


    A neutropenic fever is a temperature over 100.4°F (38°C) in a person with neutropenia. Neutropenia is a descriptive term referring to having a low number of neutrophils in the blood. A neutrophil is a type of white blood cell that helps to fight bacterial infections. As a result, when the neutrophil counts are low, the body is much more susceptible to infections.
    Medical care is important at the first sign of fever to best manage the cause of the fever and decrease the risk of serious complications.
    White Blood Cells
    nucleus fact sheet image
    Copyright © Nucleus Medical Media, Inc.


    The fever is usually caused by an infection.
    The body needs a specific range of neutrophils help to prevent and fight infections in the body. When the number of white blood cells in the body drops below normal levels, the body is less able to stop infections from developing or fight infections that have started. Early treatment of neutropenic fever is important to help the body fight the infection before complications develop. The reduction of neutrophils can have a number of causes, including viral infections or side effects to certain medications. It is most commonly associated with cancer or cancer treatments.

    Risk Factors

    Having neutropenia increases the chance of infection. The lower the neutrophil count and the longer it is present, the higher the risk. Other factors that may increase the chance of neutropenic fever include:
    • Increasing age
    • Uncontrolled cancer
    • Chronic obstructive pulmonary disease (COPD)
    • Liver or kidney problems


    • The hallmark symptom of neutropenic fever is a body temperature over 100.4°F (38°C). In some cases, it may be the only symptom.
      Other symptoms of fever include:
      • Chills
      • Sweating
    The infection may cause other symptoms depending on location and severity of infection. For example, a urinary tract infection may cause a burning sensation during urination, an infection in the lungs may cause a painful cough.


    You will be asked about your symptoms and medical history. A fever can be diagnosed by taking your temperature. If you have not been diagnosed with neutropenia, but your doctor suspects it based on your medical history, a blood test will be done for confirmation. Neutrophils are measured as part of a blood test called a CBC (complete blood count) that measures both red and white blood cell counts in the blood.
    One or more of the following tests will help identify the specific cause of the infection:
    • Blood tests and culture
    • Urine tests and culture
    • Cultures to test other suspicious tissue
    • Sputum samples
    • Stool samples
    • Lumbar puncture—evaluates the cerebrospinal fluid that protects the brain and spinal cord
    • Biopsy—tissue samples are examined under a microscope
    • X-rays of areas suspected as the infection source, such as the lungs or sinuses


    Treatment is started immediately. If the infection is not treated right away, life-threatening complications may occur.
    Neutropenic fever is most often treated with antibiotics that are known to fight a wide range of infections. Other medications may be used if another type of infection is suspected. For example, your doctor may suspect a fungal infection based on your history.
    Tests to identify specific infectious agents can take a few days to complete. Your medication may be changed based on the test results to best treat the infection.


    Some with neutropenia have a high risk for developing infection. Preventive antibiotics may be prescribed to help stop infections before they develop.
    Other steps include general infection precautions, such as:
    • Practicing good hand washing techniques.
    • Avoiding contact with people who are sick.
    • Keeping flu and pneumonia vaccines up to date.


    American Cancer Society http://www.cancer.org

    National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov


    Canadian Cancer Society http://www.cancer.ca

    Public Health Agency of Canada http://www.phac-aspc.gc.ca


    Book L. Neutropenic fever following chemotherapy in a patient with lymphoma. Oncol Nurs Forum. 2008;35(6):885-887.

    Febrile neutropenia. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated June 2, 2016. Accessed June 6, 2016.

    Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2011;52(4):427-431.

    Infections in people with cancer. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/002871-pdf.pdf. Accessed June 6, 2016.

    Revision Information

  • LiveWell personal health survey

    How healthy are you really? Find out – free.Learn more

    It's time to stop guessing. If you want to make some changes but just aren't sure how, the free personal health survey from LiveWell is a great place to start.

  • HeartSHAPE Spotlight

    At risk for a heart attack? Learn more

    Fight heart disease and prevent heart attacks. HeartSHAPE® is a painless, non-invasive test that checks pictures of your heart for early-stage coronary disease.

  • Calories and Energy Needs

    Calorie NeedsLearn more

    How many calories do you need to eat each day to maintain your weight and fuel your physical activity? Enter a few of your stats into this calculator to find out.

  • Ideal Body Weight

    Ideal Body WeightLearn more

    Using body mass index as a reference, this calculator determines your ideal body weight range. All you need to do is enter your height.

  • Body Mass Index

    Body Mass IndexLearn more

    This tool considers your height and weight to assess your weight status.

  • Can we help answer your questions?

    Wellmont Nurse Connection is your resource for valuable health information any time, 24 hours a day, seven days a week. Speak to a Nurse any time, day or night, at (423) 723-6877 or toll-free at 1-877-230-NURSE.